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dondarrion
New Member


Date Joined Apr 2011
Total Posts : 4
   Posted 4/23/2011 11:24 PM (GMT -6)   
I have been lurking around these groups for awhile. I decided it is time i post my story. I have a difficult case, one of the more aggressive Ive read about.

Here is the background -

My age -48. Current psa 760

Original symptons in early 2008. Difficult urination. Hard to start. Low flow rate.

Went to primary care. PSA = 27. Referred to urologist

Had biopsy. all needles positive. Gleason 9. Cancer out of capsule and into vesicles and nerves.

Had retropubic prostatectomy. Didnt get it all . Margins positive. One node positive, but post op psa undetectable

Started lupron. on it ever since.

Had EBRT of pelvic bed. Thought maybe the cancer was all taken care of.

No sexual function. Manageable incontinence using pads.

Jan 09, psa started rising again.

Tried Casodex, no effect.
Tried abiraterone - placebo trial. No help.
Tried ketoconizole - No effect.

Went for taxotere. lost most body hair, hair on head thinned.

Psa still rose during initial taxotere cycles. Max was around 1200

Stayed on taxotere with one break until psa started rising again. 14 cycles total. Able to get psa below 150 while on taxotere. Stopped taxotere with psa around 650.

Changed to Jevtana. On third cycle currently.

After first Jevtana, psa dropped, it has since started rising again. One more rising psa and will stop Jevtana. Running out of treatment options. May try carboplatin. Hopefully, I can get in a XL 184 trial. Also , I should try abiraterone in case i received placebo the first time.

I have bone mets all over. No organ mets so far. Am on oxycontin for bone pain.

That is my story. Ive been through it all. If you have questions about treatments, please ask....I have probably been through it at some point already.

Casper319
Veteran Member


Date Joined Apr 2011
Total Posts : 771
   Posted 4/23/2011 11:35 PM (GMT -6)   
Sounds like quite a fight your putting up. have you thought about other countries and what drugs they might offer that are not FDA approved.

I wish you the best of luck....my story is only just begun. My PSA and Gleason are similiar to yours....PSA 84 and Gleason 8 and 9.
Age:50 Diagnosed: April 2011, Age 50
PSA Level 84 Gleason: 8 and 9's
Biopsy results: 10 of 12 tested positive for cancer
Bone scan....negative, CT scans...nagative but
possible spread to seminole vesicles but not confirmed. CT scan showed some rough/blurry areas.

Treatment: Surgery (Date/time still unknown)

Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 4/24/2011 1:55 AM (GMT -6)   
Hi Don,
It certainly does look like you have had a long bumpy road. I too am 48 and can count my blessings. But reading your story makes me very humble and also very lucky.

Welcome to HealingWell. There are several here that have been through quite a bit. One in particular you may already know ~ David Emerson. DavidE (FLHW) is his screen name and he is younger than us by a year and his PSA at last glance was over 400 (according to one center).

Thanks for coming. I am certain that there will questions that you can drop in with sage advice.

Tony
Advanced Prostate Cancer at age 44 (I am 48 now)
pT3b,N0,Mx (original PSA was 19.8) EPE, PM, SVI. Gleason 4+3=7

Treatments:
Da Vinci Surgery ~ 2/16/2007
Adjuvant Radiation Therapy ~ IMRT Completed 8/07
Adjuvant Hormone Therapy ~ 28 months on Casodex and Lupron.
Undetectable PSA.

Blog: www.caringbridge.org/visit/tonycrispino

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 4/24/2011 7:49 AM (GMT -6)   
Very sad Don that these therapies are not working well  for you and many patients. I presume you have looked into most things, since you knew about XL-184 a anti-angiogenesis type drug, Swedens version looks like Tasquinimod, and comparitively in like trial phases. Others in that category:  Avastin or bevacizumab

Well all I could mention are ideas to look into:
Abiraterone or Leukine, you can get right now through Dr. Scholz 310-827-770
ARN-509 in trials now, MDV3100 in trials and less potent than ARN-509
DES, emcyt, estradiol patches (might not work at all at this stage)?
Thalidomide (Revlimid), Provenge, Lapatinib

