Lennybob- your comment : Don,
I am sorry for your news. I do not understand this disease. I also do not understand why people react differently to different treatments. None of it makes sense to me. I pray for many people on this forum and I will do the same for you.
The issues are so complex and vast that the current technologies cannot fully define PCa as to which receptors are the problem, some genes can be tested or effected(some still unknown), has 24 variant types of PCa now identified, the DNA of PCa biopsy samples could have different 3 ploidy analysis(chromosomal patterns-best to be found with diploid cell structures). I have posted the evidence of valuable pathology (link herein again), do look at what is in this to get the concept of some of it. Plus, PCa androgen receptors for HT control can change and thus become refractive on the use of HT therapies, but another drug can enter through a different pathway or type of receptor....freakin complex. There are a couple of different pathways to effect the PCa, is the good news, Provenge utilizes one of these genes that Bonkhoff is mentioning (is what I ascertain).
I have had very great success on alternative drug that has been working for 6-7 years, when ADT3 showed signs of failing back in 2004-5, it is apparently working on a different pathway and might even match up well with my genetic disorder for the disease. It has astounded me that it has worked this long and still is. This is why the artistry of Dr. Myers and those other celebrity docs as being worthy, they are doing so even without the known pathology that Bonkhoff could help identify. Probably way better if they knew this predictive pathology up front. Dr.Fred Lee has had super success on his uncureable PCa and now still living and around 28-29 yrs. since his diagnosis, used emcyt too. He is off the drug I have heard from insiders too.
Bonkhoff on pathology: http://www.prostapath.org/download/prognostic-predictive-markers.pdf
(this is a huge clue, and is under utilized, but he is the best in the world on this thus far)
Hope this helps you comprehend the how difficult it is to treat it once one has BCR.
Post Edited (zufus) : 3/16/2011 8:38:52 PM (GMT-6)