Swapping ftom zoladex to cosadex as a mono therapy

Because of your risky stats and overall findings....my view is monitor this monthly for psa increases (walk in psa test places or however), in some high risk patients and depending upon prior ADT drugs like you did, PCa can turn AIPCa or HRPCa and casodex or its equivalents (flutamides), in some patients helped FEED PCa and added to PSA increases and sometimes very fast, that would be immediate time to cancel using it and some docs do exactly that. I have seen this event happen in many patients.

This is why you monitor it very closely, of course 'IF' you have a very wise oncologist...he should know all that and be working for your best interests and outcomes. You might do well on casodex, cannot be fully known. My own guess as having watched other patients throughout the years on forums, is that it may not work that long...thus another reason to monitor closely. Look at the website:    www.hrpca.org     (proven treatments) you will be looking at these for hopefully years and years, as some of the choices. Is this your choosing right now or is doc suggestings the casodex or its equals????

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Dx-2002 total urinary blockage, bPsa 46.6 12/12 biopsies all loaded 75-95% vol.; Gleasons scores 7,8,9's (2-sets), gland size 35, ct and bone scans look clear- ADT3 5 months prior to radiations neutron/photon 2-machines, cont'd. ADT3, quit after 2 yrs. switched to DES 1-mg, off 1+ yr., controlled well, resumed, used intermittently, resumed useage

Post Edited (zufus) : 2/5/2011 7:12:22 AM (GMT-7)

 

I am approaching the three month mark on Zoladex, ready for my second injection.  My uro surg had me on casodex two weeks prior to the Zoladex and two weeks after the injection ( as a blockade ) only.  May I ask why you would switch when there is such a drop in your PSA and a very low T after just three months?

Jack

 

Thought you might wish to know that above and this upfront.  With zometa it does help your bone density, there is also the slight worry or concern if you get jaw necrosis, as weird as that can be for using this on bone issues.

 

Knowing all you can up front is always worthwhile.

 

If you can find a psa testing facility nearby I would get tested pretty soon and see if it helps at all and that would be a clue, especially when using HD casodex at 150 mg level. I question how useful is it and is it doing harm???  Because of your overall stats and other variables, mono therapy for someone else in a different scenario could be much different and/or work fine, so that people don't get the wrong impression. PCa can morph and/or have androgen independence and be tricky on the receptors as to what happens on a cellular level. This is why the drugs, timing and useage is very strange, some patients fail psa on casodex perhaps even early on, but later in their PCa journey cycle sometimes can revist it and get a new response....it is that strange.  Protocols are tricky and that is why the specialist rule in knowing the biology of PCa, Dr. Myers, Strum, Scholz, Lam, Leibowitz, Volgezang, Yu and some others are the best in this.

Casodex is normally not associated with any type of flaring, just the opposite. It does have possible back pain, but spinal is little different. One website mentioned this:

Musculoskeletal

Musculoskeletal complaints include bone pain. This may be due to underlying disease.

So if it were in effect doing harm for PCa, then I suppose the spinal pain would be a possible clue and might even get more painful, maybe. Like I said I don't presume to know, only to question. 

Best to you.
(suggested reading:    www.hrpca.org     proven treatments)

Post Edited (zufus) : 2/10/2011 2:49:08 PM (GMT-7)