NOVEL Chemicals (mentioned by pathologist Dr. Rubin*:
*Rapamycin-mTOR inhibitor (get with an Rx)
*Celastrol
*Gedunin (from India Tree)
*(clinical trials vaccines or immune stimulants): GM-CSF & anti-CLA4*  (?????)
others targeted ideas, listed by Dr. Rubin:  PSMA(J591), HDAC, valproate, PXD-101 & MGC0103* (???)
(???=in his 2008 Pathology article in Modern Pathology..I have no knowledge on the ??? mentioned items, just throwing out to look into...you could look into such, perhaps).

Perhaps post you journey at: www.yananow.net (many mentors/experiences listed)
 
Glad to see Casper mention looking outside the U.S.A., that is a choice that is seldom mentioned and why not look at anything and everything.

Dx-2002 Mar. total urinary blockage in E-room, bPsa 46.6 12/12 biopsies all 80-95%, Gleasons found 7,8,9's..

Post Edited (zufus) : 4/25/2011 4:41:24 AM (GMT-6)


Herophilus
Veteran Member


Date Joined Sep 2009
Total Posts : 663
   Posted 4/24/2011 8:25 AM (GMT -6)   
Don,
May you find some peace, my best to you.
As TC said I'm Humbled, Thanks for sharing
Hero
Age 51 PSA 6.8
Bxy 10 of 12 Cores positive for Gleason 6. up to 75%
Robotic surg 11-02-09
Post op path. 20% neoplasm;4+3=7 Gleason
All nodes (14) and other related tissue negative for cancer
No EPE
Post op PSA x 3, all <0.01
walkbobwithjack.blogspot.com

clocknut
Veteran Member


Date Joined Sep 2010
Total Posts : 2670
   Posted 4/24/2011 8:57 AM (GMT -6)   
Don, I was in awe as I read your amazing and courageous story.  I'll be thinking of you during the church service this beautiful Easter morning. 

Newporter
Regular Member


Date Joined Sep 2010
Total Posts : 225
   Posted 4/24/2011 9:50 AM (GMT -6)   
Thank you for sharing your courageous story with us. I feel for you and good luck on your fight.

By the way, have you tried Provenge?

Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25380
   Posted 4/24/2011 10:10 AM (GMT -6)   
Don,

What an amazing journey in just 3 years or so. Sounds like you have been through the entire spectrum of PC treatments and curative attempts. I can't say I have ever read a story like yours. You will be a wealth of information here for anyone's treatments or future treatment plans.

I wish my very best to you, as you soldier forward. I admire your stamina and courage thus far, it's truly incredible. Don't be surprised if you end up getting a million of questions based on your experiences.

David in SC
Age: 58, 56 dx, PSA: 7/07 5.8, 10/08 16.3
3rd Biopsy: 9/08 7 of 7 Positive, 40-90%, Gleason 4+3
open RP: 11/08, on catheters for 101 days
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incont & ED: None
Post Surgery PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, 8/6 .06, 2/11 1.24, 4/11 3.81
Latest: 6 Corr Surgeries to Bladder Neck, SP Catheter since 10/1/9, SRT 39 Sess/72 gy ended 11/09, 21 Catheters, Ileal Conduit Surgery 9/10

Skate
Regular Member


Date Joined Oct 2010
Total Posts : 424
   Posted 4/24/2011 10:50 AM (GMT -6)   

Don:

You demonstrate courage, wisdom and a strong will to beat this beast. I commend you. Stay strong.  Our neighbour has been fighting Stage 4 lung cancer for the last 7 years.  She was told it was terminal with 9 months to 2 years at best.   She first told me about HW last November as she attributes her longevity to forums such as this, a strong will and a positive and spiritual lifestyle.  She has good days and bad but she is out and about.  Her motto is to never give up hope.  She has all of the doctors baffled as well as her oncologist.  So... after reading your story and reflecting on my own story of the last 3 years, having gone through failed RP, failed EBRT and presently on HT with success so far, all we really have is the strong will to live and to live with some QOL.  Great going Don and keep up your fight as we are doing as well.

