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James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4463
   Posted 2/9/2011 4:41 PM (GMT -6)   
She says:
I'm really hoping someone on here can help me.

My father was diagnosed with prostate cancer 4 years ago. He has had surgery and follow up therapy afterwards. He's gone from monthly to 3 monthly implants and overall has kept very well. For a short while he did without the implants but a rise in his PSA prompted the doctor to start these again.

Over the last few months he's had problems urinating (one of his original symptoms) but the doctors felt that this was more to do with scar tissue from his earlier surgery rather than a problem with his prostate.

Last week he had further surgery to widen his "tube" as he calls it, and the flow is back to normal - unfortunately he had a call today with the results of a blood test taken last week and his PSA is 26 (previously 9)

I was wondering if a PSA level could increase as a result of surgery? It really knocks him for six when he gets news like this, especially when they just call to drop this bombshell but don't offer any explanation for the sudden rise. He has a hospital appointment next week but I know he's going to be distraught and depressed until he goes there. I'd like to be able to offer him some alternative reasons for this increase but don't know enough about it to do that.

Help....please....

James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4463
   Posted 2/9/2011 4:43 PM (GMT -6)   
Welcome to the Forum.

A couple questions, what are the implants you are talking about? Radioactive seeding? Not heard that term before with post surgery.

Also, I don't think the procedures and exams will drive PSA up that much once the prostate is gone.
James C. Age 63
Gonna Make Myself A Better Man tinyurl.com/28e8qcg
4/07: PSA 7.6, 7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS6
9/07: Nerve Sparing open RP, Path: pT2c, 110 gms., clear except:
Probable microscopic involvement-left apical margin -GS6
3 Years: PSA's .04 each test until 04/10-.06, 09/10-.09, 01/11-.09
ED-total-Bimix 30cc

Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 2/9/2011 6:06 PM (GMT -6)   
Hello, and welcome. Sorry about your father. I have had 6 corrective surgeries like his, and none of them would make someone's PSA rise, there is no connection there. As James above askes, we need clarification about the "implants" you are talking about in order to understand his situation better.

Good luck and keep us posted,

David in SC
Age: 58, 56 dx, PSA: 7/07 5.8, 10/08 16.3
3rd Biopsy: 9/08 7 of 7 Positive, 40-90%, Gleason 4+3
open RP: 11/08, on catheters for 101 days
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos marg
Incont & ED: None
Post Surgery PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, 8/6 .06 11/10 Not taking it
Latest: 6 Corr Surgeries to Bladder Neck, SP Catheter since 10/1/9, SRT 39 Sess/72 gy ended 11/09, 21 Catheters, Ileal Conduit Surgery 9/23/10

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 2/9/2011 6:08 PM (GMT -6)   
Zoladex would likely be his implants, HT therapy via LHRH drug, also called ADT therapy for newbies. I am guessing he got monthly injections on this(subcataneous injection like pellet) then switched to 3 month version. With a rise in psa with LHRH in this scenario is not great news. Verify the injection is it Zoladex or other similar. If he has rising PSA while on this injection drug and especially at 26 that is somewhat worrisome. (it wasn't totally clear to me where you stand in treatments above, maybe you can come back with replies). 
 
If he just got back on Zoladex or implant LHRH, then his psa should drop back down as the drug does its duty. If not then there are other drugs for PCa that can work when these LHRH drugs fail, see   www.hrpca.org   (proven treatments)
 
Info sites: www.yananow.net           www.prostate-help.org      www.phoenix5.org 

Learn all you can to be helpful.  Learn about hrpca and how it is monitored and handled.
 
Start looking for a PCa specialist in oncology.....the biology of PCa and how to treat it. This is way beyond the scope of a urologist and his expertise level, so giving you a heads up.
 
There are various treatments for PCa, so do not let him give up hope.
Dx-2002 total urinary blockage, bPsa 46.6 12/12 biopsies all loaded 75-95% vol.; Gleasons scores 7,8,9's (2-sets), gland size 35, ct and bone scans look clear- ADT3 5 months prior to radiations neutron/photon 2-machines, cont'd. ADT3, quit after 2 yrs. switched to DES 1-mg, off 1+ yr., controlled well, resumed, used intermittently, resumed useage

Post Edited (zufus) : 2/9/2011 4:35:14 PM (GMT-7)


zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 2/10/2011 12:15 PM (GMT -6)   
Bumped and Rebumped and Les has restarted this on another thread too!
Dx-2002 total urinary blockage, bPsa 46.6 12/12 biopsies all loaded 75-95% vol.; Gleasons scores 7,8,9's (2-sets), gland size 35, ct and bone scans look clear- ADT3 5 months prior to radiations neutron/photon 2-machines, cont'd. ADT3, quit after 2 yrs. switched to DES 1-mg, off 1+ yr., controlled well, resumed, used intermittently, resumed useage
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