Latest Paact Newsletter~synopsis of information~newer drugs/Moyad, etc.

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zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 12/30/2010 8:16 AM (GMT -6)   
Well for those whom are not yet subscribers to  www.paactusa.org  , newsletter  (Patient Advocates for Advanced Cancer Treatments=Paact).  It has some great stuff in it and mostly from MD/MPH Mark Moyad, some from Dr. Myers, Dr. Turner,  and Lewis Pfeffer.
 
Abiraterone Acetate- Phase 3 trials in the USA currently,  Trial results from 147 medical centers in 13 countries (meeting info from Milan, Italy) had this as to some results in patients:
35% reduction in risk of dying and 36% increase in median survival vs. placebo, 38% men on this had 50% or greater reduction ins PSA compared to 10% in placebo group. Claimed this 10-30 times more potent than Ketoconazole which has been with us for years. Mark mentioned:
'"tumors make their own testostorone despite men having castrate levels of 'T' from LHRH drugs and now there is a drug to keep certain tumors from feeding itself so to speak." The good news is Dr. Scholz and Dr. Lam are getting this drug to their patients right now through allowed useage from Johnson & Johnson   (FDA approval sees very likely on this)
 
Dasantinib  (Sprycel)- approved for leukemia, and currently testing in Phase 3 for mHRPCa
(m=metastatic)  Made by Bristol-Myers Squibb. Being tested with Taxotere at 100 mg per day, study to be completed by 2012  (leukemia type known as CML has access to this drug now).
  
Forteo (teriparatide)-  osteoporois drug (may have issues, tested at U of Mich.)
 
Ipilimumab (aka=  MDX-010 or MDX-CTLA4)  is an iv immune enhancing drug in phase 3 for men that no longer respond to Taxotere. Has shown some success in Melanoma patients already may get approved for them in early 2011.  Possible issue- overactive immune response might cause side effects.
 
Jevtana  (Carbazitaxel) FDA approved, used with Prednisone and in mHRPCa patients previously treated with Taxotere, this drug has worked well in some very ill patients. The question is whether to use Jevtana prior to Taxotere, says Mark.
 
MDV3100  tested in mHPRCa patients in phase 3 trials. Requires no steriod, and not only blocks the androgen receptor, but does not allow the receptor to move into the cell to interact with DNA so that the growth signal to the cancer is blocker. Fatigue observed in high doses. Has been name Super Casodex in the past (fyi).
 
Denosumab (Prolia)-  a subcataneous injection done one 4very 6 mothis on average. currently in clinical trial, may be available within months. Approved for women ins the USA with post-menopausal osteoporosis to prevent bone fractures, approved in Europe for men with mHRPCa.  Comparable to Zometa to prevent SRE's  (skeletal related events).
 
Provenge-  Being used right now on some patients, unknown if approval from Medicare is coming anytime soon.
 
Revlimid  (Lenalidomide)  Used already on multiple myeloma patients, drug is known for having multiple effects such as blocking blood vessel tumor growth, immune enhancement and acting as an anti-inflammatory compound. There is a chance that men with PCa could get this drug 'off-label'. Drug is similar to thalidomide which is potent stuff, note it is expensive in pill form.
 
Unsung-  iv injectable drug in phase 3 trials for HRPCa   (need more info to as to results)
 
Other drugs that need attention as to maybe being useful for us PCa patients:
Aflibercept; OGX-011 (Custirsen sodium); Prostvac-vf  (poxviral vaccine); Radium-223 (Alpharadin)
 
Also an article from Dr. J. Turner on debunking the myth on replacement 'T' adding fuel to the fire for men with PCa.   (read and decide for yourselves as to its revelations)
 
Dr. Myers article on  'Foods to Avoid'-  bascially good information, alot of it we know as righteous eating like Mediterranean or reflecting on diets like the Okinawans. Mention of supplements to avoid like flaxseed oil, chondroitin sulfate, beta carotene in multi-vatimins(pills) better to get from food sources, copper used in multi-vitamins trial results suggested it helped the cancer, thus harmful. Info on diets, supplements to avoid and treatments from his video blog  http://askdrmyers.wordpress.com/
 
Lewis Pfeffer (Chairman of PCa forum of Orange Co.)- synopsis of drug prices and large variances in pricings. Example of generic Casodex (bicalutamide)  90 tablets:
CVS=$449.99;  Sone-On= $450' Von's= $450; target= $1,124.99; Albertsons's= $1,337.07; Rite Aid= $1,439.99   Has many other examples of pricing, too. He mentions the website www.themedia.com showing generic drug manufacturers and many are from China or India. The USA suppliers of generic casodex are  Tecoland Corp.(N.J.) TEVA Pharm. (P.A.) Teva's drugs also made in Jerusalem.  If you are worried about generics info within www.consumerreports.org (March 2009) in general was positive about generics, some issues with FDA actual inspections and that duration and percentage of foreign inspections for USA sales items.
 
Paact partners with discount Rx services (includes all of us looking):
No fees to join, the average customer saves supposedly $400 to $4000 per year.
www.discountprescriptionservices.com/?agentcode=68741   (promo ID# 68471)  You decide if its worth it to you to contact them. With an Rx you can shop Canada drugs and have them shipped, usually 50% less than in the USA on averages.
 
They ask for donations for their Newsletter as they are not funded by any drug companies and such, it is independently run and this group was founded in 1984.  Dr. Strum was originally envolved with helping to treat the founder Lloyd Ney, through his joined work with Dr. Labrie (Canada), Lloyd as amongest the first in the USA getting bicalutamide and getting it approved into the USA, back then. wink
 

Post Edited (zufus) : 12/30/2010 6:21:38 AM (GMT-7)


Jerry L.
Veteran Member


Date Joined Feb 2010
Total Posts : 3072
   Posted 12/30/2010 1:48 PM (GMT -6)   
Thanks Zufus...Good information.
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