I had regular PSAs and DREs beginning at age 40. For purposes of full disclosure I do not have a family history of prostate cancer nor am I of African descent. The PSAs were all low until the spike that initiated the biopsies, that diagnosed the PCa, that started the treatment. I have never had any urological problems prior to the PCa.
PSA quadrupled in one year (0.6 to 2.6)
DRE negative 1 of 12 biopsies positive (< 5%)
open RRP surgery June 2006 at age 57
Organ-confined to small area Gleason 5
Bilateral nerve-sparing prostate weight 34 grams
PSAs < 0.1