My only problem to date has been hot flashes, I've been on lupron for over 18 months. I'm ready to get off( 4 to 5 more months) but will do it again if I have to. I believe the main thing about lupron is to continue to exercise as much as possible. Just my thoughts, there are a group of us who have been there, done that with experiences. I wouldn't listen too much to anyone who hasn't actually experienced the effects. We all react a little differently.