statins and BCR

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medved
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Date Joined Nov 2009
Total Posts : 1096
   Posted 4/10/2011 11:10 AM (GMT -6)   
There has been a fair amount written about the apparent benefit of statins in reducing the incidence of prostate cancer and in extending PSADT.  Now this:  http://onlinelibrary.wiley.com/doi/10.1111/j.1464-410X.2011.10159.x/abstract;jsessionid=0439575BEDF54F66C9AC040A2F59F484.d02t02
 
Makes it hard to tell what is good and what is not so good.  I find this notion of "masking" disease to be one of the most confounding issues.  Is what you are doing actually benefitting  you, or just fooling you into a false sense of complacency by "artificially" reducing your psa?
 

daveshan
Regular Member


Date Joined Jan 2010
Total Posts : 363
   Posted 4/10/2011 11:30 AM (GMT -6)   
My Dr put me on statins after my first "0.0" test, I asked about masking and she said it's possible but so far the indications are that it really may slow/stop BCR. I guess as with most things time will tell.

Too bad we're still the lab rats for so much of this disease.
Dave in Durango CO
07-06 PSA 2.5
01-08 PSA 5.5 (Dr never told me)
09-09 PSA 6.5
12-09 Biopsy, initial Gleason 9 (4+5) later reduced to 8 with tertiary 5
03-01-10 Age 55 RRP in Durango CO by Dr Sejal Quale and Dr Shandra Wilson
03-16-10 Path' G-8 (4+4+5) Bilateral involving 21% of left lobe, 3% of right lobe, SVI, Focal positive margin, pT3b NO MX

All PSA as of 1-25-11 <0.04

tatt2man
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Date Joined Jan 2010
Total Posts : 2842
   Posted 4/10/2011 11:35 AM (GMT -6)   
medved-
- it appears the negative aspect is the potential (in the eyes of this one study) that the statins may mask the PSA level resulting in later detection of PCa.
-they still have to do their study regarding statins and post-op PCa ( my situation)
from the internet source said...
CONCLUSIONS

•  Statin users are at an increased risk for BCR following RP. This finding may be due to the reduction in preoperative PSA potentially delaying diagnosis and/or masking aggressive disease.

• Further studies are necessary to elucidate the impact of statin medications following prostate cancer therapy."


- my urologist / surgeon is pleased with my POST-OP PSA of 0.02 and is aware I am taking statins and I have graduated to once a year testing....

.. and another internet source stated-
another internet source said...
Statins And Prostate Cancer Among Men Participating In The Finnish Prostate Cancer Screening Trial

Reviewing PSA levels among statin users screened in the Finnish Prostate Cancer Screening Trial, researchers from Helsinki found a decrease in prostate cancer incidence in this group, compared to those who did not take the drugs. A significant decrease was found in the incidence of T3 cancers and thos with a Gleason score ranging 5-6. Researchers also found lower serum PSA levels and free/total PSA ratios in this population.


-even aspirin can mask PSA levels....
-oh yes, stay away from POM juice if you are on statins !

hugs,
BRONSON
Age:55 -gay with spouse of 14 years, Steve -Peterborough, Ontario, Canada
PSA:10/06/09 3.86
Biopsy:10/16/09- 6 of 12 cancerous samples, Gleason 7 (4+3)
Radical Prostatectomy:11/18/09
Pathology:pT3a -Gleason 7 -extraprostatic extension -perineural invasion -prostate weight -34.1 gm
PSA:04/08/10 -0.05 -Zero Club
PSA:09/23/10 -0.05 -Zero Club
PSA:03/24/11 -0.02 -Zero Club
PSA:03/24/12- TBA

Post Edited (tatt2man) : 4/10/2011 11:43:37 AM (GMT-6)


Newporter
Regular Member


Date Joined Sep 2010
Total Posts : 225
   Posted 4/10/2011 1:27 PM (GMT -6)   
Why stay away from POM juice if on Statin?

proscapt
Veteran Member


Date Joined Aug 2010
Total Posts : 644
   Posted 4/10/2011 1:31 PM (GMT -6)   
I am on statin and have been taking pom juice as well for more than a year with no problems. I asked my GP and my nutritionist (at UCSF) and both said this is myth. THere are no problems with statins and POM. The thing you have to watch out for with statins is if you drink a lot of grapefruit juice. Both grapefruit juice and statins are metabolized by the same pathway in the liver, so if you take both it means the body eliminates the statin more slowly, and so it builds up. It is as if you are taking several times the dose of statins that you think you are taking.
DX age 54 12/2009
PSA 5.6, DRE-, high pre-op PSAV. Clinical stage T1c
Biopsy: Gleason 3+4 with PNI / 6 of 14 cores + / 10% of total length + / worst 45% +
DaVinci RP 2/2010
pT2cNx / Gleason 3+4 / PNI+ / SM- / SV- / EPE- / Tumor vol 3cc / vol 40cc / 63 gm
PSA - 4/10 <0.01, 8/10 0.01, 12/10 0.01, 3/11 0.01

tatt2man
Veteran Member


Date Joined Jan 2010
Total Posts : 2842
   Posted 4/10/2011 3:13 PM (GMT -6)   
PROSCAPT:
I tried to find my previous link to the bad interaction of Lipitor ( a statin) and pomegranate juice - and couldn't find it.....the sites I found today -> the nuts-and-twigs sites ( dated - 2006-7) said pom juice was bad & stated repeatedly: it alleges / supposedly/ similar to grapefruit /no proof yet that but ....

-when I talked to my pharmacist about pom juice and statins, he was not aware of any interaction ....

-one of the sites talked about immediate interaction, and like you, I have been taking it in very moderate doses - 3-6 oz a day with breakfast ( statin taken with food at evening meal)for over a year ....
-and I ain't dead yet ( nor any renal failure)...skull

-and my PSA actually went down smilewinkgrin - see signature below -
-so will go back to it... I actually like the taste.

hugs
BRONSON
Age:55 -gay with spouse of 14 years, Steve -Peterborough, Ontario, Canada
PSA:10/06/09 3.86
Biopsy:10/16/09- 6 of 12 cancerous samples, Gleason 7 (4+3)
Radical Prostatectomy:11/18/09
Pathology:pT3a -Gleason 7 -extraprostatic extension -perineural invasion -prostate weight -34.1 gm
PSA:04/08/10 -0.05 -Zero Club
PSA:09/23/10 -0.05 -Zero Club
PSA:03/24/11 -0.02 -Zero Club
PSA:03/24/12- TBA

Post Edited (tatt2man) : 4/10/2011 3:16:58 PM (GMT-6)


John T
Veteran Member


Date Joined Nov 2008
Total Posts : 4226
   Posted 4/10/2011 6:45 PM (GMT -6)   
It seems that anything you do to lower your cholesterol also seems to help PC.
JT
65 years old, rising psa for 10 years from 4 to 40; 12 biopsies and MRIS all negative. Oct 2009 DXed with G6 <5%. Color Doppler biopsy found 2.5 cm G4+3. Combidex clear. Seeds and IMRT, no side affects and psa .1 at 1.5 years.

compiler
Veteran Member


Date Joined Nov 2009
Total Posts : 7204
   Posted 4/10/2011 8:03 PM (GMT -6)   

Actually, I stopped zocor (too many SE) and I might request Lipitor.

 

Is the verdict that it is a good idea to be on a statin even after dx?

 

Mel


tatt2man
Veteran Member


Date Joined Jan 2010
Total Posts : 2842
   Posted 4/11/2011 4:57 AM (GMT -6)   
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