Mel, I've been on Lupron since november, and I have not experienced any Significant change of personality. (according to my wife). She also commented that we get along better.
However I have not experienced any tendency to cry. I have had episodes of depression, however I'm not sure that has anything to do with the Lupron.
The most significant side effect has been the hot flashes. The hot flashes have been noticeably worse at bedtime.
I have also noticed that I have less stamina when working out. Since I have just finished building our retirement home, I have been doing a lot of landscape projects such as 4' high retaining walls which has involved a lot of manual labor. Since I have started these projects, I have noticed that I have to sit down and rest more often.
But, For the most part, I'm handling the Lupron okay.......for now. I hope it doesn't get any worse.
Age 57 at Dx
5/09 PSA 2.26
6/2010 PSA 3.07 FPSA 18% DRE +
Biopsy, 7 of 18+, >60%, 4+5=9
7/21/2010 - RRP
Nodes neg, Ves neg
tumor contained, still 4+5=9
9/3, 2010 PSA - 0.04
9/3/2010, I'm 99% continent
10/14/10, PSA still 0.04, and lupron #1, now 99.9% continent
Total ED, 3 caverject failed
10/20/10 OD'd .5cc trimix, after 3hrs, neo synephrine shot
tried .15 & .17 cc neg, next .2