Jack


Age 59 at Dx / 63 now
01/08 PSA 4.17 DRE showed node
03/08 RP - pT3a 10% ca , 2 of 12 / 3+4
Nerve Sparing, Margins clear, no SV invasion
Continent 3 weeks post surgery / ED
06/08 until 08/09 PSA 0.01
08/09 PSA .14
09/09 SRT / 36 treatments
01/10 PSA .13
08/11/10 PSA 3.44 / T = 25.0 nmol/L
30/11/10 Zoladex ADT
24/02/11 PSA <.04 / T = 1.0 nmol/L

leeanglo
Regular Member


Date Joined Dec 2010
Total Posts : 191
   Posted 4/24/2011 11:34 AM (GMT -6)   
HI Don,may i offer you my best wishes.
Im not so far down the road as you are but my stats and situation apears to be very agressive and ive therefore put myself forward for a phase 3 trial for a drug called Ipilimumab (mdx-010) I dont know if youve seen or heard of it but ive done loads of trawling the net and this is one trial that caught my eye.
Good luck.
psa on dx 144, gleason 4+3 7 12 biopsie cores cancerous
T3a N2 M1.
psa after 3 months zoladex 20
T levels 0.5 after 3 months zoladex.
now taking 50mg cosadex daily also.

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 4/24/2011 11:57 AM (GMT -6)   
Lee- I googled this little bit on Ipilimumab:

Mechanism of action Ipilimumab is a fully human antibody that binds to CTLA-4 (cytotoxic T lymphocyte-associated antigen 4), a molecule on cytotoxic T lymphocytes that is believed to play a critical role in regulating natural immune responses.[8] The absence or presence of CTLA-4 can augment or suppress the immune system's T-cell response in fighting disease.[9]

Ipilimumab is designed to block the activity of CTLA-4, thereby sustaining an active immune response in its attack on cancer cells.[10][11][12][13]
-----------------------------------------------------
(This is mentioned by Dr. Rubin in the above list of things I found in his Pathology Journal article, looks like this doc is amongest the wise)
-----------------------------------------------------------------------------
[edit] Clinical trialsAs of October 2007[update], there are two fully human anti CTLA-4[14] monoclonal antibodies in advanced clinical trials. Ipilimumab, which is an IgG1 isotype, and Tremelimumab (from Pfizer) which is an IgG2 isotype.[15][16]

LEE-Do you have some things you could mention about it , since you have looked into it?
DON- and others are reading such and anyone whom is interested can maybe learn something new. Maybe Don has other 'new' to us concepts on PCa, it is surprizing what some people are doing or have done. If you wished to post a longer version of your journey plenty of us would read it, also goto  www.yananow.net  maybe 1000+ patients have their real time PCa journies listed, many with contactable email as mentors. You may be able to help or advise someone else, especially on the protocols and things you know or learned.

Post Edited (zufus) : 4/24/2011 11:05:57 AM (GMT-6)


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25380
   Posted 4/24/2011 2:20 PM (GMT -6)   
Don,

Was re-reading your story again, its a lot to take in at one time. So are you 48 now, or at dx? Looks like your been fighting this thing for 3 years now. You mention 14 cycles of taxotere, how long is each cycle, I don't understand? You mentioned having no detectable PSA after the surgery, how long did it take to start to rise again before you had radiation?

David in SC
Age: 58, 56 dx, PSA: 7/07 5.8, 10/08 16.3
3rd Biopsy: 9/08 7 of 7 Positive, 40-90%, Gleason 4+3
open RP: 11/08, on catheters for 101 days
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incont & ED: None
Post Surgery PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, 8/6 .06, 2/11 1.24, 4/11 3.81
Latest: 6 Corr Surgeries to Bladder Neck, SP Catheter since 10/1/9, SRT 39 Sess/72 gy ended 11/09, 21 Catheters, Ileal Conduit Surgery 9/10

compiler
Veteran Member


Date Joined Nov 2009
Total Posts : 7212
   Posted 4/24/2011 3:52 PM (GMT -6)   
Don:
 
Have you been seeing top doctors? I would think you need someone who is up on the latest drugs/clinical trials. Perhaps a major cancer center is the place to go?
 
