HIFU Treatment Data is Maturing

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Veteran Member

Date Joined Nov 2008
Total Posts : 697
   Posted 4/3/2011 1:25 PM (GMT -6)   
Nathan Roundy, who a few months ago summarized adjuvant and salvage radiation questions and research so well, reviews the most recent data on HIFU in the current issue of PCRI Insights.


Dx Feb 2006, PSA 9 @age 43
RRP Apr 2006 - Gleason 3+4, T2c, NX MX, pos margins
PSA 5/06 <0.1, 8/06 0.2, 12/06 0.6, 1/07 0.7.
Salvage radiation (IMRT) Jan-Mar 2007
PSA 9/2007 and thereafter <0.1

John T
Veteran Member

Date Joined Nov 2008
Total Posts : 4269
   Posted 4/3/2011 3:29 PM (GMT -6)   
Very good researched article. HIFU is not yet ready for prime time looking at the results compared to conventional treatments.
65 years old, rising psa for 10 years from 4 to 40; 12 biopsies and MRIS all negative. Oct 2009 DXed with G6 <5%. Color Doppler biopsy found 2.5 cm G4+3. Combidex clear. Seeds and IMRT, no side affects and psa .1 at 1.5 years.

Elite Member

Date Joined Oct 2008
Total Posts : 25393
   Posted 4/3/2011 3:41 PM (GMT -6)   
Just more reasons than ever not to chance it with HIFU.
Age: 58, 56 dx, PSA: 7/07 5.8, 10/08 16.3
3rd Biopsy: 9/08 7 of 7 Positive, 40-90%, Gleason 4+3
open RP: 11/08, on catheters for 101 days
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos marg
Incont & ED: None
Post Surgery PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, 8/6 .06 2/11 1.24
Latest: 6 Corr Surgeries to Bladder Neck, SP Catheter since 10/1/9, SRT 39 Sess/72 gy ended 11/09, 21 Catheters, Ileal Conduit Surgery 9/10,

New Member

Date Joined May 2011
Total Posts : 4
   Posted 5/19/2011 1:06 AM (GMT -6)   
Hello to Purgatory from Nathan Roundy. I notice your PSA is rising after RRP and salvage radiation. The question is now what?

1. You can compute PSA doubling time here www.mskcc.org/mskcc/applications/nomograms_v2/PSADoublingTime.aspx . It looks like you have fast doubling of 6-7 months and that is cause for concern.

2. Men with high risk diagnosis and fast doubling time have been shown to do better by early initiation of hormone blockade. The latest research seems to show intermittent hormone blockade is just as effective as continuous, with lower cost and side effects.

3. I maintain the patient outcomes database for Dr. Bob Leibowitz where we have a series of men with dangerous disease who are doing very well. Have a look at his paper compassionateoncology.org/pdfs/3-pronged-111908.pdf.

4. Two papers out this year show Proscar and Avodart slow progression in men who are diagnosed; one about men on active surveillance, and one about men who failed local surgery or radiation. That new data should convince more doctors to proscribe Proscar or Avodart.

5. You can read a lot of good papers about rising PSA, hormone therapy and other useful topics at the PCRI Papers web site www.prostate-cancer.org/pcricms/node/16

6. Pomegranate may lengthen doubling time. See the PCRI March 2011 Insights here www.prostate-cancer.org/pcricms/sites/default/files/PDFs/Is14-1.pdf

7. There are lots of options. If you want to discuss them, email me nroundy@pcri.org or call 805 642 2297

added clickable html to links

Post Edited By Moderator (James C.) : 5/19/2011 8:17:12 AM (GMT-6)

Veteran Member

Date Joined Dec 2008
Total Posts : 3149
   Posted 5/19/2011 7:40 AM (GMT -6)   
Nathan- if you go back to your thread links, and using the edit pen at top right corner on the cyber printed page we had written(click on the pen=editting), then in order to make your links a clickable event which is a huge plus. Just place your cursor at the last letter of your link and press space bar and then it lights up into color and is used, easier.
www.hrpca.org   (see lights up in blue or color thereafter)

Post Edited (zufus) : 5/19/2011 7:13:14 AM (GMT-6)

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