hormone therapy with radiation

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duke68
Regular Member


Date Joined Mar 2007
Total Posts : 242
   Posted 3/24/2011 11:14 PM (GMT -6)   
Hi,

Here are results of SRT plus ADT.

http://www.telegraph.co.uk/health/healthnews/8404230/Hormone-therapy-doubles-survival-chances-in-prostate-cancer.html

Best wishesGerry
age 72 diag 68 Oct 2006 G8 T2b psa 11.7
4 of 8 cores 20% 30% 60% 100%
rrp Dec 2006 G9 4+5 m+ sv+ ece after 6 weeks psa 0.6 second opinion Dana-Farber pT3b 4+4 + T5 = G9
3/2007 ADT2 6 months lupron + casodex
4/2007 SRt 35 sessions to lymph nodes and prostrate. Psa <0.1 from June 2007 to March 2010
Psa 6/10 0.3 9/10 0.6 12/10 2.5 :(
Dana- Farber Phase 2 trial Avastin ADT2
3/11 psa 0.02

Fairwind
Veteran Member


Date Joined Jul 2010
Total Posts : 3738
   Posted 3/25/2011 11:46 AM (GMT -6)   
Yes, that is encouraging..The only question remaining is how long to continue the HT...My R-doc wants two years but he is willing to negotiate..
Age 68.
PSA age 55: 3.5, DRE normal.
age 58: 4.5
61: 5.2
64: 7.5, DRE "Abnormal"
65: 8.5, " normal", biopsy, 12 core, negative...
66 9.0 "normal", 2ed biopsy, negative, BPH, Proscar
67 4.5 DRE "normal"
68 7.0 3rd biopsy positive, 4 out of 12, G-6,7, 9
RALP Sept 3 2010, pos margin, one pos vesicle nodes neg. Post Op PSA 0.9 SRT, HT. 2-15-'11 PSA 0.0

ralfinaz
Veteran Member


Date Joined Jan 2011
Total Posts : 735
   Posted 3/25/2011 12:25 PM (GMT -6)   
That is the key issue Fairwind. It is possible that it might be different for different people given the actual hormonal status of the tumor load (androgen-dependent/androgen-independent ratio). Some purists mention a minimum of 9 months, but others cite 12 to 16 months to be on the safe side and induce as much androgen-dependent cell compartment kill as possible. It is probably smart to go intermittent as soon as possible and closely monitor testosterone recovery and PSA.

RalphV
Phoenix, Arizona
Surviving prostate cancer since 1992. RP; Orchiectomy;
GS (4 + 2); bilateral seminal vesicle invasion; tumor attached to rectal wall. Last PSA September, 2010: <0.1 ng/ml
Laughter is the best medicine!

medved
Veteran Member


Date Joined Nov 2009
Total Posts : 1096
   Posted 3/25/2011 1:05 PM (GMT -6)   
One note: The study to which this article refers involved radiation as a primary treatment, rather than salvage radiation. The extent to which the "six month suggestion" applies to salvage radiation is (at least to me) an open question. I suspect it depends in part on the likelihood that the cancer remains contained in the prostate bed.

duke68
Regular Member


Date Joined Mar 2007
Total Posts : 242
   Posted 3/25/2011 2:42 PM (GMT -6)   
Hi,

I was on 6 months ADT2 for SRT. At that time they where questioning whether that was the best time frame especially for high risk.

I'm on 6 months ADT2 for the avastin trial.
They are now thinking that 6 months with testosterone at castrate and PSA undetectable or near undetectable 0.2 to 0.01 that 6 months will give a lengthy remission and slow down the time too androgen independent

So I'm on a trial for avastin, 6 months ADT2, Casodex with Lupron combination.
The effectiveness of casodex phase 2

Best wishes

Fairwind
Veteran Member


Date Joined Jul 2010
Total Posts : 3738
   Posted 3/25/2011 9:55 PM (GMT -6)   
Right...Even today, the battle rages on over what the optimal treatment period is...
Age 68.
PSA age 55: 3.5, DRE normal.
age 58: 4.5
61: 5.2
64: 7.5, DRE "Abnormal"
65: 8.5, " normal", biopsy, 12 core, negative...
66 9.0 "normal", 2ed biopsy, negative, BPH, Proscar
67 4.5 DRE "normal"
68 7.0 3rd biopsy positive, 4 out of 12, G-6,7, 9
RALP Sept 3 2010, pos margin, one pos vesicle nodes neg. Post Op PSA 0.9 SRT, HT. 2-15-'11 PSA 0.0

livinadream
Veteran Member


Date Joined Apr 2008
Total Posts : 1382
   Posted 3/27/2011 6:08 AM (GMT -6)   
These are difficult questions and not sure there will ever be 100% accurate answer. I was on ADT3 for two years and have now been off for nearly two years. My primary treatment was radiation after the failed surgery. In hind sight I do not believe I would change anything. I hated ADT3 and surely do not want to ever do again however the truth is I probably will in the future. If there are any positives to ADT3 is that it works. Nothing like spending a couple years as a girl and then going back to being a man. Ok just a little humor.

peace to all
Dale
I was 45 at diagnosis with PSA of 16.3
http://www.caringbridge.org/visit/dalechildress

My gleason score from prostate was 4+5=9 and from the lymph nodes (3 positive) was 4+4=8
I had 44 IMRT's. Scheduled to have a radical on July 11th, 2007, surgery was aborted when it was discovered it had spread to the lymph nodes.
I was on Lupron, Casodex, and Avodart for two years with my last shot March 2009.
My Oncology hospital is The Cancer Treatment Center of America in Zion IL
PSA July of 2007 was 16.4
PSA May of 2008 was.11
PSA July 24th, 2008 is 0.04
PSA Dec 16th, 2008 is .016
PSA Mar 30th, 2009 is .02
PSA July 28th 2009 is .01
PSA OCt 15th 2009 is .11
PSA Jan 15th 2010 is .13
PSA April 16th of 2010 is .16
PSA July 22nd of 2010 is .71
PSA Sept of 2010 is .71
cancer in 4 of 6 cores
92%
80%
37%
28%
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