Gene test may help spot lethal prostate tumors

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pasayten
Regular Member


Date Joined Mar 2007
Total Posts : 430
   Posted 2/2/2011 7:10 PM (GMT -6)   
Article that just came out on MSN Men's Health...
 
Gene test may help spot lethal prostate tumors
 
MSN
 
Rueters
 
This looks like original source study...
 
Cheers!  pasayten
 
 
3/2007 - Dx 59 y/o - 12 point biopsy - Left 0/6 Right 1/6 Gleason 3+3 T1c
4/2007 - DaVinci RRP performed - Gleason 6 T2c Nx Mx
PSA 7/07 0.01, 6/08 0.02, 12/08 0.03, 10/09 0.13
11/09 Consult BCR and rec for SRT
1/2010 IMRT SRT - 32 sessions 2 gys for 64 gys total.
6/2010 3 mth PSA post SRT 0.02
1/2011 10 mth PSA 0.01
My Extended Signature

Post Edited (pasayten) : 2/2/2011 6:28:52 PM (GMT-7)


Magaboo
Veteran Member


Date Joined Oct 2006
Total Posts : 1210
   Posted 2/2/2011 9:50 PM (GMT -6)   
Hi Pasayten. Thanks for the heads up on this development. We can only hope that it will turn out to be another weapon against the daemon we call cancer.
Hope all is well with you.
 
Mag

Born 1936
PSA 7.9, Gleason Score 3+4=7, 2 of 8 positive
open RP Nov 06, T3a, Gleasons 3+4=7, Seminal vesicles and lymph nodes clear
Catheter out 15 Dec 06, Dry since 11 Feb 07
All PSA tests in 2007 (4) <.04
PSA tests in 2008: Mar.=.04; Jun.=.05; Sept.=.08; at SRT Start=0.1,
Salvage RT completed (33 days-66Gy) 19 Dec 08
PSA: in Jan 09 =.05, all tests to date (Jan 11) <.04

Fairwind
Veteran Member


Date Joined Jul 2010
Total Posts : 3632
   Posted 2/2/2011 11:04 PM (GMT -6)   
This is very interesting...Two years ago, a company called Health Discovery Corp developed a test called the "Four Gene Signature urine test" that can tell, from a simple urine test, if a man has PC or not. Initially, it was used in conjunction with a PSA test to determine if an abnormally high PSA number was caused by cancer..Then they discovered the test was so sensitive it could detect PC much earlier than PSA could and therefore could be used as a screening test all by itself...Trials were held and the test quickly won FDA approval. Health Discovery Corp. (a small penny stock bio-tech company) licensed the rights to the test to both Abbott labs and Quest labs.

So far, neither of these companies have made any effort to market the test...

www.healthdiscoverycorp.com/pr/feb5b_09.html

Post Edited (Fairwind) : 2/2/2011 10:16:29 PM (GMT-7)


Sleepless09
Veteran Member


Date Joined Jul 2009
Total Posts : 1267
   Posted 2/2/2011 11:20 PM (GMT -6)   
Fairwind ....

That is an amazing story.

As a business owner, I'm all for free enterprise, but there are times I really do wonder about corporate responsibility.

Geeeeesh!

Thanks for sharing this.

Sheldon AKA Sleepless
Age 67 in Apil '09 at news of 4 of 12 cores positive T2B and Gleason 3 + 3 and 5% to 25% PSA 1.5
Re-read of slides in June said Gleason 3 + 4 same four cores 5% to 15%
June 29 daVinci prostatectomy, Dr. Eric Estey, at Royal Alexandra Hospital Edmonton one night stay
From "knock out" to wake up in recovery less than two hours.  Actual surgery 70 minutes
Flew home to Winnipeg on July 3 after 5 nights in Ramada Inn  ---  perfect recovery spot!
Catheter out July 9
Final pathology is 3 + 4 Gleason 7, clear margins, clear nodes, T2C, sugeron says report is "excellent"
 
Oct 1st 09 -- dry at night, during day some stress issues.
Oct 31st padless 24/7 
 
First post op PSA Sept 09  less than 0.02
PSA on Oct 23, 2009 less than 0.02
PSA on Jan 8, 2010  less than 0.02
PSA on April 9, 2010 less than 0.02 
PSA on July 9, 2010 (one year) less than 0.02
  

Fairwind
Veteran Member


Date Joined Jul 2010
Total Posts : 3632
   Posted 2/2/2011 11:33 PM (GMT -6)   
I tried contacting all three companies..Only Quest replied..They actually took the time to find me and call me on the phone..They freely admitted they held the rights to perform the test but developing it was a back-burner issue at the moment. They had other pressing projects that they felt were more important...

Personally, I suspect there is a lot going on backstage..As Pasayten noted, other labs are developing their own tests and may try to avoid Health Discovery's patents..I'm just guessing, but this bio-tech stuff is a dog eat dog business...It's funny these two tests have exactly the same name..

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 2/3/2011 12:11 PM (GMT -6)   
Yes behind the scenes....one can imagine the greasing of palms with $$$$. Perhaps.

Post Edited (zufus) : 2/3/2011 11:15:43 AM (GMT-7)


DJBearGuy
Veteran Member


Date Joined Dec 2008
Total Posts : 714
   Posted 2/3/2011 9:42 PM (GMT -6)   
Hmm. If the test were really good, not only does it put the PSA test out of business, it takes away a lot of business from surgeons and radiologists. So what do they do?

No, I'm being too cynical...right?

Fairwind
Veteran Member


Date Joined Jul 2010
Total Posts : 3632
   Posted 2/3/2011 11:40 PM (GMT -6)   
Anytime you change the Status Quo, big waves can be generated. Millions of PSA tests are performed every year at a cost of $75-$150 each..Globally, the number is staggering..Five BILLION dollars in the U.S. alone...

The Four Gene Signature Urine Test has the potential to make routine PSA testing obsolete..

Anytime you try to change a revenue stream like that, you can expect heavy resistance.

One thing I have not been able to find out, the cost and time requirement to perform one of these tests..If the cost is prohibitive or the time factor is long, or both, that would take some of the rosy glow off this new diagnostic tool...

Getting a diagnostic test approved by the FDA, especially a non invasive urine test, is a simple matter compared to getting a new drug approved..I believe they have obtained this approval. The two labs, Abbott and Quest need to develop the actual commercial test procedure and have it approved before it is offered to the medical community..

I did stumble across this ...

www.tradingmarkets.com/news/press-release/hdvy_health-discovery-corporation-s-hdvy-ob-test-may-help-curb-the-second-leading-cause-of-cancer-death-746121.html

Post Edited (Fairwind) : 2/3/2011 11:00:04 PM (GMT-7)

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