Yahoo Groups has a support group for advanced prostate cancer. It would be work posting there, too.
 
Mel

DanielleS
Regular Member


Date Joined Jul 2007
Total Posts : 57
   Posted 4/24/2011 10:24 PM (GMT -6)   
Thank you for sharing your story, Don.  You are a strong fighter in this battle.  My husband was diagnosed in January 2007 at age 53, Gleason 9/10, PSA of 174.  Treatments have included an early trial of Ipilimumab and two plus years on Ketoconazole.   After four Taxotere treaments,  he attempted a trial of oral Cytoxan (Cyclophosphamide) and Revlimid.  The combination caused him severe nausea and he had to halt participation in the trial although it was showing benefit of a PSA drop and shrinkage of a neck lymph node. 
 
One possible option to look into is low-dose Cytoxan.  My husband may pursue this as a single agent -it is an older widely available drug with normally few side effects at the low dose:  http://advancedprostatecancer.net/?p=1620
 
We are also investigating the expanded-access Abiraterone trials. 
 
Good luck,
DanielleS

Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25380
   Posted 4/24/2011 11:22 PM (GMT -6)   
Danielle,

Good luck to your husband, as you continue onward in his journey.

David in SC
Age: 58, 56 dx, PSA: 7/07 5.8, 10/08 16.3
3rd Biopsy: 9/08 7 of 7 Positive, 40-90%, Gleason 4+3
open RP: 11/08, on catheters for 101 days
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incont & ED: None
Post Surgery PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, 8/6 .06, 2/11 1.24, 4/11 3.81
Latest: 6 Corr Surgeries to Bladder Neck, SP Catheter since 10/1/9, SRT 39 Sess/72 gy ended 11/09, 21 Catheters, Ileal Conduit Surgery 9/10

Fairwind
Veteran Member


Date Joined Jul 2010
Total Posts : 3782
   Posted 4/25/2011 12:00 PM (GMT -6)   
Welcome to the forum Don..As you undoubtedly know, we don't see threads like yours very often..There is a small, tight-knit group of Gleason 8 & up guys here who have our own little club inside the general forum. I am one of them..

I always find it amazing that the same affliction, prostate cancer, can be a slow growing Gleason 6 affair that seldom kills but can, at the same time, assume an aggressive, virulent, fast growing, easy spreading monster that usually produces a negative outcome no matter what we do to tame it..We all hold out out hope that tomorrow, they will find something..

I know it took great courage at this time to post your story, but its important that you did, everyone needs to be aware of the dark side of this disease and what can be done to get as much time as we can...Please stay with us and find comfort and support in our group....

Best of luck to you, never give up the ship....
Age 68.
PSA age 55: 3.5, DRE normal.
age 58: 4.5
61: 5.2
64: 7.5, DRE "Abnormal"
65: 8.5, " normal", biopsy, 12 core, negative...
66 9.0 "normal", 2ed biopsy, negative, BPH, Proscar
67 4.5 DRE "normal"
68 7.0 3rd biopsy positive, 4 out of 12, G-6,7, 9
RALP Sept 3 2010, pos margin, one pos vesicle nodes neg. Post Op PSA 0.9 SRT, HT. 2-15-'11 PSA 0.0

dondarrion
New Member


Date Joined Apr 2011
Total Posts : 4
   Posted 4/25/2011 12:03 PM (GMT -6)   
To All -

I have been overwhelmed by the response to my story. I was feeling a bit depressed Saturday night and so decided to try and put down my history - thus my first post. Your responses sure cheered me up. Thanks especially for some of the new therapy options. Regarding some of your questions:

I am seeing a world class PCA dr at a world class uralogical cancer facility. I am shy and wish to remain anonymous for now so I'm not going to name the Dr or location at this point.

