PSA drops a little after SRT - too soon to celebrate?

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Carlos
Regular Member


Date Joined Nov 2009
Total Posts : 486
   Posted 3/4/2011 7:31 AM (GMT -6)   
My PSA dropped to 0.1 three weeks after finishing SRT.   The last check prior to SRT was 0.2.  Is this just analytical error or can I celebrate a little?  I found a lot of info on PSA kinetics after primary RT but not a thing for SRT.  I suppose the only difference would be a lower range of PSAs.  I will get a recheck in three weeks when I go back to the doc.
 
Carlos
Dx 2/2008, age 71, PSA 9.1, G8,T1c. daVinci surgery 5/2008, G8(5+3), pT2c. LFPF, good QOL. PSA <0.1 for 2 yrs. PSA rose to .2 at 30 months, Completed SRT 2/2011. PSA 0.1 at 3 wks post SRT.

60Michael
Veteran Member


Date Joined Jan 2009
Total Posts : 2243
   Posted 3/4/2011 8:22 AM (GMT -6)   
Carlos, you cut the PSA in half in only 3 weeks so that and the downward trend are your friends. Think I waited 6-8 weeks for my SRT PSA and did not do as well as you. Celebrate later, just feel positive at this point.
Michael

JNF
Veteran Member


Date Joined Dec 2010
Total Posts : 3888
   Posted 3/4/2011 8:25 AM (GMT -6)   
Carlos,

I celebrate every piece of news that I percieve to be positive. Who knows what it will do in the future, but don't fret now. I know I have a long way to go with this stuff and that there will be some days of not so good news.

I just finished radiation eight weeks ago and am on HT and my first reading was <0.1. I am not going to fantasize that it will always be there, but for now it looks like things are working and I am in the lead.....last fall the PCa was in the lead.

We see some people having cures and many having very long remissions. I view my situation that an absolute cure is not to be expected, but a very long effective management is in order. Every low reading supports that. I am expecting to get the Radiation Flare at about 18 months unless it is masked by the HT.

In your case I would think that with no prostate there isn't much to give you a flare, so you should be getting a clear assessment of how things are going. Remember that radiation takes a longer time to kill the cells as it mainly damages them and hopefully weakens them enough to prevent division.

Best wishes for the next reading

Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25394
   Posted 3/4/2011 11:33 AM (GMT -6)   
Carlos, a drop is a drop, a good starting point. The one thing I learned in the world of SRT, and 4 doctors have confirmed this opinion, is that unlike RT as a primary treatment, with SRT, there is no bounce up, and there should never be a rise at any point. Mine went down twice, which was encouraging, then made a 50% jump, then my lastest shocker, a 2000% increase, this was all within 15 months of ending SRT. It has now been officially declared a failed attempt.

On your number, I would stay positive, nice drop, and hopefully over the next 2 readings, you will see further drops. I wish you all the best.

David
Age: 58, 56 dx, PSA: 7/07 5.8, 10/08 16.3
3rd Biopsy: 9/08 7 of 7 Positive, 40-90%, Gleason 4+3
open RP: 11/08, on catheters for 101 days
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos marg
Incont & ED: None
Post Surgery PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, 8/6 .06 11/10 Not taking it
Latest: 6 Corr Surgeries to Bladder Neck, SP Catheter since 10/1/9, SRT 39 Sess/72 gy ended 11/09, 21 Catheters, Ileal Conduit Surgery 9/23/10

Magaboo
Veteran Member


Date Joined Oct 2006
Total Posts : 1211
   Posted 3/4/2011 1:23 PM (GMT -6)   
Hi Carlos. According to my Oncologist, a 50% drop in PSA, so soon after completion of SRT, is a good sign that the radiation has found it's intended target. I had a similar result after my SRT and the result thus far has been good. Hopefully your PSA will go down further in the month to follow. Best of luck to you.
 
