scientists believe that by reducing ERK5 levels, the aggressive spread of the cancer may be....

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BobCape
Regular Member


Date Joined Jun 2010
Total Posts : 416
   Posted 2/12/2011 7:20 PM (GMT -6)   
A report some may want to read.
 
"Using cells grown in the laboratory to mimic the action of cancer cells invading in the body, they discovered that ERK5 was driving the aggressive behaviour of the cancers. When levels of ERK5 were artificially reduced or prevented from working as well, they were able to reduce the cancerous invasion of other cells."

THE PART I DON'T GET!!!!!!!!!!!!!

"They predict that clinical trials of drugs that will attack ERK5 will start in patients within five years"
 
FIVE YEARS, RU crapTING ME? I THINK WERE THE 2ND LARGEST CANCER IN THE COUNTRY FOR ME AND WE DONT HAVE AS LOBBY THAT CAN TELL THEM "5 YEARS IS TOOOOOOOOOO LONG crapHEADS!"
 
Go ahead, ban me.
 
Thoughts and prayers to all of you. You are not alone.
 

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 2/13/2011 5:31 AM (GMT -6)   
Wait till you see how much it costs to run clinical trials and have backing to even get to Phase I or II, whereby alot of them run out of funding or enthusiam or whatever. To go to Phase III and hopefully Phase IV takes huge money and moxy. Priorities for these investors companies is a big deal and consideration, reality of the situation.

No banning....mods call it venting....and...rave....it is a side effect of being a PCa patient.

Hopefully our foreign competitors will make the necessary inventions before we do.
Dx-2002 total urinary blockage, bPsa 46.6 12/12 biopsies all loaded 75-95% vol.; Gleasons scores 7,8,9's (2-sets), gland size 35, ct and bone scans look clear- ADT3 5 months prior to radiations neutron/photon 2-machines, cont'd. ADT3, quit after 2 yrs. switched to DES 1-mg, off 1+ yr., controlled well, resumed, used intermittently, resumed useage

John T
Veteran Member


Date Joined Nov 2008
Total Posts : 4223
   Posted 2/13/2011 11:27 AM (GMT -6)   
The same bureaucratic process that keeps bad drugs off the market also prevents new drugs and devices from being rapidly introduced.
Provenge was proven effective in 2003 and we are just seeing it in limited quantities today. They were working on PCA3 about 12 years ago and it is just becoming mainstream. The things you read about today, if they are ever introduced, it will be at least 10 years before we can use them.
JohnT
65 years old, rising psa for 10 years from 4 to 40; 12 biopsies and MRIS all negative. Oct 2009 DXed with G6 <5%. Color Doppler biopsy found 2.5 cm G4+3. Combidex clear. Seeds and IMRT, no side affects and psa .1 at 1.5 years.

Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25380
   Posted 2/13/2011 11:58 AM (GMT -6)   
...which won't do most of us in this tier of Prostate Cancer Victims a whole lot of good.

compiler
Veteran Member


Date Joined Nov 2009
Total Posts : 7203
   Posted 2/13/2011 1:44 PM (GMT -6)   
I wonder if there is anything big on the horizon for the next 2-3 years? I thought there was talk of trying provenge at an earlier stage. Of course, it might be hard to get volunteers ... or maybe not so hard after curative bullets have been unsuccessfully used.
 
Mel

ChrisR
Veteran Member


Date Joined Apr 2008
Total Posts : 825
   Posted 2/13/2011 2:13 PM (GMT -6)   
You see this crap all time. "We are expecting clinical trials in "x" years." And then we never hear from them again. What these guys are saying is a load of it. They will never get this to market. They published their research paper and we wont hesr from them again. Just like all the other "break throughs" we read about.
Dx @ 42 years old on 4/2008
Gleason 6 (50 Point Biopsy) (6 Cores positive - Small Focus Each)
open RP 10/08 Johns Hopkins
pT2 Organ Confined Gleason 6 (tertiary score 0)
PSA Since Surgery
1/15/2009 (3 Month) <.1
10/15/2009 (1 Year) <.1
10/15/2010 (2 Year) <0.03
10/15/2011 (3 Year) -

mr bill
Veteran Member


Date Joined Sep 2010
Total Posts : 688
   Posted 2/13/2011 4:37 PM (GMT -6)   
Do you think it might have anything to do with the resarch/grant money that may be available? We wouldn't want to think that money drives the industry, would we.

