reachout - the difference is probably explainable by the nature of the sample. This sample was not entirely low risk patients, it was a mix of patients of different risk levels. They were all PT2, N0, SM-. But some were G4+3=7 and higher. Some had PSA>10. Some may have had other negative features on their pathology such as EPE+, SV+. See below, from the abstract:
The abstract said...
The study included 1,368 consecutive patients with pT2, N0 and surgical margin negative (SM-) CaP treated with extended PLND (ePLND) and RP for clinically localized CaP at a single referral center. All patients underwent an anatomically defined ePLND (including removal of obturator, external iliac and hypogastric nodes). Patients were divided into two groups according to the extent of PLND: <20 and ≥20 lymph nodes removed. Pre-operative as well as pathological variables were available for all patients. BCR at 2, 5 and 8 years after surgery in the overall patient population and in each group was calculated. The association between the extent of PLND and BCR - after accounting for pre-operative PSA and age at surgery, prostate weight and pathological Gleason score - was determined. Overall, mean number of nodes removed was 16.6, and pathological Gleason sum was 6, 3+4 ,4+3 and 8-10 in 56.1, 32.4, 8.4 and 3.1% of patients, respectively. Mean PSA was 7.86 ng/ml and mean prostate weight was 53.2 grams. No patient received any adjuvant treatment.
Post Edited (proscapt) : 4/7/2011 7:54:35 PM (GMT-6)