Making a new urethra - News story

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English Alf
Veteran Member


Date Joined Oct 2009
Total Posts : 2216
   Posted 3/8/2011 4:30 AM (GMT -6)   
Given that all those who have had surgery have had about two inches of urethra removed and some have had theirs damaged by radiation etc. is there any chance that guys who have been treated for PCA could be or should be offered a graft to replace/repair things? I just ask as the BBC and others are today reporting the sucess of this new idea.

www.bbc.co.uk/news/health-12666171

This is a quote from the article, and David might be interested to note the last sentence of the quote:

"The world's first tissue-engineered urinary tubes or urethras, grown in the lab using patients' own cells, have been hailed a success by medical experts.

US surgeons have used the lab-grown tubes to treat five Mexican boys with damaged urinary tracts.

They told the Lancet that all of the boys are now fit and that the grafts have taken and repaired the defects.

The same team has already managed to grow new bladders for patients."


Sounds almost too good to be true.

Alf
Born Jun ‘60
Apr 09 PSA 8.6
DRE neg
Biop 2 of 12 pos
Gleason 3+3
29 Jul 09 DaVinci AVL-NKI Amsterdam
6 Aug 09 Cath out
PostOp Gleason 3+4 Bladder neck & Left SVI -T3b
No perin’l No vasc invasion Clear margins
Dry at night
21 Sep 09 No pads daytime
17 Nov 09 PSA 0.1
17 Mar 10 PSA 0.4 sent to RT
13 Apr CT
66Gy 28 Apr to 11 Jun 10
Tired + weird BMs
14 Sep 10 PSA <0.1
12 Jan 11 PSA <0.1
Erection OK

An38
Veteran Member


Date Joined Mar 2010
Total Posts : 1149
   Posted 3/8/2011 5:26 AM (GMT -6)   
Amazing!

I understand from my reading that the lengeth of the urethra the surgeon has to play with after removing the prostate has a strong bearing on the level of incontinance.

I am just imagining the scenario where the urologist grows the urethra in the lab and uses it during the surgery to extend the urethral length thus improving outcome. Wouldn't that be great??

An
Husband's age: 52. Sydney Australia.
Family history: Mat. grandfather died of PC at 72. Mat. uncle died of PC at 60. He has hereditary PC.
PSA: Aug07 - 2.5|Feb08 - 1.7|Oct09 - 3.67 (free PSA 27%)|Feb10 - 4.03 (free PSA 31%) |Jun10 - 2.69. DRE normal.
Biopsy 28Apr10: negative for a diagnosis of PC however 3 focal ASAPs “atypical, suspicious but not diagnostic” for PC. Review of biopsy by experienced pathologist, 1/12 core: 10% 3+3 (left transitional), 1/12 core: ASAP (left apex)
Nerve sparing RP, 20Aug10 with Dr Stricker. Post-op path: 3+4 (ISUP 2005). Neg (margins, seminal vesicles, extraprostatic extension). Multifocal, with main involvement in the fibro-muscular zone. T2C.
Post RP PSA,
Lab 1: Sep10 – 0.02|Nov10 – 0.03|Dec10 – 0.03|Feb10 – 0.03
Lab 2: Nov 10 - 0.01|Dec10 – 0.01|Feb10 – 0.01

Paralleli
Regular Member


Date Joined Jul 2008
Total Posts : 123
   Posted 3/9/2011 10:30 PM (GMT -6)   
Cool! Let me know when they can do a brian. I'm in the market......
IMRT 1/07 - Doing well.

Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25380
   Posted 3/9/2011 10:47 PM (GMT -6)   
Alf, does sound too good to be true, I read the article earlier, but sounds promising for the future. Unfortanately, for me, even that technology is too late in my case, even if a new bladder could be replaced in me, my new urinary system is not reversible. Good article though.

David
Age: 58, 56 dx, PSA: 7/07 5.8, 10/08 16.3
3rd Biopsy: 9/08 7 of 7 Positive, 40-90%, Gleason 4+3
open RP: 11/08, on catheters for 101 days
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos marg
Incont & ED: None
Post Surgery PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, 8/6 .06 2/11 1.24
Latest: 6 Corr Surgeries to Bladder Neck, SP Catheter since 10/1/9, SRT 39 Sess/72 gy ended 11/09, 21 Catheters, Ileal Conduit Surgery 9/10,

reachout
Veteran Member


Date Joined May 2009
Total Posts : 725
   Posted 3/10/2011 11:06 AM (GMT -6)   
Interesting, I never thought about that much of the urethra having been removed. Makes sense, though, since it passed through the prostate. So does the bladder move down to make up the difference, or does the remaining urethra stretch out?
Age: 66
Pre-surgery PSA: 7 tests over 2 years bounced around from 2.6 to 5.6
Biopsy 8 of 12 positive, Gleason 3+4, T2a
DaVinci August 2009, pathology Gleason 4+3, neg margins, T2c
Post-surgery PSA one year of zeros.
Continent right away.
Viagra and other pills only gave me headache
Trimix working great!
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