Can PSA after a biopsy indicate the aggressiveness of cancer?

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Gleason 6
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Date Joined Mar 2011
Total Posts : 876
   Posted 5/13/2011 1:22 PM (GMT -6)   
While waiting after a biopsy to decide which treatment to pursue, would a PSA test (after 3 months) give me any indication if the cancer is turning more aggressive (if it was climbing quickly) or just staying level (if the PSA was not climbing) and therefore give me an indication of how soon I needed to make a decision. Or is it the Gleason score that indicates the aggressiveness of the cancer? Or if the PSA is rapidly rising, can a Gleason 6 turn into a Gleason 7 or 8.
Age 61 Active. No other problems (except small hernia)
PSA 4.3 9/10
PSA 5.5 2/11
PSA 7.1 3/11
Template Biopsy 6 pos out of 40 3/25/11 GS 6 (3+3)
CT bone scan neg
6/18 areas positive - 2 in left base, 4 left apex. 6/40 cores pos. 33cc.
Stage T1C
Met with Dr. Wehle @ Mayo 5/4/11
Appointment scheduled with RO Dr. Buskirk at Mayo 5/17/11

Steve n Dallas
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Date Joined Mar 2008
Total Posts : 4829
   Posted 5/13/2011 1:33 PM (GMT -6)   

It probably took 20 years to get where you are now. Odds are good you won't turn into an 8 or higher anytime soon.

If your PSA jumps to 200+ then you can worry smhair


Gleason 6
Veteran Member


Date Joined Mar 2011
Total Posts : 876
   Posted 5/13/2011 1:49 PM (GMT -6)   
I just think about it because it was rising so rapidly before my biopsy
Age 61 Active. No other problems (except small hernia)
PSA 4.3 9/10
PSA 5.5 2/11
PSA 7.1 3/11
Template Biopsy 6 pos out of 40 3/25/11 GS 6 (3+3)
CT bone scan neg
6/18 areas positive - 2 in left base, 4 left apex. 6/40 cores pos. 33cc.
Stage T1C
Met with Dr. Wehle @ Mayo 5/4/11
Appointment scheduled with RO Dr. Buskirk at Mayo 5/17/11

John T
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Date Joined Nov 2008
Total Posts : 4229
   Posted 5/13/2011 4:51 PM (GMT -6)   
Subsequent psas can definately indicate the agressiveness of the cancer. A psa doubling time of less tha 3 years would indicate a non agressive cancer. The faster the doubling time the faster the tumor is growing. It is very unlikely that a G6 will turn into a G8 in a year or two.
JT
66 years old, rising psa for 10 years from 4 to 40; 12 biopsies and MRIS all negative. Oct 2009 DXed with G6 <5%. Color Doppler biopsy found 2.5 cm G4+3. Combidex clear. Seeds and IMRT, 4 weeks of urinary frequency and urgency; no side affects since then. 2 years of psa's all at 0.1.
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