Trazodone (Desyrel) for ED, your comments please?

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Regular Member

Date Joined Jan 2011
Total Posts : 126
   Posted 3/9/2011 3:08 PM (GMT -7)   
Hi guys,
I was stumbling around the web like we do, looking for stuff about ED when i came across a forum for Peyronie's Disease where they talk about using Trazodone on low dose for ED. Apparently it is an antidepresant with a side affect of Priapism, involuntary erections. The guys in there who have had prostatectomy use it at 25mg low dose for penile therapy, the drug is taken after an evening meal and they talk about getting good nocturnal erections.
I wondered if anyone in here had come across this or was using it and would welcome any comments please
Take care, Bob.
Age 58
Prostate problems since early 40s
Ed since early 40s
April 2007 biopsy & all clear
July 2010 prostate swollen more, psa up to 5.6 August 6.7
September, biopsy again
October 7th diagnosed prostate cancer, Gleason grade 6 at 10% mass
December 13th 2010 open Radical Proctatectomy (non nerve sparing)
Pathology results came back Gleason grade 7 at 12% mass BUT clear margins
Catheter out Jan 5th 2011
Caverject for penile therapy 22nd Jan 2011
Dry at night since 1st Feb 2011

Regular Member

Date Joined Aug 2010
Total Posts : 245
   Posted 3/9/2011 3:27 PM (GMT -7)   
Ahh. This is one of the major reasons I hang around here - looking for people thinking "outside the box" as far as ed is concerned! I, too, had been surfing the net last night and this morning for help for my husband but instead found a physician's blog on a young man with priapism. Unfortunately, it's because his spinal cord was irreversibly damaged in an automobile accident. Your discovery is waaaay better. I hope someone has some observations on trazodone. I'll be checking it out...
Husband 60yrs., no symptms: PSA 10/04 2.73, 12/06 3.64, 5/09 3.9, 10/09 4.6, 1/10 5.0w/ free PSA 24
6 core biop 4/1/10 path rept: rt mid: adnocarc. G=3+3, 5% of core; R apx v. susp. minute ca, R base bnign w/ mod. atrophy, L side atrphy only; 2nd opnion JH confrmd
MRI - 15mm nodule
BiLatRP surg 7/6/10, path: T2c, nodes, sem.ves, extra caps. neg., adenoc both sides G=3+3 cntinent, Viagr-8/27 ED

Regular Member

Date Joined Jan 2010
Total Posts : 363
   Posted 3/9/2011 3:49 PM (GMT -7)   
I think we may have found the same site, I saw that a few weeks ago. I had a 'scrip for Trazadone to help me sleep when first diagnosed. I'm waiting to see my Dr for a refill as it expired not too long after my surgery and I never bothered to get it renewed.

Gotta say I never noticed an increase in nocturnal action when I first got it and of course in the first month post surgery it wasn't an issue.

Keep us posted if you try it.

Dave in Durango CO
07-06 PSA 2.5
01-08 PSA 5.5
09-09 PSA 6.5
12-09 Biopsy, initial Gleason 9 (4+5) later reduced to 8 with tertiary 5
03-01-10 Age 55 RRP in Durango CO by Dr Sejal Quale and Dr Shandra Wilson
03-16-10 Path' G-8 (4+4+5) Bilateral involving 21% of left lobe, 3% of right lobe, SVI, Focal positive margin, pT3b NO MX

All PSA as of 1-25-11 <0.04

Regular Member

Date Joined Jan 2011
Total Posts : 112
   Posted 3/9/2011 4:42 PM (GMT -7)   
I've been taking 75 MG of Trazodone before bed to help me sleep off and on for the better part of 10 years. Here all this time I thought my erections were natural. Anyway, I'm still taking trazodone each night and due to have my catheter removed in 2 days. I'll keep all those concerned of my ED progress updated.
DOB: 01/1961
PSA: 01/2010 2.8
PSA: 11/2010 4.2
DRE: 12/2010 Normal
PSA: 01/2011 4.1
Biopsy: 01/2011 7 out of 12 cores +
Gleason: 6(3+3)
Stage: T1C
Epstein 2nd opinion.
da Vinci 03/04/2011 Penn Hospital

Veteran Member

Date Joined Aug 2009
Total Posts : 2435
   Posted 3/9/2011 5:14 PM (GMT -7)   
I have been taking traz since I accompanied my wife to Houston for her stem cell transplant in May 2006. 14 weeks in a one bedroom apt and I got the worst case of insomnia that I was not able to shake upon return. My doc put me on it and I have been on it ever since.

I have had nocturnals since shortly after my surgery. Maybe it is keeping the blood flowing. At 17 months post surgery I see ever increasing signs that I may have something useable in the near future.

All along the Traz was helping and I thought it was only giving me a good night's sleep.

Yee-Haw, refill the script.


New Member

Date Joined May 2011
Total Posts : 1
   Posted 5/4/2011 7:17 AM (GMT -7)   
I have not had a prostate problem, but my doctor recently prescribed trazodone to replace ambien for sleeping.  A side effect I noticed was more erections at night. Also, levitra is more successful the day after having taken trazodone at night.  I think trazodone is an alternative ED med, or supplement to the others.  Has anyone had similar experiences, and what minimum dosage of trazodone seems to work.  I find it sometimes gives me a headache, and I would like to use it for ED, without the drowsiness. 

Regular Member

Date Joined Jun 2010
Total Posts : 74
   Posted 5/4/2011 8:32 AM (GMT -7)   
This is a (possible) life preserver tossed to a drowning man.  I just made an appointment with my Uro to talk "frankly" about ED now that it's been 18 months post DaVinci.  I've been through the trimix/bimix/hand pumps and the shots just kill me (pain/twisting/hour after hour).  Cialis is not effective and Viagra gave me the "blue light" effect.  Now, at least, I have something to talk about with the URO.
Age at Dx: 56
DaVinci Prostatectomy: 10/28/09

Stage: T2C

Gleason - 3+4 = 7

Prosate: 52 grams

Incontinence - absolutely at first, better with time and kegels

ED - Indeed

Regular Member

Date Joined Sep 2010
Total Posts : 27
   Posted 5/13/2011 6:05 PM (GMT -7)   
Hello English,
I have been taking Trazadone since 1998,  I had a prostectomy last year and have not seen, nor felt a rise since my surgery (day or night).  I think that, like most prescriptions, they work differently for every one.  I take 50 mg per night, and as with others I take it so that I can sleep.  But if it works for some that is great.  I would be careful about adding more meds to your life.  Body chemistry is very touchy sometimes.  As for ED I have been given a script for Cialis, and have purchased a pump.  Pump first then maybe the meds.
Wishing you well... wink

Age: 58 Married 28 Years.
Initial PSA 2.9 elevated to 5.7 before Robotic RP surgery
33% of 1 of 12 biopsy points (left side near bladder)
August 9th Prostectomy with 3D Robotic Surgery
August 16 Staples and cath removed.
October 26 cystoscopy to remove blockage
PSA <0.1 November 17, 2010
PSA <0.1 April 2011
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