Want To begin ADT Vacation Early??

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Skate
Regular Member


Date Joined Oct 2010
Total Posts : 424
   Posted 5/1/2011 3:00 PM (GMT -6)   
Hello All.  I have been on HT (Zoladex) for going on 6 months now.  My first three month blood test back February on HT was: PSA < 0.04 and T level of 1.0.  My Dr. was surprised that I responded so well, so soon.  I am due for my next test for PSA and T level next week.  When I see my Dr. later in May for my third injection, I want to request an HT break now rather than at the end of the year as originally planned.  I will request this only if my results are the same or better.  My wife is flipping out at this as she feels that I am being foolish. After more than three years of treatments, I just want to take a break and try to resume a sense of feeling normal. I want my strength and muscle mass back to what it was without the daily fight to try to maintain them.  I am a fitnesss nut but it's getting more and more difficult.  I want my energy back and I want my T levels like they were.  When that happens or shows signs of happening, I'll be back quick as a flash on HT.  No options there.  Am I rushing this or am I being sensible in trying for an HT vacation?  That last 6 months have certainly been a trip.  Appreciate some wisdom here.
 
Jack

Age 59 at Dx / 63 now
01/08 PSA 4.17 DRE showed node
03/08 RP - pT3a 10% ca , 2 of 12 / 3+4
Nerve Sparing, Margins clear, no SV invasion
Continent 3 weeks post surgery / ED
06/08 until 08/09 PSA 0.01
08/09 PSA .14
09/09 SRT / 36 treatments
01/10 PSA .13
08/11/10 PSA 3.44 / T = 25.0 nmol/L
30/11/10 Zoladex ADT
24/02/11 PSA <.04 / T = 1.0 nmol/L

Fairwind
Veteran Member


Date Joined Jul 2010
Total Posts : 3887
   Posted 5/1/2011 3:19 PM (GMT -6)   
You might find this blog informative..

myprostatedoc.blogspot.com/
Age 68.
PSA age 55: 3.5, DRE normal.
age 58: 4.5
61: 5.2
64: 7.5, DRE "Abnormal"
65: 8.5, " normal", biopsy, 12 core, negative...
66 9.0 "normal", 2ed biopsy, negative, BPH, Proscar
67 4.5 DRE "normal"
68 7.0 3rd biopsy positive, 4 out of 12, G-6,7, 9
RALP Sept 3 2010, pos margin, one pos vesicle nodes neg. Post Op PSA 0.9 SRT, HT. 2-15-'11 PSA 0.0

Skate
Regular Member


Date Joined Oct 2010
Total Posts : 424
   Posted 5/1/2011 4:20 PM (GMT -6)   

Thank you Fairwind.  I found that very informative in addition to the risks I already understand are associated with HT.  For me it is beyond the risks as I'm just tired of doing this treatment course and want a break.  Thanks for help on making a decision.

Jack


Fairwind
Veteran Member


Date Joined Jul 2010
Total Posts : 3887
   Posted 5/1/2011 7:32 PM (GMT -6)   
I understand where you are coming from Skate.. I don't know how far down the HT road I'm willing to go either..We are all men and we want to feel like men and act like men...These oncologists need to recognize that...The risk / benefit ratio needs to be carefully reviewed...

F8
Veteran Member


Date Joined Feb 2010
Total Posts : 3984
   Posted 5/1/2011 7:43 PM (GMT -6)   
Skate -- i got my last shot of lupron on sept 14, three-month variety.  my strength has been improving dramatically in the past three weeks or so.  i'm probably 95% as strong as i was before lupron. sexual desire and function have returned too.  my stamina has improved but not anywhere near where i want it and i can easily sleep an extra two hours a day.  i'll have my PSA and testosterone checked in another month.
 
ed
 
 
age: 56
PSA on 12/09: 6.8
gleason 3+4 = 7
HT, BT and IGRT
received 3rd and last lupron shot 9/14/10
2/8/11 PSA <.1, T= 6 ng/dl

Skate
Regular Member


Date Joined Oct 2010
Total Posts : 424
   Posted 5/1/2011 8:07 PM (GMT -6)   

How long were you on Lupron Ed?  Do you think 6 months is enough to start my first break? Sorry, I re-read and was it 9 months?  Why did you stop when you did?

