HIFU Clinical Trial for Prostate Cancer

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Gleason 6
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Date Joined Mar 2011
Total Posts : 876
   Posted 4/2/2011 11:24 PM (GMT -6)   
Does anyone know anything about HIFU?  Fact or Fantasy?

John T
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Date Joined Nov 2008
Total Posts : 4268
   Posted 4/3/2011 12:31 PM (GMT -6)   
Facts:
The good:
It has been used successfully in Europe and Japan for a number of years. The side affects are generally much superior to surgery. It can be redone a number of times.
The bad:
Studies released from Europe and Japan indicate a very high reoccurrance rate; much higher than surgery or radiation.
The ugly:
The reoccurrance rate seems to increase as time progresses. In all other treatments the reoccurrance rate decreases as time progresses. You will have to travel to Mexico or Bermuda for treatment and pay out of pocket $25,000, because insurance won't cover it.
JT
65 years old, rising psa for 10 years from 4 to 40; 12 biopsies and MRIS all negative. Oct 2009 DXed with G6 <5%. Color Doppler biopsy found 2.5 cm G4+3. Combidex clear. Seeds and IMRT, no side affects and psa .1 at 1.5 years.

John T
Veteran Member


Date Joined Nov 2008
Total Posts : 4268
   Posted 4/3/2011 3:33 PM (GMT -6)   
Look at the link that Galileo just posted. It's the latest data on HIFU; you can make your own call.
65 years old, rising psa for 10 years from 4 to 40; 12 biopsies and MRIS all negative. Oct 2009 DXed with G6 <5%. Color Doppler biopsy found 2.5 cm G4+3. Combidex clear. Seeds and IMRT, no side affects and psa .1 at 1.5 years.

Postop
Regular Member


Date Joined Feb 2010
Total Posts : 385
   Posted 4/3/2011 6:40 PM (GMT -6)   
Good comments. If HIFU is compared to surgery, it seems to have less adverse effects, but it hasn't been proven to be as effective as surgery or radiation. On the other hand, many men who receive HIFU are also candidates for active surveillance. HIFU definitely has more adverse effects than AS; it can cause ED and incontinence. Besides, in the US insurance will pay for AS but not HIFU. HIFU has to be proven to have better long term outcomes that AS for low risk prostate cancer before it should be used for these men. It will take many years of followup to try to prove that.
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