Changing from Firmagon to Lupron tomorrow (Thursday)

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Veteran Member

Date Joined Nov 2010
Total Posts : 3619
   Posted 12/15/2010 2:07 PM (GMT -6)   
My husband has had two doses of Firmagon and tomorrow is changing to Lupron (so the injection will last three months).
I've read about a 'flare'? after Lupron.  What side effects can we expect?

Veteran Member

Date Joined May 2008
Total Posts : 1010
   Posted 12/15/2010 2:15 PM (GMT -6)   
Hello Joyce,
The flare can be prevented by taking Casodex for about two weeks prior to the first shot and one or two weeks following. If your husband has been on another hormone the flare may not be an issue. I would ask the doctor before the shot what he recommends.
Best to you and your husband.
Diagnosed 04/10/08 Age 58
Gleason 4 + 3
DRE palpable tumor on left side
100% of 12 cores positive for PCa range 35% to 85%
Bone scan and chest x ray clear
CT scan shows potential lymph node involvement in pelvic region
IGRT/IMRT with adjuvant HT (lupron) 2yrs
02/08 21.5
07/08 0.82
10/08 .642
09/09 0.32
03/10 0.32
06/10 0.32
07/10 0.10

Veteran Member

Date Joined Nov 2010
Total Posts : 3619
   Posted 12/15/2010 2:39 PM (GMT -6)   
Thanks Don, ...will do.

Regular Member

Date Joined Oct 2010
Total Posts : 54
   Posted 12/15/2010 4:06 PM (GMT -6)   
PA_grandma said...
My husband has had two doses of Firmagon and tomorrow is changing to Lupron (so the injection will last three months).

I've read about a 'flare'? after Lupron. What side effects can we expect?

Firmagon = degarelix. It blocks the production of GnRH (gonadotropin-releasing hormone) in the pituitary. This prevents stimulation of testosterone (T) by the GnRH.

Lupron directly prevents production of T.

The flare is the increase of T production upon first dosage of Lupron, Trelstar or Zoladex. This can be damaging, especially in cases where the patient is at an advanced stage. The usual means of avoiding flare is about a week of oral Casodex (bicalutimide) at 50 mg per day. Medics who prescribe the above three meds have a duty to be aware of this.
Dx 2004 at 67 yoa: Extensive Gleason 9 + Gleason 8.

Uro wanted to do cryotherapy, which I would have declined had I known anything. It failed, except I was rendered totally impotent; the only thing that worked as advertised.

IMRT + Lupron.

Studied PCa extensively.

Fired rad onc, who refused to read Dr. Strum's evaluation of my case.

Hired med onc. Have been on IADT since 2006.
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