I keep reading about
Provenge and the more recent drug approvals. Everybody is just thrilled and they are considered major breakthroughs.
Now, I can understand Provenge being considered a breakthrough in the sense that maybe this is a new and better way to treat cancers so that down the road real cures/remissions using these ideas will be found.
But, when I read some of the articles, we find that new tx. did better than old tx. yyy. But the median is 14.5 months compared to 10 months. Okay, I realize that's a median. Half of the people do better for longer. But, that's incomplete information. HOW MUCH LONGER? Are we talking the REASONABLE possibility of an additional year? Then I read about the horrendous SE of many of these drugs. Even provenge has a whole new group of SE in the auto-immune arena.
I really do want to get excited and jump up and down, because there is a high probability that these drugs are in my future (heck, for anyone who fails SRT, we KNOW these drugs are probably in your future). I'm personally hoping I can stave off this beast long enough for some real good drug developments. But, why am I not as excited as it appears I should be.
PSA-- 3/08--2.90; 8/09--4.01; 11/09--4.19 (PSAf: 24%), PCA3 =75 .Biopsy 11/30/09. Gleason 4+3. Age: 64. Surgery: Dr. Menon @Ford Hospital, 1/26/10. Pathology Report: G 4+3. Nodes: Clear. PNI: yes. SVI: No. EPE: yes. Pos. Margin: Yes-- focal-- 1 spot .5mm. 100% continent by 3/10. ED- yes.. PSA on 3/10/10-: 0.01. PSA on 6/21/10--0.02. 9/21/10--0.06; 1/4/11-0.13,3/1/11--0.27. Now doing SRT