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AJ74666
New Member


Date Joined Aug 2010
Total Posts : 12
   Posted 1/11/2011 7:13 PM (GMT -6)   

I hope you dont mind me posting a ED question in the Prostate Cancer section.

 

I am a 49 year old parkinson's sufferer, but otherwise in excellent health, with ED.  

 

My equipment no longer responds to Viagra, Levitra or Cialis.  I have occasionally excellent results with Tri-mix. But it either works unbelievably well or doesn’t work at all (50% success)

 

I either get an erection that would make an 18 yr jealous or I get zero results.  The dosage and injection site are unchanged.  My initial quantity is .70cc.  And sometimes (again 50%) the initial injection is unsuccessful yet a second one is. 

 

Question how can I improve the success ratio? Any suggestions? Thank you!


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4463
   Posted 1/11/2011 7:18 PM (GMT -6)   
Welcome to HW.

I, and several other guys, use what I call a pre-plump method to ensure successful injections. It begins with a penis pump, if you have one, and a penis ring. Using the pump, obtain a partial- maybe 30%- erection and apply the ring. This engorges the penis with blood, opening the cavernous cavities and filling them with blood. Then inject into this expanded cavity. Imagine injecting into an uninflated balloon, and putting the drug into the inside, versus injecting into a partially inflated one. That's what is being accomplished with this method. When injecting, you can easily tell when the needle point enters the cavity, as the resistance will drop and the needle will feel like it has 'fallen' into it. Inject and very lightly massage the penis, the purpose is to spread the drug around and ensure optimium adsorption of the drug. Keeping the ring on for 3 or 4 minutes holds the blood (and drug) inside and lets it have the best chance of being adsorbed. Continue to gently massage the penis and the drug around for 3 to 4 minutes, then remove the ring- the blood will most likely run back out of the penis, until the erection begins. You should get the drug induced erection in 5 minutes or so. Most of us who use this method find we can use much less drug, we can control results more consistently from one time to the next and reduce the chance of priaprisms.
James C. Age 63
Gonna Make Myself A Better Man tinyurl.com/28e8qcg
4/07: PSA 7.6, 7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS6
9/07: Nerve Sparing open RP, Path: pT2c, 110 gms., clear except:
Probable microscopic involvement-left apical margin -GS6
3 Years: PSA's .04 each test until 04/10-.06, 09/10-.09, 01/11-.09
ED-total-Bimix 30cc

MrGimpy
Veteran Member


Date Joined Jul 2009
Total Posts : 504
   Posted 1/11/2011 8:39 PM (GMT -6)   
Hi AJ74666,

The great news is that you took the leap and went to Trimix. The even better news is that your 50% success rate can get to 100% easily with some fine tuning of your injection procedure. There are many posts on how to plump-prick-constrict to a 100% rate using the same dosage

Piano
Veteran Member


Date Joined Apr 2008
Total Posts : 847
   Posted 1/11/2011 11:33 PM (GMT -6)   
I used the method that James described, except no pumping, just constriction. I found that three minutes of constriction after injection was enough.
No symptoms; PSA 5.7; Gleason 4+5=9; cancer in 4/12 cores
Non-nerve-sparing RRP 7 March 2008 age 63
Organ confined, neg margins. Gleason downgrade 4+4=8
Fully continent
Bimix worked well; now using just VED
PSA undetectable at first but now 0.3, doubling time 7 months
No radiation but ADT coming unless I can slow down the rise...

Steve n Dallas
Veteran Member


Date Joined Mar 2008
Total Posts : 4849
   Posted 1/12/2011 5:42 AM (GMT -6)   
Are you doing the injections on an empty stomach?

AJ74666
New Member


Date Joined Aug 2010
Total Posts : 12
   Posted 1/12/2011 9:23 AM (GMT -6)   
thanks for great advice! I will order a pump and ring today...

would a longer needle 1/2" vs. 5/16" help.

as to the question of empty stomach, I have never tracked or correlated empty stomach with erection success.

are you suggesting that an empty stomach helps with something injected straight into penis?

Thanks for the excellent replies!

