Staging T3a Guys Out There?

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Skate
Regular Member


Date Joined Oct 2010
Total Posts : 424
   Posted 3/12/2011 12:47 PM (GMT -6)   
Good Morning All!
 
Just concerned about my pathology of T3a staging.  I have thought since surgery that this was not as serious as I now believe it is.  After failed RT and now with 4 months of HT under my belt,  although my T level and PSA are under control at the moment, I am not nearly as optimistic as I once was.  Any T3a opinions out there that offer some further hope?
 
Jack 
Age 59 at Diagnosis 62 now
01/08 PSA 4.17 DRE showed node
03/08 RP - pT3a 10% ca / Nerve Sparing, margins clear, no invasion
Continent 3 weeks post surgery / ED
06/08 until 08/09 PSA 0.01
08/09 PSA .14
09/09 SRT / 36 treatments
01/10 PSA .13
08/11/10 PSA 3.44 T = 25.0
30/11/10 Zoladex ADT
24/02/11 PSA <.04 T = 1.0

compiler
Veteran Member


Date Joined Nov 2009
Total Posts : 7270
   Posted 3/12/2011 12:58 PM (GMT -6)   
Jack:
 
I am having a hard time reading your dates.Am I correct that Jan 2010 your  PSA after SRT was 0.13 and then your NEXT PSA was in AUGUST of that same year and it spiked to 3.44. At that time you got a baseline T and it was 25? (On the low side?). You then started zoladex 3 1/2 months later? Why did you wait? Did you get another PSA in that interim?
 
Also, I get confused. Is zoladex, lupron, and eligard basically the same thing?
 
Also, were you on casodex at all to prevent a flare?
 
Mel

Fairwind
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Date Joined Jul 2010
Total Posts : 3893
   Posted 3/12/2011 1:01 PM (GMT -6)   
Gleason score?

Skate
Regular Member


Date Joined Oct 2010
Total Posts : 424
   Posted 3/12/2011 1:11 PM (GMT -6)   

Mel:

After RT my PSA hovered at .13 / .14 from January 2010 until August 2010 when we watched carefully about every month or less as PSA began doubling quite rapidly so that by November PSA check it was 3.44 and T level was 25 ( average range as per units of measure in Canada) taken as a baseline as we knew where we were headed.  Started Casodex right away in November for flare two weeks prior to first injection of Zoladex (like lupron) and two weeks later. HT has worked like a charm so far.

Jack


Skate
Regular Member


Date Joined Oct 2010
Total Posts : 424
   Posted 3/12/2011 1:16 PM (GMT -6)   
Pathology 3 / 4 G7

compiler
Veteran Member


Date Joined Nov 2009
Total Posts : 7270
   Posted 3/12/2011 1:24 PM (GMT -6)   

Jack:

Ah, that clarifies things. Can you elaborate on the SE?

 

Also, does anyone know the difference between lupron, eligard, and zoladex? Do the SE differ?

Glad the HT is working for you. I suppose you have no idea how long it will work? (Hopefully, many years)

 

Mel

 

 


Skate
Regular Member


Date Joined Oct 2010
Total Posts : 424
   Posted 3/12/2011 1:31 PM (GMT -6)   
My side effects include some weight gain  and some muscle loss which I fight regularly
with exercise and weight lifting.  Other than loss of labido I feel great but do tire a bit.

ralfinaz
Veteran Member


Date Joined Jan 2011
Total Posts : 735
   Posted 3/12/2011 1:35 PM (GMT -6)   
Hi Jack,
Your response to ADT2 has been excellent. Since you had PSA recurrence after RP + SRT there is some residual disease present. Your response to androgen deprivation is an indication that much of the residual disease is androgen dependent. Your testosterone is slightly higher than optimum (best is at 0.69 nmol/L).

At this point in time all is well and you have the potential to go intermittent on androgen deprivation. You might consider adding a 5-alpha reductase to your present protocol to inhibit DHT synthesis. Stay positive, you can do well for many years.

Best,

RalphV
Phoenix, Arizona
Surviving prostate cancer since 1992. RP; Orchiectomy;
GS (4 + 2); bilateral seminal vesicle invasion; tumor attached to rectal wall. Last PSA September, 2010: <0.1 ng/ml
Laughter is the best medicine!

Skate
Regular Member


Date Joined Oct 2010
Total Posts : 424
   Posted 3/12/2011 1:40 PM (GMT -6)   

Ralph:

Would you say that T level of 1.0 is evidence that the HT is starting to do it's job at only three months out?  Hoping for a further reductions next PSA / T in May.

J


F8
Veteran Member


Date Joined Feb 2010
Total Posts : 3998
   Posted 3/12/2011 1:52 PM (GMT -6)   
Jack -- keep in mind that the HT will work on your head.  my last shot was the toughest for feeling weepy and unsure but those feelings passed pretty quickly. 
 
ed
 
 
age: 55
PSA on 12/09: 6.8
gleason 3+4 = 7
HT, BT and IGRT
received 3rd and last lupron shot 9/14/10
2/8/11 PSA <.1, T= 6 ng/dl

Skate
Regular Member


Date Joined Oct 2010
Total Posts : 424
   Posted 3/12/2011 1:55 PM (GMT -6)   

Ed:

Seems that the first few weeks after an injection take a toll.  I found after two months on my first injection,  I actually began to feel normal again, whatever normal is.  Haven't felt the real normal since before my RP three years ago.

J


F8
Veteran Member


Date Joined Feb 2010
Total Posts : 3998
   Posted 3/12/2011 2:02 PM (GMT -6)   
Jack -- normal.  i hear you.  how i feel today is "normal" because it's been this way for so long.  hang in there buddy.
 
ed
 
 
age: 55
PSA on 12/09: 6.8
gleason 3+4 = 7
HT, BT and IGRT
received 3rd and last lupron shot 9/14/10
2/8/11 PSA <.1, T= 6 ng/dl

ralfinaz
Veteran Member


Date Joined Jan 2011
Total Posts : 735
   Posted 3/12/2011 2:38 PM (GMT -6)   
Yes Jack. Although manufacturers of LHRH agonists only claim their products to reduce and maintain serum testosterone to castrate range (≤50 ng/dL)(1.73 nmol/L) some purists claim the optimum level to be 20 ng/dL (0.69 nmol/L).

Your 1 nmol/L is therefore better that the claim for the product. You are responding well!

RalphV
Phoenix, Arizona
Surviving prostate cancer since 1992. RP; Orchiectomy;
GS (4 + 2); bilateral seminal vesicle invasion; tumor attached to rectal wall. Last PSA September, 2010: <0.1 ng/ml
Laughter is the best medicine!

leeanglo
Regular Member


Date Joined Dec 2010
Total Posts : 191
   Posted 3/13/2011 4:38 AM (GMT -6)   
Good morning Skate, I had my second 3 month zoladex shot 2 weeks ago and the hot flushes returned.i Think, in my opinion, that if you have i slow release in your system and that will continue to have effect for i month after the three month period then when we are given another shot we actually have double the amount of chemical in our bodies......hence return to the side effects at there worst ????
anyone else have any veiws...???
psa on dx 144, gleason 4+3 7 12 biopsie cores cancerous
T3a N2 M1.
psa after 3 months zoladex 20
T levels 0.5 after 3 months zoladex.
changing to monotherapy cosadex feb 2011.

Skate
Regular Member


Date Joined Oct 2010
Total Posts : 424
   Posted 3/13/2011 10:13 AM (GMT -6)   

Lee, that could be what happens, although I certainly feel the wearing of in the last month of the injection.  Lee, are you still on Zoladex or have you switched to casodex only?

Jack

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