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 2/13/2011 5:42 PM (GMT -6)   
Likely approval for Abiraterone within 1+ years
Likely approval for MDV3100 - called super casodex within 1-2 years (has two different Phase III trials on it)

Possible approval for DCVax (another vaccine to compete with Provenge), they claim it is different and superior, who knows???

Canadians have different sorts of vaccines for other ailments in the pipeline right now and may have one designed for PCa soon, too.

There are many others that might come to useage, some bone density drugs in Trials still.
 
 

Jerry L.
Veteran Member


Date Joined Feb 2010
Total Posts : 3055
   Posted 2/13/2011 6:42 PM (GMT -6)   
Just curious, when was Abiraterone first talked about?  It seems that they moved relatively quickly on this?

BobCape
Regular Member


Date Joined Jun 2010
Total Posts : 416
   Posted 2/13/2011 7:24 PM (GMT -6)   
I understand that.
How many resources do they plan to waste, how much corporate revenue do they hope to raise, that they already know it will be 5 years before they even start on patients.

Sounds like alot of peple earning good salaries for 5 years... while PLENTY of people DIE, and PLENTY of resources are wasted.

I understand the concept ... But I just finished receiving 66 gys of radiation that might very well itself cause me cancer. So it's a little more complex than that.

Guess i'd just like to see a little more sense of urgency when people with prostate cancer die every day of the year in this country... not in 5 years. NOW.

Jerry L.
Veteran Member


Date Joined Feb 2010
Total Posts : 3055
   Posted 2/13/2011 7:57 PM (GMT -6)   
At work I lead teams to solve IT problems (some big/some small) and manage projects, many times discovering and implementing new technologies. We do this through a team approach. We follow a project plan, assign team members, identify responsiblities, etc... all things project management...The bottom line is that things get done because it is orderly and everyone knows their role and we all work towards the common goal.


Now, I realize that curing PC is a huge project...but there just doesn't seem to be one authority in charge of leading and solving this problem. If I am incorrect, please let me know who this is, and where I can access the project plan, timeline, status, etc...

Post Edited (Jerry L.) : 2/13/2011 7:41:51 PM (GMT-7)


Fairwind
Veteran Member


Date Joined Jul 2010
Total Posts : 3741
   Posted 2/13/2011 10:41 PM (GMT -6)   
ERK5, 2006

www.nature.com/embor/journal/v7/n8/abs/7400755.html

Seems to me, The System has to be changed..When people have a terminal illness like metastasized PC, and a promising new drug or treatment has passed a quick testing program for it's basic safety and or toxicity, then people who volunteer to try this drug or treatment should be free to do so..I mean, what do they have to lose?

Today, in Chemo Lounges all around the country, thousands of people had vile poisons infused into them, paying thousands of dollars, in the hopes of curing or at least slowing down their cancers..Becoming a guinea pig for a hopeful new drug can't be any worse...It's not like you were going to give it to healthy school kids...

Post Edited (Fairwind) : 2/13/2011 9:57:01 PM (GMT-7)


zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 2/14/2011 5:47 AM (GMT -6)   
Info on Abiraterone:
As the results of the early stage trials were published in the Journal of Clinical Oncology, abiraterone instantly gained rave reviews as the miracle drug to treat prostate cancer. The mainstream media immediately pounced on the story during the middle of July 2008, hailing the drug as the most significant development in the field of prostate cancer therapy in 70 years...