Cajun Jeff
Veteran Member


Date Joined Mar 2009
Total Posts : 4119
   Posted 1/12/2011 9:45 AM (GMT -6)   
Must say some times we miss too. I recommend that you visit Franktalk.org. All you ever wanted to know about ED and more. Their chat room is very active and the guys will help you out.

Cajun JefF

James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4463
   Posted 1/12/2011 6:36 PM (GMT -6)   
Usually, we mention empty stomach with the use of Viagra, which requires an empty stomach to be most effective. I suspect Steve may be a little confused... smilewinkgrin If the 5/16 works now, it will work fine with the plumping. Try the 5/16 first.
James C. Age 63
Gonna Make Myself A Better Man tinyurl.com/28e8qcg
4/07: PSA 7.6, 7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS6
9/07: Nerve Sparing open RP, Path: pT2c, 110 gms., clear except:
Probable microscopic involvement-left apical margin -GS6
3 Years: PSA's .04 each test until 04/10-.06, 09/10-.09, 01/11-.09
ED-total-Bimix 30cc

AJ74666
New Member


Date Joined Aug 2010
Total Posts : 12
   Posted 1/14/2011 3:07 PM (GMT -6)   
Guys,

Thanks for great suggestions! I have excellent news to report:

first night: using longer needle 1/2" and pump resulted in a four hour erection using .7 cc. Had to use sudafed to bring it down.

second night: lowered tri-mix dose to .5 cc, still highly effective, required sudafed again.


Needless to say, I am very happy with new found success, now all I have to is titrate down until i find the optimal dosage... perhaps .3 cc?

Tri-mix at $70 for 10ML is vastly more cost effective than viagra or cialis or levitra, and for me, efficacy is even more so.

Thanks again!

James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4463
   Posted 1/14/2011 3:23 PM (GMT -6)   
Sure, try the .3, it'll help you dial it in faster. Glad you found success with this method. Let us know your progress and what you end up using, as far as dose goes.
James C. Age 63
Gonna Make Myself A Better Man tinyurl.com/28e8qcg
4/07: PSA 7.6, 7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS6
9/07: Nerve Sparing open RP, Path: pT2c, 110 gms., clear except:
Probable microscopic involvement-left apical margin -GS6
3 Years: PSA's .04 each test until 04/10-.06, 09/10-.09, 01/11-.09
ED-total-Bimix 30cc

Steve n Dallas
Veteran Member


Date Joined Mar 2008
Total Posts : 4849
   Posted 1/14/2011 3:25 PM (GMT -6)   
AJ74666
 
I was told that Trimix should not be used more than three times a week or more than once every 24 hours....
 
But then again, I was also told that injecting on an empty stomach was better then right after dinner...

AJ74666
New Member


Date Joined Aug 2010
Total Posts : 12
   Posted 1/14/2011 3:34 PM (GMT -6)   
What is the risk associated with more than 3x per week or 2x per 24 hours?

Steve n Dallas
Veteran Member


Date Joined Mar 2008
Total Posts : 4849
   Posted 1/14/2011 4:00 PM (GMT -6)   

Considering where you're injecting - letting your imagination run wild should be enough to consider being cautious.

But you can Google-> Timix Side Effects

 


AJ74666
New Member


Date Joined Aug 2010
Total Posts : 12
   Posted 1/17/2011 9:12 AM (GMT -6)   
OK guys, thanks again for all of the helpful responses!

it looks like .03 is the magic number, but now I cant seem to ejaculate/orgasm, any suggestions here?

Thanks so much for your help and patience.

PS this board (for the most part) has been far more helpful and seemingly informed than my uro.

MrGimpy
Veteran Member


Date Joined Jul 2009
Total Posts : 504
   Posted 1/17/2011 9:30 AM (GMT -6)   
Hi AJ74666

When you asked "What is the risk associated with more than 3x per week or 2x per 24 hours?"

1) The obvious,, risk of infection
2) Risk of your partner now expecting that rock hard 1.5 hr erection for the rest of her live with you 4 x a week or more that 2x in a 24 hr period ( give her a rest man)

pace yourself. do not built expectations you will have to back off from. At some point you will be taken off Trimix what will you do then with "Only" a 20 minute erection ?


