The answer to this is yes, it can be inherited down the maternal line. It is briefly described in Dr Strum's "A primer on prostate cancer". I used the references in the back of Dr Strum's book to investigate further. There is a difference between Familial Prostate cancer (which is far more common) and Heriditary Prostate cancer (which is tightly defined, and from what I could see, the outcomes were much more clearly defined).
Heriditary prostate cancer is thought to be carried down generations by a set of yet to be identified genes. It can be carried down the maternal line. The definition of heriditary prostate cancer is when three generations of a family come down with prostate cancer. From memory a person with these set of genes have something like a 43% chance of handing down their genes to each of their children. If the child is a girl and she gets these sets of genes then she in turn has a 43% chance of handing down the genes to each of her children. If you have the genes and if you are a man then you have something like 87% chance of getting PCa. And the likelihood is that your cancer will be diagnosed at a much younger age (thus making it much more deadly) - if I remember correctly, people with the hereditary version of the disease got diagnosed on average 12 years below the overall average age of diagnosis for PCA. (I would get the exact numbers for except I am not writing this from home where all my research is, I am pretty sure it's close though).
My husband, Paul, has hereditary PCa from the maternal line. His maternal grandfather died of the disease at age 72. Paul's grandfather had 6 children. 2 male children, Paul's maternal uncles, got diagnosed with the disease, one dying at 60 of PCa. Paul's mother most likely inherited the gene which she gave to Paul and Paul got diagnosed at the age of 52. He has informed all of his maternal cousins of what we have learnt so that they are diligent about doing PSA tests. Nothing I read indicated that in case of hereditary PCa suggested that girls with these genes would be affected at all and in the case of Paul's mother, in is in fantastic health at 89, this seems to be bourne out. This may be different for Familial PCa.
Hope this helps,
Husband's age: 52. Sydney Australia.
Family history: Mat. grandfather died of PC at 72. Mat. uncle died of PC at 60. He has hereditary PC.
PSA: Aug07 - 2.5|Feb08 - 1.7|Oct09 - 3.67 (free PSA 27%)|Feb10 - 4.03 (free PSA 31%) |Jun10 - 2.69. DRE normal.
Biopsy 28Apr10: negative for a diagnosis of PC however 3 focal ASAPs “atypical, suspicious but not diagnostic” for PC. Review of biopsy by experienced pathologist, 1/12 core: 10% 3+3 (left transitional), 1/12 core: ASAP (left apex)
Nerve sparing RP, 20Aug10 with Dr Stricker. Post-op path: 3+4 (ISUP 2005). Neg (margins, seminal vesicles, extraprostatic extension). Multifocal, with main involvement in the fibro-muscular zone. T2C.
Post RP PSA,
Lab 1: Sep10 – 0.02|Nov10 – 0.03|Dec10 – 0.03
Lab 2: Nov 10 - 0.01|Dec10 – 0.01
Post Edited (An38) : 1/24/2011 11:53:43 AM (GMT-7)