Regarding my diagnosis.....I had just turned 45 years old and had my biopsy in March of 08. The biopsy indicated spread of the cancer out of the capsule into the seminal vesicles and surrounding areas. I had the retropubic prostatectomy in May of 08.
The path staging of the tumor at the time = PT3b N1 Mx R1 (Margins Positive, Lymph Node Positive) indicating local metastasis but not distant metastasis. bone and ct scans negative at this time.

The prostatectomy operation was a nightmare and I nearly didnt make it out of the hospital. I will leave that story for another time.

After receiving EBRT from Aug to October 2008, psa was 0.1 (not quite undetectable as I said earlier.)

In Feb 09, psa jumped to .6, and in March 1.3. At that point bone scans showed distant metastasis to bones. At that point I knew the cancer was not killed by the Op or the radiation and was now stage 4 and that my days were probably numbered.

Each taxotere cycle is 3 weeks. Typically, I would give a blood test on Friday, see the oncologist Monday AM and receive the psa result, and receive the infusion of Taxotere in the afternoon. 1 hour infusion of taxotere preceded by a 30 min decadron infusion and a 15 min Zometa infusion (for bone health).

Jevtana is similar to taxotere, but comes with a little more fatigue, and a little more nausea.

Later, I will describe more about:

The prostatectomy - Some things they may not tell you up front. (In the words of George Constanza - "Shrinkage.")

Radiation therapy for male breast growth.

More on Lupron, hot flashes, etc.

Chemo side effects.

Bone mets - A major issue in my life right now.

Regards !

compiler
Veteran Member


Date Joined Nov 2009
Total Posts : 7212
   Posted 4/25/2011 12:43 PM (GMT -6)   
Don:
 
Please keep posting. It sounds like we can learn a lot from your experiences.
 
Mel

richard0460
Regular Member


Date Joined Feb 2011
Total Posts : 49
   Posted 4/26/2011 12:31 AM (GMT -6)   
Don
You have really been through it. I want to echo one of the other writers. Have you seen the best prostate cancer oncologists. Some of them will do phone consults. This is really the time to be talking to the best. Out here in California its Snuffy Myers, Scholz and Stephen Strum in Oregon. Sloan Kettering is the best institution I know of on the East Coast.
Best wishes and prayers in your fight.
Richard
Gl 7 3+4 (30%) 3 of 7 cores Sept 10 (Bahn), Endorectal MRI negative for ECE's, Sem Ves Involvement Nov 10, ADT (Strum) 4 months PSA after ADT .04 Prostate volume fell from 48 cc to 19 cc. Pal 103 Seeds (Grimm) March 30, 2011

GBINAB
Regular Member


Date Joined Apr 2008
Total Posts : 206
   Posted 4/26/2011 3:23 AM (GMT -6)   
Don
welcome and we all appreciate you sharing your experience with us
i have been away from this forum for a while now
i am out of Surgery 4 years already but keep coming to check on the new members of this wonderful forum
i hope this and us will give you the power and force to fight the horrible disease you are fighting
God Bless YOU!!!
April 2007 PSA 8.4 for last 6 months biopsy shows PC 3+3=6
June 13 2007 Nerve Sparing open RP / Dr. Christopher Johnson at St. Francis Hospital NY.
4 days later home for Fathers Day, and W/Catheter.
Incontinence not an issue, no pads used from the get go.
ED is a longer battle:
ED 6 months mark starting with VED therapy and being more aggressive with meds.
April 2008 : 10 month out and start seeing some serious improvements with ED while using Meds and VED , can achieve erections, Mid nights erections more often.
1 YEAR FOLLOW UP
ED: With Viagra Usable erection for intercourse ,
PSA one year : 0.0 as of 6/13/ 2008 BIG Wooohoooooooooo!!!!
UPDATE AS OF Dec 2008 (18 months out)
PSA still at 0!!!
ED with oral meds and the right woman = good sex
At 24 months mark almost fully potent with 50MG Viagra!!!!

