Question for Tony/Moderator in particular

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25380
   Posted 12/8/2010 5:51 PM (GMT -6)   
Tony,
 
What do you know about a treatment called  Photodynamic Therapy?  Is it science or science fiction?  It's suppose to be some new method for dealing with prostate cancer patients who have failed both surgery as a primary treatment and salvage radiation as a secondary treatment.  It's not suppose to be either chemo or HT.  What's the deal?
 
David in SC
 
If anyone else knows jump in.

Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 12/8/2010 6:24 PM (GMT -6)   
David,
Apparently it's been around a while but there is little data on it. Terry Herbert has added it to his website in Australia and here is the link for it at his website...

www.yananow.net/choices.htm#PDT

I have no information on the efficacy of it and I would welcome any information to that effect...

Tony
Disease:
Advanced Prostate Cancer at age 44 (I am 48 now)
pT3b,N0,Mx (original PSA was 19.8) EPE, PM, SVI. Gleason 4+3=7

Treatments:
RALP ~ 2/17/2007 at the City of Hope near Los Angeles.
Adjuvant Radiation Therapy ~ IMRT Completed 8/07
Adjuvant Hormone Therapy ~ 28 months on Casodex and Lupron.

Status:
"I beat up this disease and took its lunch money! I am in remission."
I am currently not being treated, but I do have regular oncology visits.
I am the president of an UsTOO chapter in Las Vegas

Blog : www.caringbridge.org/visit/tonycrispino

Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25380
   Posted 12/8/2010 6:39 PM (GMT -6)   
Thanks for jumping in, Tony, I always figured with your involvement, you usually have heard of most if not all protocals and treatments, now and in the future. Any more info from anywhere would be helpful.

Thanks, too, questions.
Age: 58, 56 dx, PSA: 7/07 5.8, 10/08 16.3
3rd Biopsy: 9/08 7 of 7 Positive, 40-90%, Gleason 4+3
open RP: 11/08, on catheters for 101 days
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos marg
Incont & ED: None
Post Surgery PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, 8/6 .06 11/10 Not taking it
Latest: 6 Corr Surgeries to Bladder Neck, SP Catheter since 10/1/9, SRT 39 Sess/72 gy ended 11/09, 21 Catheters, Ileal Conduit Surgery 9/23/10

proscapt
Veteran Member


Date Joined Aug 2010
Total Posts : 644
   Posted 12/9/2010 10:25 AM (GMT -6)   
Hi, David

I checked on pubmed.com and tried a restrictive search requiring that both the words "photodynamic" and "prostate" appear in the article title. I got 74 hits. Many if not most appear to be about PDT as a focal therapy rather than a salvage therapy.

It might be worth scanning the rest of the hits. You can view abstracts for free. You might be able to get some of the full text articles from the online system of your local public library.

Paste this:

photodynamic[Title] AND prostate[Title]

in the search window at pubmed.

or try these variations to be even more restrictive:

photodynamic[Title] AND prostate[Title] and recurrent
photodynamic[Title] AND prostate[Title] and salvage


These look particularly relevant:

Vascular targeted photodynamic therapy with palladium-bacteriopheophorbide photosensitizer for recurrent prostate cancer following definitive radiation therapy: assessment of safety and treatment response.
www.ncbi.nlm.nih.gov/pubmed/17869307

Photodynamic therapy for prostate cancer--a review of current status and future promise.
www.ncbi.nlm.nih.gov/pubmed/19132003

Photodynamic therapy for prostate cancer recurrence after radiotherapy: a phase I study.
www.ncbi.nlm.nih.gov/pubmed/12352410

Vascular-targeted photodynamic therapy (padoporfin, WST09) for recurrent prostate cancer after failure of external beam radiotherapy: a study of escalating light doses.
www.ncbi.nlm.nih.gov/pubmed/18494829

There is also a wiki article on it en.wikipedia.org/wiki/Photodynamic_therapy that has some possibly useful references.

best,
David

edit: fix typos

Post Edited (proscapt) : 12/9/2010 9:50:11 AM (GMT-7)


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25380
   Posted 12/9/2010 3:46 PM (GMT -6)   
thanks for the tips, from david to david
Age: 58, 56 dx, PSA: 7/07 5.8, 10/08 16.3
3rd Biopsy: 9/08 7 of 7 Positive, 40-90%, Gleason 4+3
open RP: 11/08, on catheters for 101 days
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos marg
Incont & ED: None
Post Surgery PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, 8/6 .06 11/10 Not taking it
Latest: 6 Corr Surgeries to Bladder Neck, SP Catheter since 10/1/9, SRT 39 Sess/72 gy ended 11/09, 21 Catheters, Ileal Conduit Surgery 9/23/10

Sleepless09
Veteran Member


Date Joined Jul 2009
Total Posts : 1267
   Posted 12/9/2010 9:48 PM (GMT -6)   
David,

Might this be actually be ED therapy? At my age it wouldn't be much help, but when I was younger the photodynamics of Playboy centerfolds certainly had their attractions. Now when I see pictures like that my first thought is: she must be cold, posing like that. My second is: When she gets to my age, she's going to be sorry she didn't wear sunblock and a big hat all the time. My third thought is generally: I'd best put down the magazine. The ice cream in the fridge is calling for attention.

Sheldon AKA Sleepless
Age 67 in Apil '09 at news of 4 of 12 cores positive T2B and Gleason 3 + 3 and 5% to 25% PSA 1.5
Re-read of slides in June said Gleason 3 + 4 same four cores 5% to 15%
June 29 daVinci prostatectomy, Dr. Eric Estey, at Royal Alexandra Hospital Edmonton one night stay
From "knock out" to wake up in recovery less than two hours.  Actual surgery 70 minutes
Flew home to Winnipeg on July 3 after 5 nights in Ramada Inn  ---  perfect recovery spot!
Catheter out July 9
Final pathology is 3 + 4 Gleason 7, clear margins, clear nodes, T2C, sugeron says report is "excellent"
 
Oct 1st 09 -- dry at night, during day some stress issues.
Oct 31st padless 24/7 
 
First post op PSA Sept 09  less than 0.02
PSA on Oct 23, 2009 less than 0.02
PSA on Jan 8, 2010  less than 0.02
PSA on April 9, 2010 less than 0.02 
PSA on July 9, 2010 (one year) less than 0.02
  
New Topic Post Reply Printable Version
Forum Information
Currently it is Sunday, June 17, 2018 10:17 PM (GMT -6)
There are a total of 2,972,679 posts in 326,005 threads.
View Active Threads


Who's Online
This forum has 160834 registered members. Please welcome our newest member, Christina1984.
357 Guest(s), 2 Registered Member(s) are currently online.  Details
Magaboo, Tall Allen