Just pondering a new thought. In most of my personal research over the past 3 years, its seems like when there is metastasis with advance PC, it usually, but not always, heads straight for bones. In a lot of cases, it starts out in the hip or femur areas, from examples I have seen. Makes sense to some degree, as those bones are closest to the original source of the PC, the prostate.
I am wondering does if have to go to the bone first, then making its way to the nearest organs, in that order? Or with micro-mets, new PC clusters could literally be anywhere in the body. I have herd of PC being on the liver, the lungs, and even the brain.
Not all will agree with this statement, but after gathering the opinions of 5 different doctors over time, PNI is a likely outlet for PC in the first place, allowing an open network of pathways allowing cancer cells to long escape the prostate glad itself, having taken place long before the patient's PC dx was ever made.
Wondering what other factors play into the world of mets and micro-mets. In my particular case, the doctor's thinking (he never stated it as a fact), was that with my rapid post SRT rise now, particularly the past 2 months, that more than likely that there are multiple sites they are adding up to the combined total PSA on my latest reading.
Feel like I am missing something here on the subject, open for input, or if there are any specifics published studies on the subject.
David in SC