Ed C. (Old67)
Veteran Member


Date Joined Jan 2009
Total Posts : 2458
   Posted 4/26/2011 10:10 AM (GMT -6)   
Don,
Thanks for sharing your journey with us. It is quite a story to say the least. Your courage and determination to fight this disease is amazing. I wish you the best. Please keep us posted.
Age: 67 at Dx on 12/30/08 PSA 3.8
2 cores out of 12 were positive Gleason (4+4)
Davinci surgery 2/9/09 Gleason 4+4 EPE,
Margins clear, nerve bundles removed
Prostate weighed 57 grams 10-20% involved
all PSA tests since (2, 5, 8, 11, 15, 18, 21, 2 years <.008? ) undetectable
27 months: .005

dondarrion
New Member


Date Joined Apr 2011
Total Posts : 4
   Posted 4/26/2011 11:53 AM (GMT -6)   
As my psa is rising on Jevtana, I go for a set of bone and CT scans this week. Amazingly, this will be like my 8th set of scans since 2008. For those familiar with bone scans, typically you will see some radio-indicator in the kidneys on the images of the scan. With me, on my last two scans, because of the large amount of bone mets, all the indicator is taken up by affected bones and none makes it to the kidneys. They cant increase the amount of indicator as that is against procedure. This phenomenon is known as "superscan" and has causes the results to be interpreted a little different than a typical bone scan.

Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25380
   Posted 4/26/2011 11:56 AM (GMT -6)   
Don,

What were some of your side effects when you were on taxotere? Aside from hair loss. You said each one was 3 weeks apart, and you had 14 rounds, so that means you were on it for a full year? Yet your PSA continued to rise. How often was your PSA checked during that time period, monthly perhaps?

David in SC
Age: 58, 56 dx, PSA: 7/07 5.8, 10/08 16.3
3rd Biopsy: 9/08 7 of 7 Positive, 40-90%, Gleason 4+3
open RP: 11/08, on catheters for 101 days
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incont & ED: None
Post Surgery PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, 8/6 .06, 2/11 1.24, 4/11 3.81
Latest: 6 Corr Surgeries to Bladder Neck, SP Catheter since 10/1/9, SRT 39 Sess/72 gy ended 11/09, 21 Catheters, Ileal Conduit Surgery 9/10

Sancarlos
Regular Member


Date Joined Feb 2010
Total Posts : 242
   Posted 4/26/2011 12:24 PM (GMT -6)   
Don,

I am very sorry to hear about your struggle with this disease, especially the pain. My heart goes out to you.

You are quite a fighter. Don't stop or give up hope as miracles do happen.

Sancarlos
Age 66, PC diagnosed 7/2009 at age 65
Stage: T2c, Gleason: 9 (4 + 5), 6 of 6 cores positive
Bone, CAT and MIR scans negative

Treatment: brachytherapy (103 palladium), 100 gy, 11/2009 + IMRT on Novalis, 45 gy, 3/2010 + ADT3 (Lupron + Casodex+Avodart)

PSA: 7/2009, At time of diagnosis -- 11.9
10/2009 -- 5.0 ; 12/2009 -- 0.56 ; 5/2010 -- 0.15
8/9/2010 -- 0.06 ; 11/2010 -- 0.013; 3/25/2011-- 0.005

leeanglo
Regular Member


Date Joined Dec 2010
Total Posts : 191
   Posted 4/26/2011 3:16 PM (GMT -6)   
Fao zufus
In response to your thread,I yet have only limited knowledge of the trial drug ipilimumab but read an article in the uk guardian newspaper stating great results in early phase 1 and 2 trials.the reason ive put myself forward is because I can remain on my present ADt treatment at the same time as participating in the phase 3 trial (if I'm accepted).I have a meeting with my urologist on may 17th where I will discuss going into the trial.I believe the trial is recruiting until 2012.
Don my appologies for butting in but this may have been of some use to you.
Don I would also like to say,and I think I can speak for all of us at HW,that you are amongst a group of caring friends.
Regards Lee.
psa on dx 144, gleason 4+3 7 12 biopsie cores cancerous
T3a N2 M1.
psa after 3 months zoladex 20
T levels 0.5 after 3 months zoladex.
now taking 50mg cosadex daily also.
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