Phase I results were announce back around July 2008 approx., so it started before that. But, basically this drug got fast tracked compared to some. Johnson & Johnson is the mfg. owner on this drug, it is alot like Ketoconazole but is said to be 10 times as powerful, but without 10 times the side effects. Keto was approved like in 1981, way back but not as PCa drug, but an anti-fugal type drug, the Canadians (bless the neighbors they are) found out on off lable use, it worked at controlling PCa and thus it evolved into off label use for a different ailment. That is the good side of FDA approval items, once approved you have a chance to try it on other ailments. I think it helped in faster tracking that it was similar to Keto which is still used now for 30 years. It seems it will be another useful tool in fighting PCa and also MDX3100 (MDV3100) super casodex looks promising and might be another one that makes it within 1-2 years.

You can get this drug right now without FDA approval, through Dr. Scholz and Lam in California, they have some kind of arrangement with Johnson & Johnson. You would have to call their office and find out how that works. This was mentioned by Mark Moyad in the Dec. Paact Newsletter and he is the guy who knows about non FDA possibilities with PCa drugs.
Dx-2002 total urinary blockage, bPsa 46.6 12/12 biopsies all loaded 75-95% vol.; Gleasons scores 7,8,9's (2-sets), gland size 35, ct and bone scans look clear- ADT3 5 months prior to radiations neutron/photon 2-machines, cont'd. ADT3, quit after 2 yrs. switched to DES 1-mg, off 1+ yr., controlled well, resumed, used intermittently, resumed useage

Jerry L.
Veteran Member


Date Joined Feb 2010
Total Posts : 3055
   Posted 2/14/2011 2:15 PM (GMT -6)   
Zufus,
 
Thanks for the info...Do we know anyone that is trying Abiraterone early?

Jerry L.
Veteran Member


Date Joined Feb 2010
Total Posts : 3055
   Posted 2/14/2011 5:56 PM (GMT -6)   

To answer one of my previous questions - I believe the Prostate Cancer Foundation seems to be one of the more reputable authorities in the fight...

http://www.pcf.org/site/c.leJRIROrEpH/b.5699537/k.BEF4/Home.htm

 

 

 


zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 2/14/2011 5:58 PM (GMT -6)   
David Emerson I believe is using this or was, would have to find out. Another prostate group at www.hrpca.org (special group) had some people already using it. Will have to try and find out how they are fairing with its results. Side effects are likely similar to Ketoconazole and you can read about them. Keto is actually inexpensive which is a plus, but some patients dropped it cause of side effects, others said it was not to bad or endured some side effects well enough. HD Keto is used with prednisone (a steriod) for best results and you have to take it on daily time periods.

I heard you can get MDV3100 in Virginia somehow, maybe that was through something Dr. Myers had lined up, would have to look into that too.
Dx-2002 total urinary blockage, bPsa 46.6 12/12 biopsies all loaded 75-95% vol.; Gleasons scores 7,8,9's (2-sets), gland size 35, ct and bone scans look clear- ADT3 5 months prior to radiations neutron/photon 2-machines, cont'd. ADT3, quit after 2 yrs. switched to DES 1-mg, off 1+ yr., controlled well, resumed, used intermittently, resumed useage

Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 2/14/2011 6:07 PM (GMT -6)   
Zufus,
You are correct, David is in the trial. If anyone would like to talk to him, he's a great guy is always lending a helping hand...here is his blog, you can write him there or let me know I can put you in contact with him. We are currently planning a July get together in Kansas to see Kenny Chesney and Zac Brown...We should be able to explain away the effects of Abiraterone combined with country music...:-)

prostatecancerat42.blogspot.com


Jerry,
Abiraterone has not been approved for early use as yet. There is I believe just one more trial to go before general release which I think will happen in 2011. At that point we may see more trials for early and adjuvant use of the drug.

Tony
Advanced Prostate Cancer at age 44 (I am 48 now)
pT3b,N0,Mx (original PSA was 19.8) EPE, PM, SVI. Gleason 4+3=7

Treatments:
Da Vinci Surgery ~ 2/17/2007
Adjuvant Radiation Therapy ~ IMRT Completed 8/07
Adjuvant Hormone Therapy ~ 28 months on Casodex and Lupron.
Undetectable PSA.

Blog: www.caringbridge.org/visit/tonycrispino
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