Also, you may be thinking of the 2008 study by Trock that showed men with fast doubling time got the most survival benefit from SRT. My understanding is because men with slow doubling times weren't at high risk for dying from their recurrence, so SRT did not improve their survival (because it was already high). A subset of men with fast doubling times got the most bang for their SRT because their cancer was still localized.
Walsh was surprised about
"I found the results of this study remarkable," says Patrick C. Walsh, M.D., University Distinguished Service Professor of Urology at the Brady Urological Institute. "Previously, we believed that these men -who have aggressive disease defined by a rapid doubling of PSA in six months or less -- had distant metastases and would not benefit from any form of local salvage therapy."
(Personal comment: I was aware of these older recommendations when I went to meet my radiation oncologist the first time, and I was quite worried with my fast doubling time I'd go through SRT for nothing)
Some leading radiation oncologists (Dana-Farber, Harvard) commented:
"...we are also offering salvage radiotherapy to more patients with short doubling times and other unfavorable features, as the data suggest that there may be a group of patients with aggressive and rapidly progressing disease that remains localized to the prostate bed and that can be effectively salvaged by radiotherapy."
Dx Feb 2006, PSA 9 @age 43
RRP Apr 2006 - Gleason 3+4, T2c, NX MX, pos margins
PSA 5/06 <0.1, 8/06 0.2, 12/06 0.6, 1/07 0.7.
Salvage radiation (IMRT) Jan-Mar 2007
PSA 9/2007 and thereafter <0.1pcabefore50.blogspot.com