Journal Cancer (2011)--Factors for Failure after Prostatectomy

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AJ 47 (Maryland)
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Date Joined Aug 2010
Total Posts : 64
   Posted 4/27/2011 6:25 AM (GMT -6)   
This article published just a month or more ago in the Journal Cancer is perhaps the most comprehensive to date on the subject of adjuvant radiation treament (before a PSA rise post RP).  The writers do a very good job at considering much of the data compiled from other well known sources and studies and trying to identify those who might benefit from ART.  Bottom line--high risk Gleason 8-10 and/or those with margins and/or EPE have rates of biochemical recurrence that support adjuvant treatment.  The article contains statistical information from most of the recognized studies from Hopkins, Kattan, Han, Stephenson, Cheng, D'Amico and many others and those statistics are interesting in understanding the number of patients each of was based on (sometimes very few).  It also contains a great bibliography on other related subjects.  Here is the link.
PSA 1.5 to 3.2 in 11 months. First 12 core biopsy on 2/10 negative in 11, atypical in 1. Second 13 core biopsy on 5/10 at Hopkins positive in 2 with Gleason 3+3 (focal). Robotic "Super VIP" Mani Menon 8/10. Postop G 3+4 (70%/30%). Focal ECE right posteriolateral mid. Neg. margins, lymphs, SV. Post op PSAs 9/14 <.1; 1/11 <.1; 4/11 <.1.
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