Study on Mets locations in Prostate Cancer

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Tony Crispino
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Date Joined Dec 2006
Total Posts : 8128
   Posted 4/12/2011 12:07 PM (GMT -6)   
This one flipped by from the PPML. Here is a study in human cadavers that were diagnosed with prostate cancer. It shows the most common locations for metastatic pathways of prostate cancer:


Mets to the different places (percentages add to over 100% because of multiple metastatic sites in study)

Distribution of PCa within the Body Upon Autopsy:

Bone: 90%
Lung: 46%
Liver: 25%
Pleura: 21%
Adrenal Gland: 13%
Brain and Meninges: 7.5%
Peritoneum: 7.0%
Ureter/urethra: 3.4%
Kidney: 3.1%
Pericardium: 2.5%
Spleen: 2.2%
Stomach/Bowel: 1.8%
Thyroid: 1.6%
Pancreas: 1.4%
Mesentery: 1.1%
Others: 8.3%

Hum Pathol. 2000 May;31(5):578-83; Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients; Bubendorf L, Schopfer A, Wagner U, Sauter G, Moch H, Willi N, Gasser TC, Mihatsch MJ.

Thanks to Ron Levin for the post.

Tony
Advanced Prostate Cancer at age 44 (I am 48 now)
pT3b,N0,Mx (original PSA was 19.8) EPE, PM, SVI. Gleason 4+3=7

Treatments:
Da Vinci Surgery ~ 2/16/2007
Adjuvant Radiation Therapy ~ IMRT Completed 8/07
Adjuvant Hormone Therapy ~ 28 months on Casodex and Lupron.
Undetectable PSA.

Blog: www.caringbridge.org/visit/tonycrispino

davidg
Veteran Member


Date Joined Feb 2011
Total Posts : 4093
   Posted 4/12/2011 12:14 PM (GMT -6)   
Reminds me I need to have my liver checked again.

The problem with it spreading to the bones so frequently is that as we age our bones start to deteriorate anyway. I know I found out I had degenerative spine disease right before my surgery when they made sure I was fit for surgery. So of course in y (our ) mind, every little ache and pain automatically becomes cancer spreading.

Carlos
Regular Member


Date Joined Nov 2009
Total Posts : 486
   Posted 4/12/2011 12:27 PM (GMT -6)   
Tony,  What happened to the lymph nodes? 
 
Carlos

Dx 2/2008, age 71, PSA 9.1, G8, T1c
daVinci surgery 5/2008, G8(5+3), pT2c
BCR 2 1/2 yrs after surgery
IMRT, 68.4 Gy, 12/2010 - 2/2011
PSA 0.16 six wks after IMRT

Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 4/12/2011 12:46 PM (GMT -6)   
Carlos,
Interesting question. The only thing I can say is that there is no other way to distant organs and that lymph nodes are assumed to be positive if there are other distant mets. I don't have the paper on this so I will research it and try to find the details.

Tony
Advanced Prostate Cancer at age 44 (I am 48 now)
pT3b,N0,Mx (original PSA was 19.8) EPE, PM, SVI. Gleason 4+3=7

Treatments:
Da Vinci Surgery ~ 2/16/2007
Adjuvant Radiation Therapy ~ IMRT Completed 8/07
Adjuvant Hormone Therapy ~ 28 months on Casodex and Lupron.
Undetectable PSA.

Blog: www.caringbridge.org/visit/tonycrispino

Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 4/12/2011 12:55 PM (GMT -6)   
Well finding the paper was not tough. Here it is:

www.ncbi.nlm.nih.gov/pubmed/10836297

The key word here is Hematogeneous ~ spread through the blood system. It's a pretty safe bet that the lymphatic systems is seeing cells stop by on their way to distant locations.

Tony

Herophilus
Veteran Member


Date Joined Sep 2009
Total Posts : 662
   Posted 4/12/2011 8:07 PM (GMT -6)   

Thanks for the post and links!

Hero

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