Also note: once a person has their prostate removed there is no longer an ejaculation. So its always neat and tidy now

James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4463
   Posted 1/17/2011 10:06 AM (GMT -6)   
When you say you can't now, when last could you easily? Is this related to your starting to use Trimix?
James C. Age 63
Gonna Make Myself A Better Man tinyurl.com/28e8qcg
4/07: PSA 7.6, 7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS6
9/07: Nerve Sparing open RP, Path: pT2c, 110 gms., clear except:
Probable microscopic involvement-left apical margin -GS6
3 Years: PSA's .04 each test until 04/10-.06, 09/10-.09, 01/11-.09
ED-total-Bimix 30cc

AJ74666
New Member


Date Joined Aug 2010
Total Posts : 12
   Posted 1/17/2011 11:56 AM (GMT -6)   
starting after trimix became "effective" in generating erections (longer needle, use after semi-hard, etc.)

thank you, if you can help or having experienced something similar, I would appreciate your comments...

James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4463
   Posted 1/17/2011 2:24 PM (GMT -6)   
Well, honestly, I can't see how a dependably hard erection can be any cause of failure to climax, as opposed to a hit or miss, works or not approach using the same drug. When it worked before using trimix, did you have the same difficulty? You said in your first post:

I have occasionally excellent results with Tri-mix. But it either works unbelievably well or doesn’t work at all (50% success) In this case did you have difficulties then? How long has it been that you have had to depend on the drugs to make you erect? Any previous, before that time, experiences with failure to climax?
James C. Age 63
Gonna Make Myself A Better Man tinyurl.com/28e8qcg
4/07: PSA 7.6, 7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS6
9/07: Nerve Sparing open RP, Path: pT2c, 110 gms., clear except:
Probable microscopic involvement-left apical margin -GS6
3 Years: PSA's .04 each test until 04/10-.06, 09/10-.09, 01/11-.09
ED-total-Bimix 30cc

AJ74666
New Member


Date Joined Aug 2010
Total Posts : 12
   Posted 1/17/2011 2:38 PM (GMT -6)   
We had a little difficulty (occasionally) before, but if we "worked" at it, it would eventually "work". It has only happened three times, perhaps our sample size is too small?

We will continue to work and report back.

So my experience (decreased ability to orgasm) is not a common (or uncommon) side effect of tri-mix?

Thank you again for your reply you have most helpful!!!!

James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4463
   Posted 1/17/2011 3:00 PM (GMT -6)   
Ok, here's my take on it, just my opinion. First, this problem is more common as we age. (General statement #1) I think if we polled it, we would find a significant number who has difficulty gaining a climax as they get older. Some easy things to blame would be boredom (sorry, girls) , worry that we might not be able to perform, resulting in a self-fulfilling prophecy, loss of sensitivity after major treatments (remember, I'm speaking of possible experience of prostate cancer guys, who can have very large and serious ED issues with any of the various treatment options, probably much the same with some options for drug side effects from Parkingson's treatments. That's just general possibilities, and not all of them.

Now, it has been my experience with trimix that it does have a slight numbing effect when I use it, I think in my case, it's the alprostadil in it, which is known to cause aching and or pain, so I always get a slight amount of the aching which can be distracting when having sex. This, I suspect may be your problem. You haven't had a lot of successful episodes yet, so this may not amount to much evidence as you continue to use it. I would suggest that you continue decreasing the amount of trimix to the point that you can have a repeatable erection lasting around an hour. Maybe with less use, the problem will solve itself.

There is another alternative, if you wish to try it, and if you think the trimix is causing a problem big enough to go with something else. As you probably know, the bimix is the same thing without the alprostadil. If it worked to give you the erection, you might find that it doesn't affect you the same way. You use more but have less side effects.

I hope this has given you some ideas to followup. Good luck, report back with results... tongue
James C. Age 63
Gonna Make Myself A Better Man tinyurl.com/28e8qcg
4/07: PSA 7.6, 7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS6
9/07: Nerve Sparing open RP, Path: pT2c, 110 gms., clear except:
Probable microscopic involvement-left apical margin -GS6
3 Years: PSA's .04 each test until 04/10-.06, 09/10-.09, 01/11-.09
ED-total-Bimix 30cc
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