Hi, Mack. Good luck with your upcoming surgery and travel. In December, a friend of mine drove 9 hours to Mayo in Minnesota, then 9 hours back home, and a week later made the trip again to have the catheter removed. He did fine, so I would say your trip is do-able.
The idea of travel didn't appeal to me, but from what I've seen here, if you're in reasonably good physical shape, and especially if you're on the younger side, you should do fine.
It would be interesting to hear, though, what led you to choose a trip to Boston instead of having your open surgery done in or near Atlanta. If you'd be willing to share your decision-making process, I think it would make interesting reading. In any case, please keep in touch and don't hestitate to share any questions you may have.