Is there PC data that can be learned from the past?

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Jerry L.
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Date Joined Feb 2010
Total Posts : 3055
   Posted 12/8/2010 3:18 PM (GMT -6)   
I don't know if I am going to ask this that it makes sense, but here it goes:
 
With all these studies and trials that take future years to determine a conclusion, is anyone looking at the past as to what has worked and what hasn't worked with PC?
 
Why isn't there a central database available that contain specific information about PC patient's diagnosis, staging, treatment options, etc... It would not need to contain personal information.   You would think that over the past few decades there would be a lot of information to be learned from this data.  I know each case is different, but there has to be certain things that can be learned.
 
 

Steve n Dallas
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Date Joined Mar 2008
Total Posts : 4829
   Posted 12/8/2010 3:32 PM (GMT -6)   

I thought most studies were based on past procedures etc.

When you see numbers like there's a 92% chance it won't come back...that's based on history.


Jazzman1
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Date Joined Sep 2010
Total Posts : 1160
   Posted 12/8/2010 3:47 PM (GMT -6)   
Steve's got it right. A study showing that X percent of patients don't have a recurrence after 15 years has been following patients for 15 years. This is what the Partin tables, Han tables and various nomograms are based on.

The problem with those studies, of course, is that they're based on procedures that were done 15 years ago. While there's every reason to believe that outcomes will be better for patients being treated today, we don't really know how much better.

Check back in 15 years and we'll find out.

Tony Crispino
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Date Joined Dec 2006
Total Posts : 8128
   Posted 12/8/2010 6:20 PM (GMT -6)   
Hi Jerry,
That's another $ 64,000.00 question. I asked the same question when I arrived on the scene. While I have a little better picture as to why, the answer doesn't satisfy me. There is no central database other than the retrospective statistics that SEER keeps at the National Cancer Institute... A database that has only kept data since 1994, and has no requirements of doctors that mandates reporting. We have the 20+ years disease with 99% of studies ending at 10 years and they are mainly retrospective studies that are quite susceptible to bias search criteria, no database, and no one interested in starting one.

Tony
Disease:
Advanced Prostate Cancer at age 44 (I am 48 now)
pT3b,N0,Mx (original PSA was 19.8) EPE, PM, SVI. Gleason 4+3=7

Treatments:
RALP ~ 2/17/2007 at the City of Hope near Los Angeles.
Adjuvant Radiation Therapy ~ IMRT Completed 8/07
Adjuvant Hormone Therapy ~ 28 months on Casodex and Lupron.

Status:
"I beat up this disease and took its lunch money! I am in remission."
I am currently not being treated, but I do have regular oncology visits.
I am the president of an UsTOO chapter in Las Vegas

Blog : www.caringbridge.org/visit/tonycrispino

klains
Regular Member


Date Joined Nov 2010
Total Posts : 79
   Posted 12/8/2010 6:50 PM (GMT -6)   
This is not a study or a data base, but I found this particular site very informative with actually people writing in and updates . http://www.yananow.org/Chart-Ageu50.htm#40

proscapt
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Date Joined Aug 2010
Total Posts : 644
   Posted 12/8/2010 8:27 PM (GMT -6)   
Some of the nomograms (SKMCC's for example) have year of surgery as one of the inputs) reflecting the fact that outcomes have improved over time. For examples, a patient treated in 2009 has a better outcome than one treated in 2003. Whether that is due to improvements in technique, or to other factors such as escalation of Gleason scores, is open to debate. But it is comforting to think that innovations in treatment, greater surgical experience, and earlier diagnosis all play a part.

LV-TX
Veteran Member


Date Joined Jul 2008
Total Posts : 966
   Posted 12/9/2010 2:58 PM (GMT -6)   
The CapSURE database I think is attempting to do just that. I don't know what the current database size is, but it is a fairly large database of patients treated with the majority of the current treatment methods used today and then goes a little further with followup to side effects and recovery. The database was primary for urologists to use when planning the most effective methods for men diagnosed with prostate cancer and I could be wrong but is often used to create the nanograms that we see.
You are beating back cancer, so hold your head up with dignity

Les

Signature details in Sticky Post above - page 2

John T
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Date Joined Nov 2008
Total Posts : 4223
   Posted 12/9/2010 6:31 PM (GMT -6)   
Most of the past data is taken from speciality centers such as Hopkins and MSK as these are the centers that keep data. Few local hospitals and private practioners keep data or do followups. The data that we are looking at most likely reflects the best case senarios and not the most likely outcomes that a patient treated in a local setting would have.
JT
65 years old, rising psa for 10 years from 4 to 40; 12 biopsies and MRIS all negative. Oct 2009 DXed with G6 <5%. Color Doppler biopsy found 2.5 cm G4+3. Combidex clear. Seeds and IMRT, no side affects and psa .1 at 1.5 years.

klains
Regular Member


Date Joined Nov 2010
Total Posts : 79
   Posted 1/10/2011 2:18 PM (GMT -6)   
Just saw this site .. http://www.yananow.org/Chart-Ageu50.htm#40

zufus
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Date Joined Dec 2008
Total Posts : 3149
   Posted 1/10/2011 6:45 PM (GMT -6)   
Yananow can be useful, bolla studies seem to have held up well and are older than 10 yrs. old and other things that are worth going back to analyze.
Dx-2002 total urinary blockage, bPsa 46.6 12/12 biopsies all loaded 75-95% vol.; Gleasons scores 7,8,9's (2-sets), gland size 35, ct and bone scans look clear- ADT3 5 months prior to radiations neutron/photon 2-machines, cont'd. ADT3, quit after 2 yrs. switched to DES 1-mg, off 1+ yr., controlled well, resumed, used intermittently, resumed useage

klains
Regular Member


Date Joined Nov 2010
Total Posts : 79
   Posted 1/10/2011 7:13 PM (GMT -6)   
Is bolla studies a site ?

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 1/10/2011 9:13 PM (GMT -6)   
You can google Bolla studies his name appears as the lead doc amongest the group whom performed radiations studies for abstract that got published.

Post Edited (zufus) : 1/10/2011 8:23:39 PM (GMT-7)

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