Interesting article, especially the Wall Street Journal Link that I hadn't seen before.
I suspect that many of us will have a mixture of cancer types, just as we have a range of cell types that make up the Gleason scores. And many of us have a mixture of mostly hormone-sensitive cells, and often less of the ones that ignore hormones.
Just as hormone treatment can kill off all the sensitives and leave just the refractories, I expect that treatments aimed at the type of the cancer will eventually fail for the same reasons. But such treatment should buy us some more time...
I like the analogy of a lawnmower engine (the driver of the PCa) vs a BMW V12 engine. But I think the analogy falls down big-time, because it assumes that the lawnmower will never turn into a BMW -- with PCa can we be certain?
But I'd sure love to have a real lawnmower that did that
No symptoms; PSA 5.7; Gleason 4+5=9; cancer in 4/12 cores
Non-nerve-sparing RRP 7 March 2008 age 63
Organ confined, neg margins. Gleason downgrade 4+4=8
Bimix worked well; now using just VED
PSA undetectable at first but now 0.4, doubling time 7 months
No radiation but ADT coming unless I can slow down the rise...