Adovart helps in DXing PC

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John T
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Date Joined Nov 2008
Total Posts : 4235
   Posted 12/17/2010 12:46 PM (GMT -6)   

http://news.wustl.edu/news/Pages/21652.aspx

 

There has been a lot of discussions on using Adovart or Proscar. Some have indicated that it masks psa or that its use results in more agressive PC. This latest study indicates that it stablizes psa due to BPH and low grade cancer, and any futher psa increases are indicative of more agressive cancers. It could be very useful for those undiagnosed patients with low or slowly rising psa.

JohnT


Carlos
Regular Member


Date Joined Nov 2009
Total Posts : 486
   Posted 12/17/2010 3:51 PM (GMT -6)   
John T,  I wish that study had been published 4 years ago.  My PSA was remarkably stable and unchanged during the 10 year period that I used Proscar.  I stopped using it the year before my dx because it just wasn't helping the BPH.  My PSA accelerated very fast during the next year.  The Proscar may not have prevented the eventual progression but I certainly would not have stopped using it had I known of the possible benefit.  There had actually been some hints that proscar was beneficial but I made the mistake of waiting for "the study".   This is the frustating thing about getting old.  I just keep learning something new all the tilme.
 
Carlos

Dx 2/2008, age 71, PSA 9.1, G8,T1c. daVinci surgery 5/2008, G8(5+3), pT2c. LFPF, good QOL. PSA <0.1 for 2 yrs. PSA rose to .2 at 30 months, started SRT 12/15/2010.

Tony Crispino
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Date Joined Dec 2006
Total Posts : 8128
   Posted 12/17/2010 4:01 PM (GMT -6)   
This is not a good article. Vested interests all over the place.

Unfortunately this is more of an advertisement than a scientific representation of the facts. The article, study, and the doctor are all funded by the makers of Avodart (dutisteride is the active ingredient of Avodart):

"Editor’s note: Dr. Andriole is a consultant for GlaxoSmithKline, the manufacturer of Avodart® and the study’s sponsor."

Take out of this what you will, but this "study" has many flaws. And I admit to being turned off by Andriole's participation...


Tony
Disease:
Advanced Prostate Cancer at age 44 (I am 48 now)
pT3b,N0,Mx (original PSA was 19.8) EPE, PM, SVI. Gleason 4+3=7

Treatments:
RALP ~ 2/17/2007 at the City of Hope near Los Angeles.
Adjuvant Radiation Therapy ~ IMRT Completed 8/07
Adjuvant Hormone Therapy ~ 28 months on Casodex and Lupron.

Status:
"I beat up this disease and took its lunch money! I am in remission."
I am currently not being treated, but I do have regular oncology visits.
I am the president of an UsTOO chapter in Las Vegas

Blog : www.caringbridge.org/visit/tonycrispino

Post Edited (TC-LasVegas) : 12/17/2010 2:13:02 PM (GMT-7)


Carlos
Regular Member


Date Joined Nov 2009
Total Posts : 486
   Posted 12/17/2010 4:36 PM (GMT -6)   
Tony,  I know there is a conflict of interest and bias but isn't this the usual way we start learning and investigating new ideas.  The first study that suggested Proscar may have a benefit was sponsored by Merck.   These studies cost a lot of money so who else is going to do it?
 
Carlos

Tony Crispino
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Date Joined Dec 2006
Total Posts : 8128
   Posted 12/17/2010 5:25 PM (GMT -6)   
Carlos,
To some degree it is true that the manufacturers of these products need to fund studies to promote the safety and efficacy of their drugs. And these manufacturers should bear these costs to substantiate their claims. As I said take out of this what you will, but also note that this article does neither verify or state the efficacy as a drug that will help detect tumors that are either indolent or aggressive prostate cancer. I am critical of all studies in prostate cancer as for one thing I have seen many design their "studies" in particular for increasing the sales of products or services. This is a great example. If you have an enlarged prostate, Avodart is approved for that treatment. So is Flowmax, Proscar, and a few others.

Then there's another side of this. It's almost like GSK is suggesting that men should start taking Avodart just for this purpose ~ and that's absolutely absurd. You should take it if you have an enlarged prostate and your doctor approved it.

Ironically, there is a study out there that suggests that finasteride (Proscar) helps men at high risk for prostate cancer delay the onset of prostate cancer. But that same study also showed that the non-placebo arm of the study had a higher incidence of more aggressive tumors. So now the question isn't does it prevent the onset, but rather just suppress the ability to detect prostate cancer? The spin on this article seems to say the same thing in a different way.

Tony

Post Edited (TC-LasVegas) : 12/17/2010 4:41:59 PM (GMT-7)


JNF
Veteran Member


Date Joined Dec 2010
Total Posts : 3794
   Posted 12/20/2010 3:48 PM (GMT -6)   
I am on Jalyn, which is Avodart and Flomax, and Eligard. My urologist has me on Jalyn to supress the DHT while the Eligard supresses the testosterone. He explained that we have to be very consistent with the use of Avodart as it will reduce PSA. Spotty or intermittant use may give missleading results. Snuffy Meyers makes use of Proscar for the same effect as Avodart to supress the DHT.

As for pharma publishing studies...that is all part of the system and we have to be discerning enough to understand them and to look at other studies as well. The more studies and information the better we off we become.......just more difficult to cut through the clutter and agendas.
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