Mag

Born 1936
PSA 7.9, Gleason Score 3+4=7, 2 of 8 positive
open RP Nov 06, T3a, Gleasons 3+4=7, Seminal vesicles and lymph nodes clear
Catheter out 15 Dec 06, Dry since 11 Feb 07
All PSA tests in 2007 (4) <.04
PSA tests in 2008: Mar.=.04; Jun.=.05; Sept.=.08; at SRT Start=0.1,
Salvage RT completed (33 days-66Gy) 19 Dec 08
PSA: in Jan 09 =.05, all tests to date (Jan 11) <.04

Carlos
Regular Member


Date Joined Nov 2009
Total Posts : 486
   Posted 3/4/2011 1:46 PM (GMT -6)   
Thanks very much for the replies.  It looks like PSA after SRT really isn't any different than after sugery.  Even if it goes into remission there isn't any way of knowing if it will stay in remission.  After my first post surgery PSA my uro told me to plan on getting tested the rest of my life.  I guess he wasn't kidding.
 
Mag, you and I are about the same age.  While none of us want to have to deal with a recurrence, it seems that by the mid seventies, the need to do something becomes a lot less urgent than for the young guys like Tony, Alf, Gordy, Galileo and many orthers on the forum. 

Gordy
Veteran Member


Date Joined Jun 2005
Total Posts : 528
   Posted 3/4/2011 3:19 PM (GMT -6)   
Young guy??? LOL

Thanks, but at 67 and with no hope or expectation of cure, or even of remission, I feel as though I'm pretty close to the end of the line. So being chronologically younger than you doesn't do it for me.

Carlos
Regular Member


Date Joined Nov 2009
Total Posts : 486
   Posted 3/4/2011 3:31 PM (GMT -6)   
Sorry Gordy.  Just got you mixed up with one of the other younger guys.  My memory is bad enough as it is now, hate to think what it would be like with prolonged HT.  My wife calls it CRS (can't remember ****).
 
Carlos
 
 

Gordy
Veteran Member


Date Joined Jun 2005
Total Posts : 528
   Posted 3/4/2011 3:35 PM (GMT -6)   
Carlos- No need to apologize - I am younger than you.

There's another malady which goes along with CRS, called CRAFT (can't remember a *****g thing).

Ed C. (Old67)
Veteran Member


Date Joined Jan 2009
Total Posts : 2461
   Posted 3/4/2011 9:24 PM (GMT -6)   
Carlos,
A drop in such a short time after SRT is good news. My understanding from those who had SRT, it will take a while before it reaches its nadir. The trend is in the right direction.
Age: 67 at Dx on 12/30/08 PSA 3.8
2 cores out of 12 were positive Gleason (4+4)
Davinci surgery 2/9/09 Gleason 4+4 EPE,
Margins clear, nerve bundles removed
Prostate weighed 57 grams 10-20% involved
all PSA tests since (2, 5, 8, 11, 15, 18, 21 months) undetectable
Latest PSA test (2 years) <.008 ?

Carlos
Regular Member


Date Joined Nov 2009
Total Posts : 486
   Posted 3/5/2011 7:20 AM (GMT -6)   
Ed, thanks for the reply.  I noticed in your profile that you had both nerve bundles removed.  The nerve bundles may have been my problem as my surgeon spared both of them.  Consequently my nerve bundles were one of the four radiation target areas.  Hopefully we nailed it.
 
Thanks, Carlos
Dx 2/2008, age 71, PSA 9.1, G8,T1c. daVinci surgery 5/2008, G8(5+3), pT2c. LFPF, good QOL. PSA <0.1 for 2 yrs. PSA rose to .2 at 30 months, Completed SRT 2/2011. PSA 0.1 at 3 wks post SRT.

Ed C. (Old67)
Veteran Member


Date Joined Jan 2009
Total Posts : 2461
   Posted 3/5/2011 12:14 PM (GMT -6)   
Carlos,
I have a feeling that removing the nerve bundles for those with high Gleason may be helpful. I asked this question a while back and the responses were that it didn't make a difference. I still believe that I did the right thing. I can live with trimix as long as the cancer stays away. Good luck.
Age: 67 at Dx on 12/30/08 PSA 3.8
2 cores out of 12 were positive Gleason (4+4)
Davinci surgery 2/9/09 Gleason 4+4 EPE,
Margins clear, nerve bundles removed
Prostate weighed 57 grams 10-20% involved
all PSA tests since (2, 5, 8, 11, 15, 18, 21 months) undetectable
Latest PSA test (2 years) <.008 ?

Fairwind
Veteran Member


Date Joined Jul 2010
Total Posts : 3895
   Posted 3/5/2011 12:45 PM (GMT -6)   
In our situation, anytime the PSA goes down, you celebrate....! Cheers! turn yeah
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