Tom, I had the Iodine implants and expected my PSA to be cut in half (or better) at 6 months. After that it's a gradual decline with the median time to nadir at around 4 years. For Palladium, I recall (but can't find the reference now) that the median time to cutting the PSA in half is around 90 days. So...if you are at 2.4 or better, you should rejoice as being on the right track. However, even if you are above that don't fret too much since 90 days is the median and you might be in the half that takes longer than that. Actually, my doc had me wait 6 months before my first post-brachy PSA to "give it time"...
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Age 62 (64 now), G 3 + 4 = 7, T1C, PSA 4.2, 2/16 cancerous, 27cc. Brachytherapy 12/9/08. 73 Iodine-125 seeds. Procedure went great, catheter out before I went home, only minor discomfort. Everything continues to function normally as of 12/8/10. PSA: 6 mo 1.4, 1 yr. 1.0, 2 yr. .8. My docs are "delighted"! My journey: