Genetic Testing??

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Regular Member

Date Joined Jun 2008
Total Posts : 91
   Posted 1/29/2011 1:14 PM (GMT -6)   
Up until yesterday, I completely believed genetics had NOTHING to do with my "early" prostate cancer since I knew of no family history of this disease. However, my Mother forwarded a letter to me recently sent to her by "my Dad's cousin," claiming she had tested positive for a BRCA 1 gene mutation that apparently is linked to both breast and prostate cancers. Her letter also stated several of my "distant relatives" had breast and prostate cancers. I have not yet followed-up with her to see exactly who she is referring to.

Anyway, I'm curious if anyone on this board knows anything about the BRCA link with prostate cancer, and if I should be screened for this genetic mutation. If it turns out that I have the genetic condition, at least it provides a theory on "why me." It then also might be important to see if my son and daughter have the genetic condition so they can be closely monitored as they get older.

Any thoughts? Thanks...
Diagnosed at 47 (currently 50). Pre-surgery PSA: 13.7 Pre-surgery Gleason: 4+3=7. CT Scan, Bone Scan, PET Scan: Clear. LRP May 28, 2008. Left nerve bundle removed. POST-SURGERY: Gleason: 4+3=7;10% of prostate all quadrants involved; EPE left base & apex; extensive PNI present. Bladder neck, lymphvasular space, seminal vesicles, 17 examined lymph nodes, and all surgical margins FREE of tumor. T3a. Four-week post-surgical PSA = 0.1; Seven-week = .01; October 2008 – April 2010= 0.0; April 2010=0.1; May 2010 & August 2010 = 0.1; September 2010=.15; Prostiscint = negative; December 2010 PSA = 0.3.

Veteran Member

Date Joined Dec 2008
Total Posts : 3149
   Posted 1/29/2011 1:29 PM (GMT -6)   
This is known stuff already as to possible risks and PCa has some mirror or overlinks to breast cancers, for comparison type issues (hormonal things etc.) BCRa1 and BCRa2 are known about. Family histories of breast or PCa has some risk factor, linkage.

There are various reasons for PCa, and various pathways to currently influence the cells, read about dendretic cells and PCa. You can find Journal Articles on such and I have read a few of them, of course I am not Mensa ready and it is over my head...but I can understand concepts to some degree, as an average caveman. Someone on here might be able to boil it down into the Kings English whereby the average USA chap might see it more clearly. He does have a way with the words, sincerely...maybe Alf has some info on this. Maybe Tony C. has more on this and some weblinks, I could find some links but not into it right now.

The vaccines like Provenge are finding ways to have dendretic cells and receptors take in certain properties to affect the PCa cells, either for apoptosis (cell death) or change the PCa DNA back to your original cell composition are some of the current theories on fixing us up.
This is no doubt the beginning of repairing soon is the question!

PCa is common in men, many never know they have it. If you live to be 80 around 80% of men would be found with some version of

Don't freak out....alot of us are just unlucky..we are influenced by environmental factors, phony food additives and hormones and less clean air and lousy diets...these contribute to PCa and other cancers. Some jobs have higher risks for contracting PCa, interesting to know about.

Post Edited (zufus) : 1/29/2011 11:34:44 AM (GMT-7)

Regular Member

Date Joined Aug 2009
Total Posts : 374
   Posted 1/29/2011 4:50 PM (GMT -6)   
Kark/Zufus.......I was told my the medical oncologist I consulted prior to surgery, that I should check into the BCRA1 & BCRA2 connection since my sister, who is 3 years younger than me, is a double mastectomy survivor of breast cancer. Add to that my mother's mastectomy, and her sister's (my maternal aunt) and we had breast cancer all over the place. When I said that I didn't have children, and didn't plan on any (so why the fuss), the oncologist pointed out that I, too, could be at risk for breast cancer if I/my sister was sporting one of those two genes. So my sister got tested, and we went together to get the results-------she wasn't carrying the one that mattered.----so there is more than just the breast-prostate connection to think about, there's also the breast-breast connection.
Arnie in DE
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