University of Michigan study shows hope in treatment of aggressive form of prostate cancer

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MichGuy
Regular Member


Date Joined Jan 2009
Total Posts : 51
   Posted 3/2/2011 3:26 PM (GMT -6)   
Maybe this offers some hope to those here with more aggressive cancer: 
 

In the new study, mice with the aggressive form of cancer were treated with an antibody for SPINK1.

“Your body makes antibodies in response to infections or foreign proteins,” Tomlins said. “It’s the basis for immunity. By injecting proteins (like SPINK1) into a mouse, the mouse will make an antibody for that protein.”

The antibody, which has not yet been developed for human use, shrunk the tumors in mice by 60 percent. When researchers injected mice with an already FDA-approved drug called cetuximab, tumors were reduced by 40 percent. When the SPINK1 antibody and cetuximab were injected together, the tumors shrunk by 74 percent. These results were only true for tumors that expressed the SPINK1 gene.


Magaboo
Veteran Member


Date Joined Oct 2006
Total Posts : 1211
   Posted 3/2/2011 5:23 PM (GMT -6)   
Hi MichGuy,
With all the successful treatments they have found for mice, it is a wonder that any mice, with cancer, are left to experiment on :-) . Now if they could only find something that would works on us humans.
Thanks for your interesting post.
All the best to you.
Mag

Born 1936
PSA 7.9, Gleason Score 3+4=7, 2 of 8 positive
open RP Nov 06, T3a, Gleasons 3+4=7, Seminal vesicles and lymph nodes clear
Catheter out 15 Dec 06, Dry since 11 Feb 07
All PSA tests in 2007 (4) <.04
PSA tests in 2008: Mar.=.04; Jun.=.05; Sept.=.08; at SRT Start=0.1,
Salvage RT completed (33 days-66Gy) 19 Dec 08
PSA: in Jan 09 =.05, all tests to date (Jan 11) <.04

MichGuy
Regular Member


Date Joined Jan 2009
Total Posts : 51
   Posted 3/2/2011 8:19 PM (GMT -6)   
Yeah Mag, if only!  I didn't dare mention the experiments they are doing with mice and pomegranate juice... nono
Best to you, too!
 
MichGuy

Fairwind
Veteran Member


Date Joined Jul 2010
Total Posts : 3889
   Posted 3/3/2011 11:47 AM (GMT -6)   
What's really sad is that it seems to take at least 10 years to move from mice to humans...I just don't understand it..If the new treatment passes some basic toxicity tests, what's the problem with testing it on terminal cancer patients who volunteer to be treated??
Age 68.
PSA age 55: 3.5, DRE normal.
age 58: 4.5
61: 5.2
64: 7.5, DRE "Abnormal"
65: 8.5, " normal", biopsy, 12 core, negative...
66 9.0 "normal", 2ed biopsy, negative, BPH, Proscar
67 4.5 DRE "normal"
68 7.0 3rd biopsy positive, 4 out of 12, G-6,7, 9
RALP Sept 3 2010, pos margin, one pos vesicle nodes neg. Post Op PSA 0.9 SRT, HT. 2-15-'11 PSA 0.0
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