Looking for Opinions regarding high PSA biobsy etc.

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New Member

Date Joined Apr 2011
Total Posts : 1
   Posted 4/26/2011 7:49 AM (GMT -6)   
I am a 63 year old man in good health. I exercise daily using a combination of walking, biking yoga and light weights. I eat a very health diet and people tell me I look as if I am years younger, Dr's have said the same. I am of average weight. I started monitoring my psa years ago and it has slowly risen over time. My prostate is swollen and I urinate slowly particularly at night. I have been taking a saw pawmento complex for years. Dr's have not felt anything abnormal besides the swelling on palpation. I have an active sex life which I enjoy.

Recent PSa
03/29/2011 Total 17.2 NG/ML no free done **
02/20/2006 Total 12.5 MG/ML Free 2.10 % Free PSA 17% lab results state about 20% chance of cancer*
9/21/2010 Total 13.3NG/ML Free 3.23 NG/ML % free 24% lab results state about 16% chance of cancer*

*Test Performed by: Beckman/Coulter access Chemilumineescent Assay
**Test performed by: Siemens Centaur Chemi luminescent Assay

I had a biopsy of the prostate in June of 2005
12 samples were taken
3 sites showed Benign prostate Tissue
2 sites showed Benign prostate tissue, with rare involuted glands
1 site showed Benign prostate tissue, showing focal involutional change
2 sites showed Benign prostate tissue showing prominent involutional change
1 site showed benign chronically inflamed prostate tissue
1 site showed benign prostate & hypertrophied stroma
1 site showed benign prostate & stromal tissue
1 site showed Focal high-grade prostatic intraepithelial neoplasia (HGPIN)

As a result of the recent psa total 17.2 NG/ML my Urologist is recommending another biopsies with 18 samples taken. He also stated that there is about a 35% chance that I have cancer but if it comes up negative he wants to put me on Avodent administered once a week.

I am wondering what if any of you would offer any suggestions or advice, I thank you in advance for you assistance.

Veteran Member

Date Joined Jan 2010
Total Posts : 1011
   Posted 4/26/2011 7:52 AM (GMT -6)   
PCa is not some that you want to take lightly. With a 17.2 PSA and the HGPIN in 2005, I would take your drs recommendation and have the biopsy.
Dx PCa Dec 2008 at 56, PSA 3.4
Biopsy: T1c, Geason 7 (3+4) - 8 cores, 4 positive, 30% of all 4 cores.
Robotic RP March 2009
Pathology Report: T2c, Geason 8, organ confined, negitive margins, lymph nodes - tumor volume 9%, nerves spared, no negitive side effects.
PSA's < .01, .01, .07, .28, .50. ADT 3 5/10. IMRT 7/10.
PSA's post HT .01, < .01

Steve n Dallas
Veteran Member

Date Joined Mar 2008
Total Posts : 4829
   Posted 4/26/2011 9:55 AM (GMT -6)   

Welcome to the site and sorry you have to be here..

I agree that another biopsy would be a good thing at this point.

Elite Member

Date Joined Oct 2008
Total Posts : 25380
   Posted 4/26/2011 10:53 AM (GMT -6)   
Hello and welcome Jim,

I fully agree with the others, and would undergo a more extensive biopsy. The prescense of HGPIN before, can be a precursor to turning into cancer cells. This is what happened with me, and it took 3 biopsies to confirm the cancer.

Good luck and please keep us posted

david in sc
Age: 58, 56 dx, PSA: 7/07 5.8, 10/08 16.3
3rd Biopsy: 9/08 7 of 7 Positive, 40-90%, Gleason 4+3
open RP: 11/08, on catheters for 101 days
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incont & ED: None
Post Surgery PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, 8/6 .06, 2/11 1.24, 4/11 3.81
Latest: 6 Corr Surgeries to Bladder Neck, SP Catheter since 10/1/9, SRT 39 Sess/72 gy ended 11/09, 21 Catheters, Ileal Conduit Surgery 9/10

Regular Member

Date Joined Sep 2010
Total Posts : 225
   Posted 4/26/2011 12:04 PM (GMT -6)   
My situation:

2000: PSA=2+

2002: PSA= 4+, biopsy negative

Another negative biopsy in between.

2009: PSA=8.4, biopsy=some atypia (PIN), urologist said 40% chance PC, wanted another biopsy. I decided to wait a year

2010: PSA=10.7, biopsy=cancer+inflammation+atypia(PIN). chose robotic surgery, pathology: worst than what biopsy indicated.

In all cases, urologist started me with antibiotics (did not reduce PSA) then biopsy.

My opinion:

You should seek additional diagnostic/treatment options.
65 Dx June-2010 PSA: 10.7, biopsy: Adenocarcinoma, 1 core Gleason 6, 3 cores atypia; Clinical stage T2; CT, Bone Scan, MRI all negative

8-23-10 Robotic RP; Pathology: Organ confined, negative margins, Lymph nodes, Seminal Vesicle clear; PNI present; multiple Adenocarcinoma sites Gleason 3+3 with tertiary Gleason 4+. Stage: pT2,N0,Mx,R0

Catheter out 8-30-10 no incontinence, no ED. 3/2011 PSA: <.1
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