Transdermal scrotal estrogens patches (TSEP) in the treatment of advanced prostate cancer.

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ralfinaz
Veteran Member


Date Joined Jan 2011
Total Posts : 735
   Posted 5/8/2011 2:07 PM (GMT -6)   
Transdermal scrotal estrogens patches (TSEP) in
the treatment of advanced prostate cancer.

Drs. Premoli, F*; Re, Irma.; Asenjo, G.; Maximino, G.; Micheletti, L.

To read the article in pdf format visit:

www.pcainaz.com/Pages/ETE_eng.pdf

RalphV
Phoenix, Arizona
Surviving prostate cancer since 1992. RP; Orchiectomy;
GS (4 + 2); bilateral seminal vesicle invasion; tumor attached to rectal wall. Last PSA September, 2010: <0.1 ng/ml
Laughter is the best medicine!
www.pcainaz.org/phpBB304

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 5/8/2011 2:56 PM (GMT -6)   
I have been waiting to see you post this type of info. Gee only Lupron is our salvation??
Now remember these findings published are in 'advanced PCa' scenarios....highly likely to have way better results with much lesser advanced scenario of PCa, kind of like when Dr. Fred Lee started his useage of emcyt another form of estrogenic therapies., into year 29-30 since diagnosis with found uncureable scenario.
 
Ralph tell the people herein how enthusiastic the Americans were to publish his findings on estradiol patches on his findings????  I am thus a 'cluer'  (lol).  These estrogenic drugs can sometimes be very effective on hrpca and work on patients whom already failed on LHRH or casodex...if you need the Journal article instead of my words, just let me know.
 
Ralph's website  www.pcainaz.org    (Dr. Premoli is envolved their too)
 
Brand names of some patches:  Vivelle or Climara  (as low as $150 from Canada for 40 count .025/ 24hr. version) www.northdrugstore.com 
You can buy estradiol gel too I have heard.
 
 

Post Edited (zufus) : 5/8/2011 5:13:12 PM (GMT-6)


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 5/8/2011 2:58 PM (GMT -6)   
No estrogen's can be beneficial. Folks need to know about them. They don't work in every case but they can certainly be an alternative option...

Folks should be asking about them with their oncologists when they prescribe the LHRH option.

Tony
Advanced Prostate Cancer at age 44 (I am 48 now)
pT3b,N0,Mx (original PSA was 19.8) EPE, PM, SVI. Gleason 4+3=7

Treatments:
Da Vinci Surgery ~ 2/16/2007
Adjuvant Radiation Therapy ~ IMRT Completed 8/07
Adjuvant Hormone Therapy ~ 28 months on Casodex and Lupron.
Undetectable PSA.

Blog: www.caringbridge.org/visit/tonycrispino

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 5/11/2011 7:12 PM (GMT -6)   
A friend of mine in year 11 with PCa and failing on Lupron, just started the patch thing a little over a month ago, I think using 1-2 patches and his psa actually went up a little (weird), he got walk in psa testings done for $15 each time you want one, anyway I saw him at my PC seminar type meeting and he now went to 4 patches and psa is atleast stabilized and not increased.

I gave him a copy of this, he never even heard of Dr. Premoli....so luckily I had it with me and now he can read up on those studies, which in his case is exactly what he wants to look at. He also knows plenty on PCa, has PCRI videos and alot of knowledge...surprized Dr. Premoli never hit his radar. So your timing for this was good, he needs to see that and he helps others, whom may need to look this kind of thing over. Plus I was able to pay if forward....LOL....Thanks.  I will send him to your website too.

Post Edited (zufus) : 5/11/2011 6:19:52 PM (GMT-6)


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 5/11/2011 7:16 PM (GMT -6)   
ralph,

excellent link and article, will save this one. interesting alternative to the usual Lupron spill.

i will add this to the list i am making questions for when i meet my new medical oncologist later this month.

david in sc
Age: 58, 56 dx, PSA: 7/07 5.8, 10/08 16.3
3rd Biopsy: 9/08 7 of 7 Positive, 40-90%, Gleason 4+3
open RP: 11/08, on catheters for 101 days
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incont & ED: None
Post Surgery PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, 8/6 .06, 2/11 1.24, 4/11 3.81
Latest: 6 Corr Surgeries to Bladder Neck, SP Catheter since 10/1/9, SRT 39 Sess/72 gy ended 11/09, 21 Catheters, Ileal Conduit Surgery 9/10

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 5/11/2011 7:24 PM (GMT -6)   
This would be perfect for you Purg....possible breast enlargement over time using this either combat it with electron breast minor radiation protocol or take femara drug or similar drug to counter that or accept some breast enlargement. Otherwise little to no side effects, works similarly to DES but by passes going through your liver (a plus) and less risks of any clots or dvt's. You do not need blood thinners with this either. Dr. Premoli I believe had no patients get either of those events. Works on even Hrpca...can outperform Lupron and casodex, can be used when those fail and found to work in patients.

Easy to do, lower costs and like about no side effects, also builds bone density and maintains memory (unlike Lupron).  Oh they don't have to be scrotally used, can be in other areas too.
 
So you know the pluses and minuses...some docs won't use them at all...no money in it and may wish to control what you do get to use for various reasons.  Good hunting.

Post Edited (zufus) : 5/11/2011 6:31:49 PM (GMT-6)


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 5/11/2011 8:12 PM (GMT -6)   
Yeah, zufus, it is a possibilty I will bring up when I meet my new oncologist. I am screwed in once sense, I will never consent to any more radiation, even for the breast thing, or if I start developing bone mets. Been burned twice on radiation, not going to ever do that again.
Age: 58, 56 dx, PSA: 7/07 5.8, 10/08 16.3
3rd Biopsy: 9/08 7 of 7 Positive, 40-90%, Gleason 4+3
open RP: 11/08, on catheters for 101 days
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incont & ED: None
Post Surgery PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, 8/6 .06, 2/11 1.24, 4/11 3.81
Latest: 6 Corr Surgeries to Bladder Neck, SP Catheter since 10/1/9, SRT 39 Sess/72 gy ended 11/09, 21 Catheters, Ileal Conduit Surgery 9/10
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