ED and TriMix injections

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New Member

Date Joined Oct 2010
Total Posts : 1
   Posted 4/20/2011 8:58 PM (GMT -6)   
I had the office visit with the 0.1ml injection to initiate/educate me on the process and had a minimal response (showed some signs of life but nothing resembling an erection). A few days later I tried 0.15 and had a brief erection lasting no longer than a minute or two that was sufficient for sex. Since it didn't last long enough, the next two times I tried 0.2 but had responses closer to the 0.1 office visit than the 0.15 brief erection. I suppose the next step should be to try 0.25 but I can't get over that fact that I had an erection at 0.15.

Has anyone else had similar responses before they found the "right" dosage? Does it matter if one is sexually aroused or using it in more of a clinical sense?

I have been fully ED since the surgery and was on Cialis for a while to no effect and am currently using the pump in between injections.
Age: 49
Diagnosed: May 2011
PSA: 3.4 %Free PSA: 13.8
Gleason: 3+4
4 of 11 samples w/ 5-10% involvement
Radical Prostatectomy Sep 2010
Two post-surgery PSA's: undetectable
Fully continent

Regular Member

Date Joined Feb 2011
Total Posts : 83
   Posted 4/20/2011 9:08 PM (GMT -6)   
I'm using bimix instead of trimix but the doc visit injection of .50 was enough for moderate wood, not really stuffable. I have increased by .10 to arrive at .80 that is really quite good. I'll be trying the double dose bimix next so less volume is required.

So I'd say, experiment by increasing a small bit at a time until you get something useful. Remember, there is no standard dosage as each person is going to respond differently.
Age 54
PSA 5.6
Diagnosed Sept. 2010
Biopsy T2b/c Gleason 7, 4+3
RRP Dec. 2010
Pathology pT3a, Gleason 7, 3+4, 20% PCa Negative margins, lymph nodes and seminal vesicles
No further treatment recommended.
3 month post-op PSA 03/2011 <0.01

Veteran Member

Date Joined Apr 2008
Total Posts : 847
   Posted 4/21/2011 1:01 AM (GMT -6)   
Often recommended here is to apply some constriction at the time of the injection and for a few minutes afterwards. Another technique, since you already have a pump, is to pump up a little beforehand. As always, your mileage may vary.
No symptoms; PSA 5.7; Gleason 4+5=9; cancer in 4/12 cores
Non-nerve-sparing RRP 7 March 2008 age 63
Organ confined, neg margins. Gleason downgrade 4+4=8
Fully continent
Bimix worked well; now using just VED
PSA undetectable at first but now 0.4, doubling time 7 months
No radiation but ADT coming unless I can slow down the rise...

Regular Member

Date Joined Dec 2010
Total Posts : 172
   Posted 4/21/2011 8:59 AM (GMT -6)   
I just started on trimix office injection .25, tried the constriction band and dosgae of .2 with nothing, went up to .3 some what effect not good enough though...so .35 about same and no have done two times at .4 with 100% wood for about an hour then if i wanted to arouse it again I can for the next hour or so.....

So.....just keep going up at small dosages you will find the right dose for you, and keep the sudefed and neosenephron spray close at hand jsut incase of the dreaded 6 hour wood!

Good luck!
age 44 when diagnosed 45 now
RRP 9-28-10
gleason 3+3
pathology report clear
11-1-10 PSA 0.02
3 month 0.00
6 month 0.00
12-1-10 noctural erections, not very strong maybe 20% none prior to Osbon pump use
3-30-11 Trimix 1st injection works GREAT! and more nocturnals and even some spontanious erections plus responding a little bit now to oral meds!!! The trimix really started things going!

New Member

Date Joined Jun 2009
Total Posts : 15
   Posted 4/21/2011 5:31 PM (GMT -6)   
Sounds like you're on the right track, starting early with injections & being cautious about the dose. In order to achieve the desired results, I have slowly increased my tri-mix dose to .50 under the doctor's guidance. My results are good, but not perfect, and there is minor variance in the firmness and duration. I agree with the others' advice, practice makes perfect, have the full strength Sudafed on hand just in case.

I'm sure that other factors play a part in the varying results: stress level, stimulation, arousal, frequency, alcohol, fatigue, etc.

My first 2 times were great, then I "missed" the next 2 times, getting only a short, weak result. Now, aiming halfway up, at the 2 O' clock position, with an auto injector, and constricting manually for 4-5 minutes does it. Each successful time increases my confidence & comfort level.
Age 54
Diagnosed December 2005 during physical
PSA .8
Gleason 3 + 3 = 6
12 cores, 2 were positive
RPP(supposedly nerve sparing) April 28, 2006
Catheter out 10 days later
All subsequent PSA's 0

Regular Member

Date Joined Oct 2005
Total Posts : 489
   Posted 4/21/2011 9:34 PM (GMT -6)   

It is a somewhat difficult to advise without knowing the makeup of your particular Trimix mix. What are the PGE-1 (usually 5,10 or 20 mcg/ml) Pap (30 mg?) Phen (1 or 2 mg?) values? Those listed are the usuals. The ordering might be different on the bottle also.

No matter what injection amount used ... having only a brief 1 minute hardening sounds odd -- although others have reported that too.

Other than the amount of injection, sometimes the needle length can make a difference .. some need a full 1/2" needle to hit within the corpus caver .. some a shorter needle to not go all the way thru it!

The danger of upping and upping the dose: if you suddenly hit the right spot you are stuck with the results for hours perhaps.

Also often left and right side injections act a little different -- even with same dose.

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