PSA scores and concerns

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New Member

Date Joined Feb 2011
Total Posts : 3
   Posted 3/1/2011 2:21 PM (GMT -6)   
Last fall my PSA was 7.0, two weeks later it was 5.05, 90 days later it was 6.9 with PSA 2 at .015. What should I make of this and should I be concerned? I'm scheduled for biopsy in 5 weeks.

Veteran Member

Date Joined Feb 2010
Total Posts : 3771
   Posted 3/1/2011 2:45 PM (GMT -6)   
you should be concerned but remember that you have about a 33% chance of having prostate cancer at this point.  my first ever PSA was 6.8 and a month later my PSA was 6.1.  the biopsy showed 12/12 core positive for PC.  good luck to you.  remember that there's a better chance that you don't have cancer.
age: 55
PSA on 12/09: 6.8
gleason 3+4 = 7
received 3rd and last lupron shot 9/14/10
2/8/11 PSA <.1, T= 6 ng/dl

Veteran Member

Date Joined Apr 2008
Total Posts : 847
   Posted 3/1/2011 3:13 PM (GMT -6)   
Hi MSretiree and welcome to the forum.

I'm not sure about this part of your post referring to PSA 2 at .015.
MSretiree said...
90 days later it was 6.9 with PSA 2 at .015.
Maybe that means a free PSA of 15%?

Regardless of that, your PSA is highish and fluctuating. Fluctuations are quite common, so are nothing to be concerned about. Generally your PSA will trend upwards as you age and your prostate enlarges -- if you have a large prostate, a PSA around 7 may be normal for you.

It's a good move to have a biopsy. You have reason to be concerned at this point, but it is by no means certain that you have PCa. Good luck with the biopsy.
No symptoms; PSA 5.7; Gleason 4+5=9; cancer in 4/12 cores
Non-nerve-sparing RRP 7 March 2008 age 63
Organ confined, neg margins. Gleason downgrade 4+4=8
Fully continent
Bimix worked well; now using just VED
PSA undetectable at first but now 0.4, doubling time 7 months
No radiation but ADT coming unless I can slow down the rise...

New Member

Date Joined Feb 2011
Total Posts : 3
   Posted 3/1/2011 4:07 PM (GMT -6)   
Oops. I did the numbers from memory and just checked the report. Total PSA 6.55, Free PSA 1.01, PSA ratio 0.15. By the way, the doc told me I had a large prostate in the initial screening. I took that to mean big, not enlarged.

Thanks to both of you for the quick response. This has been a shock from someone who has NEVER been sick. Worked 42 years and missed 1.5 days to illness in the last two years of the 42.

Thanks again.

Elite Member

Date Joined Oct 2008
Total Posts : 25355
   Posted 3/1/2011 5:15 PM (GMT -6)   
Welcome, and good luck, the biopsy at this point is a good idea in my opinion.
Age: 58, 56 dx, PSA: 7/07 5.8, 10/08 16.3
3rd Biopsy: 9/08 7 of 7 Positive, 40-90%, Gleason 4+3
open RP: 11/08, on catheters for 101 days
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos marg
Incont & ED: None
Post Surgery PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, 8/6 .06 11/10 Not taking it
Latest: 6 Corr Surgeries to Bladder Neck, SP Catheter since 10/1/9, SRT 39 Sess/72 gy ended 11/09, 21 Catheters, Ileal Conduit Surgery 9/23/10

Regular Member

Date Joined Dec 2010
Total Posts : 119
   Posted 3/2/2011 8:00 AM (GMT -6)   
Good luck to you on your biopsy. It is a good that your doctor is going to do it.

Like started above PSA can fluctuate, but also the lab technician can have different readings from the same sample. PSA is not an exact measurement in the lab. I read somewhere as my PSA changed that 0.5 difference in readings have been seen.
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