J


Post Edited (Skate) : 5/1/2011 7:17:53 PM (GMT-6)


F8
Veteran Member


Date Joined Feb 2010
Total Posts : 3984
   Posted 5/1/2011 8:58 PM (GMT -6)   
Skate -- my treatment plan was for 6 months of lupron.  they only wanted me free of testosterone while the radiation was doing its thing.  my doctor decided on the third shot because of the way my scheduling went down.  i wasn't happy about it but his reasoning made sense.
 
your case is different than mine so i would probably side with the doctor.  good luck to you.  i know how you feel.
 
ed
 
  
age: 56
PSA on 12/09: 6.8
gleason 3+4 = 7
HT, BT and IGRT
received 3rd and last lupron shot 9/14/10
2/8/11 PSA <.1, T= 6 ng/dl

Skate
Regular Member


Date Joined Oct 2010
Total Posts : 424
   Posted 5/1/2011 9:14 PM (GMT -6)   
Thank you!

ralfinaz
Veteran Member


Date Joined Jan 2011
Total Posts : 735
   Posted 5/2/2011 11:21 AM (GMT -6)   
Hi Jack,
The decision to stop HT is very personal and depends on the patient’s disease stage after treatment. In your case, you report afterv RP and SRT a PSA recurrence and then a good response to HT. Stopping HT to improve QOL is an important decision and if you closely monitor PSA and testosterone, the risk should be minimal in case your PSA increases rapidly with a testosterone rebound. Just be sure to monitor PSA closely and hopefully you will get a long remission without progression. Wish you the very best results.
Phoenix, Arizona
Surviving prostate cancer since 1992. RP; Orchiectomy;
GS (4 + 2); bilateral seminal vesicle invasion; tumor attached to rectal wall. Last PSA September, 2010: <0.1 ng/ml
Laughter is the best medicine!
www.pcainaz.org/phpBB304

Skate
Regular Member


Date Joined Oct 2010
Total Posts : 424
   Posted 5/2/2011 12:51 PM (GMT -6)   

Thanks Ralfinaz.  Yes it is a personal decision, but I also don't want to go getting stupid about this decision either. I have been e-mail chatting back and forth this morning with my uro oncol. and he'll respect whatever I decide with close monitoring but he is encouraging at least one more injection first. Thanks for your honest reply.

Jack


Casey59
Veteran Member


Date Joined Sep 2009
Total Posts : 3172
   Posted 5/2/2011 1:08 PM (GMT -6)   
Jack, I just wanted to send you a quick note of my support.
Hang in there.
best wishes...

Skate
Regular Member


Date Joined Oct 2010
Total Posts : 424
   Posted 5/2/2011 1:15 PM (GMT -6)   

Thanks Casey. Good to hear from you!  I haven't posted but my thoughts have been with you and what you both are experiencing.  Take good care of each other through everything the future brings as I know you will.

J


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 5/2/2011 1:17 PM (GMT -6)   
Jack,

Was reading this entire thread, and I fully agree's with Ralf's accessment. If your PSA decides to creep up on you at all, you will be the first to know with regular monitoring. Good luck.

David in SC
Age: 58, 56 dx, PSA: 7/07 5.8, 10/08 16.3
3rd Biopsy: 9/08 7 of 7 Positive, 40-90%, Gleason 4+3
open RP: 11/08, on catheters for 101 days
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incont & ED: None
Post Surgery PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, 8/6 .06, 2/11 1.24, 4/11 3.81
Latest: 6 Corr Surgeries to Bladder Neck, SP Catheter since 10/1/9, SRT 39 Sess/72 gy ended 11/09, 21 Catheters, Ileal Conduit Surgery 9/10

ralfinaz
Veteran Member


Date Joined Jan 2011
Total Posts : 735
   Posted 5/2/2011 1:26 PM (GMT -6)   
Jack,
There are no stupid decisions in this matter. No one knows with certainty what is the proper length of an on cycle with HT. Some say a longer cycle will benefit in killing more androgen dependent cancer cells. This potentially can also create more SEs and cause other health issues. This is why it is important to monitor PSA and some other markers to be able to resume therapy if necessary. Some expert oncologists claim that 9 months is the minimum timing so you are at least going to be there.

RalphV
Phoenix, Arizona
Surviving prostate cancer since 1992. RP; Orchiectomy;
GS (4 + 2); bilateral seminal vesicle invasion; tumor attached to rectal wall. Last PSA September, 2010: <0.1 ng/ml
Laughter is the best medicine!
www.pcainaz.org/phpBB304
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