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landcrab
Regular Member


Date Joined Feb 2008
Total Posts : 25
   Posted 4/17/2011 3:07 PM (GMT -6)   
After failed rrp and radiation treatment, my psa is now 1.3 doubling time approx 6months.
My doctor has just put me on IHRT Casodex 150mg. with a view to see how my psa is in three months, and perhaps stop for three months ?.

It looks as if this is the last form of treatment that is left to me, and now I must admit I'm growing increasingly worried.

I have tried a dairy and red meat free diet, take pomegranate extract tablets, also take 75mg of aspirin daily along with soya isoflavones tablets daily.

Any advice would be welcome regarding diet and supplements, also how long can I expect the casodex to continue to hold down my psa.
diagnosed pc Nov 2007 after small lump
found during routine examination
gleason 7 (3+4 ) psa 4.6.
Da Vinci Jan 2008.
post op pathology report gleason 7 (4+3)
positive margin right side nerves spared.
no incontinence problems.
psa 3 weeks post op .5
psa three months post op .3
wait and watch possible rt
psa .5 Dec 2009 radiation started 63gry.
Radiation failure psa continued to rise.

compiler
Veteran Member


Date Joined Nov 2009
Total Posts : 7269
   Posted 4/17/2011 4:47 PM (GMT -6)   
Good luck. Let us know how it goes. Are they just doing the casodex?? I thought they do that for 2 weeks and then do a shot of lupron.
 
Mel

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 4/17/2011 6:19 PM (GMT -6)   
Some patients do just casodex or flutamides, started decades ago with Dr. Labrie and Dr. Strum and the founder of Paactusa.org as a matter of fact. Ok so you are on what is called normally High Dose casodex, likely to have little heavier on side effects, can almost guarantee you to watch out for boob enlargement issue...however can be counteracted by either drugs like Femara (etc.) or light duty radiations usually 3 sessions (electron rays can be used instead of more potent rays)..this helps stop boob enlargement. This is a common side effect and especially with casodex in high dose.
The other option is let it happen or later do boob surgery reduction...my friend just did that.

So, much depends on your androgen receptors and how they react, because they can change on their own doings along the way and become refractive to some HT therapies and then doc would hopefully (wisely) switch you to another drug that could work differently. Many different pathways and receptors to influence PCa cells, this is why different drugs can be effective, timing is very important as to best results.

Books to read by Dr. Myers on diet is worthy and things written by Mark Moyad also useful. You could probably go to lower doseage of casodex after 3 months and see how it holds up...maybe test monthly. I found walkin PSA testings for $15, back in my early days of panic I did monthly tests for like over year. Best to you. Look at my stats below just for a kicks.
 
OH- did you say looks like last treatment?????? NO WAY....FIND another doc and opinion. Send doc to this website www.hrpca.org  (proven treatments area) yeah
Dx-2002 total urinary blockage from PCa emergency room, bPsa 46.6,
12/12 biopsies all 80-95% vol., Gleasons found 7,8,9's, scans appeared clear, ADT3 prior to Neutron & Photon radiations, DES since 2004-5.

Post Edited (zufus) : 4/17/2011 5:29:37 PM (GMT-6)


Skate
Regular Member


Date Joined Oct 2010
Total Posts : 424
   Posted 4/17/2011 6:47 PM (GMT -6)   

Looks like we are on the same pathway.

Jack


Age 59 at Dx / 63 now
01/08 PSA 4.17 DRE showed node
03/08 RP - pT3a 10% ca , 2 of 12 / 3+4
Nerve Sparing, Margins clear, no SV invasion
Continent 3 weeks post surgery / ED
06/08 until 08/09 PSA 0.01
08/09 PSA .14
09/09 SRT / 36 treatments
01/10 PSA .13
08/11/10 PSA 3.44 / T = 25.0 nmol/L
30/11/10 Zoladex ADT
24/02/11 PSA <.04 / T = 1.0 nmol/L

leeanglo
Regular Member


Date Joined Dec 2010
Total Posts : 191
   Posted 4/18/2011 5:41 AM (GMT -6)   
Landcrab,starting on cosadex as a monotherapy is, without doubt, NOT your last option !!
The doctors can mix and match all types of androgen blockers and lots of other drugs to the mix.These treatments can keep pc at bay for many years.There are also some trial drugs coming into action such as Abireterone,provenge and one im looking at myself is Ipilimumab (and if you can pronounce that last one your a better man than me lol )You are far from running out of options
                                   Good luck lee.
psa on dx 144, gleason 4+3 7 12 biopsie cores cancerous
T3a N2 M1.
psa after 3 months zoladex 20
T levels 0.5 after 3 months zoladex.
now taking 50mg cosadex daily also.

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 4/19/2011 6:19 AM (GMT -6)   
BUMP- (Maybe Terry or Ralph V., Tony et al), could elaborate on the breast enlargement issues and treatment options for that, Landcrab is new to this concept and needs to hear it from others)  I bumped this because Landcrab new amigo to H.W. is looking around for answers on this, even at another forum...that is why I bumped it up.

Leeanglo- gave you a couple a clues out of many others in options protocols

Post Edited (zufus) : 4/19/2011 5:22:51 AM (GMT-6)


landcrab
Regular Member


Date Joined Feb 2008
Total Posts : 25
   Posted 5/11/2011 2:07 PM (GMT -6)   
Thanks for replies guys it's been three weeks on 150mgcasodex and my first psa test was 0.4. down from 1.3.

Testosterone was 24nmol/l which seems rather high, it was 11 last November.
Side effects so far quite tired in late afternoon, but I can offset this by going for a short run. Sleeping much better, but hard to get out of bed in the mornings.

Apart from that no other noticeable SE. I guess it's too early to come to any conclusions re SE. but I feel the reduction is encouraging.
diagnosed pc Nov 2007 after small lump
found during routine examination
gleason 7 (3+4 ) psa 4.6.
Da Vinci Jan 2008.
post op pathology report gleason 7 (4+3)
positive margin right side nerves spared.
no incontinence problems.
psa 3 weeks post op .5
psa three months post op .3
wait and watch possible rt
psa .5 Dec 2009 radiation started 63gry.
Radiation failure psa continued to rise.

torgeir
Regular Member


Date Joined Apr 2008
Total Posts : 35
   Posted 5/13/2011 2:55 PM (GMT -6)   
Good to see your psa has responded well to treatment, interestingly regarding you T levels casodex does increase testosterone.
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