Your husbands case is definitely appearing hormone refractory if after two months he is still registering a detectable PSA. He needs to be on a 2nd line hormonal therapy and if his oncologist isn't on board with that then your husband needs to expand his medical team. I know of no reason that "plateauing" is a good thing when the PSA is so highHe can still do very well but this development indicates that this is not going well.
At this point I would also see is your husband can get DES, Keto, Nilandron, Abiraterone or Provenge as well but there may be better options right now.
My treasurer at my UsTOO group had the same thing happen last December. He tried DES, Nilandron and was placed on Provenge. His PSA is down to 2, but he may be headed to chemotherapy if the Provenge does not work. But as of now he looks good and is a wonderful man. He just completed his run on Provenge and it is still too early to tell what effect it has had on him. He is getting his next PSA after Christmas.
Don't panic but rather start questioning everything. There is still plenty of hope...
Advanced Prostate Cancer at age 44 (I am 48 now)
pT3b,N0,Mx (original PSA was 19.8) EPE, PM, SVI. Gleason 4+3=7
RALP ~ 2/17/2007 at the City of Hope near Los Angeles.
Adjuvant Radiation Therapy ~ IMRT Completed 8/07
Adjuvant Hormone Therapy ~ 28 months on Casodex and Lupron.
"I beat up this disease and took its lunch money! I am in remission."
I am currently not being treated, but I do have regular oncology visits.
I am the president of an UsTOO chapter in Las Vegas
Blog : www.caringbridge.org/visit/tonycrispino