Tidbits stuff from PCa meeting I went to, HT hot flushes options & Bone density info Dr. Yu video

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zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 1/12/2011 8:31 AM (GMT -6)   
First off about HT androgen deprivation therapy and getting hot flushes, sweats, hot flashes:
 
Things that might work for a patient:
Megace
Megestrol
Cyproterone acetate
soy products ( ???) still some questions on proof
Gabapentrin
Zoloft  and  Effexor (anti-depressants can work):  Dr.  Yu is using  3.75 mg. (Effexor) of this in some patients and has found they got results  (go figure).
 
Provigil can help to fight fatigue with using HT  redface -----------------------------------------------------------------------------------
 
Bone density info:
Fosamax  (we know about)
Zometa or zolendronic acid I.V., there study had 5% density improvement shown within 12  months.
Alendronate  showed a 5% denisty increase also
Toremifene  80 mg. increased BMD, bone density but is non-FDA approved currently
Denosumab  showed a 6.7% increase at 24 mos. (subcataneous useage) non-FDA still
  also it showed 62% reduction in vertrebrate fractures over 36 mos. time
 
Other onco-docs he worked with on such studies,  C. Higano and R. Montgomery
(Dr. Yu is at Washington Univ. Hospital)  looks much younger than he actually is!  tongue

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 1/16/2011 10:42 AM (GMT -6)   
Bump and pumped for newer readers to know, just in case it helps someone. These newer bone density drugs are going to be important and some will likely get approved or available.
Someone in my prostate group mentioned that he knows of some people getting things that are non-fda approved (just yet)...but found possible way(s) to get them, might include politics or wrangling, a name was dropped but decided I better not mention it here, some of us would know the name. He has gotten some patients a drug that was non-fda approved and from the manufacturer, maybe not real often but has happen.....heard it throught the grape vine...believe it to be the case. Just like Dr. Scholz and Lam have a deal with Johnson & Johnson to use Abiraterone, which in non-fda approved just yet. Patients are getting it right now and this was mentioned in Paact Newsletter.
 
 

Post Edited (zufus) : 1/16/2011 9:45:06 AM (GMT-7)


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25380
   Posted 1/16/2011 10:52 AM (GMT -6)   
zufus - the things mentioned by your for hot flashes, can I assume they would probably work for women in menopause with hot flashes? Or is that a different animal?

David
Age: 58, 56 dx, PSA: 7/07 5.8, 10/08 16.3
3rd Biopsy: 9/08 7 of 7 Positive, 40-90%, Gleason 4+3
open RP: 11/08, on catheters for 101 days
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos marg
Incont & ED: None
Post Surgery PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, 8/6 .06 11/10 Not taking it
Latest: 6 Corr Surgeries to Bladder Neck, SP Catheter since 10/1/9, SRT 39 Sess/72 gy ended 11/09, 21 Catheters, Ileal Conduit Surgery 9/23/10

Mitch128
Regular Member


Date Joined Aug 2010
Total Posts : 83
   Posted 1/16/2011 6:24 PM (GMT -6)   
<can I assume they would probably work for women in menopause with hot flashes?>
 
Yes.
 
<Or is that a different animal?>
 
No.
 
What worked for me was time - about 6 months.
 
Mitch in SC
 


 

F8
Veteran Member


Date Joined Feb 2010
Total Posts : 3800
   Posted 1/16/2011 6:37 PM (GMT -6)   
celexa worked for me.  i didn't have hot flashes until the expiration of my last shot of lupron, and i would say they are moderate in strength.

ed
age: 55
PSA on 12/09: 6.8
no symptoms, no prostate enlargement
12/12 cores positive....gleason 3+4 = 7
HT, BT and IGRT
received 3rd and last lupron shot 9/14/10
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