One perspective on Adjuvant Therapies

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Tony Crispino
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Date Joined Dec 2006
Total Posts : 8128
   Posted 5/17/2011 3:17 PM (GMT -6)   
And that perspective would be my own.

My blog has been updated with my adjuvant therapy story which began four years ago tomorrow. many continue to ask me about it so I decided to make it a blog post. Here is that post:

www.caringbridge.org/visit/tonycrispino

I believe in this protocol at least for the stage III guys. Also the stage 3b guys have even more ammunition to consider this protocol with recent studies showing excellent survival benefits. Back when I made this decision it wasn't well documented but to me it was logical to add therapy when I knew the odds were against me. It also made sense to kick this thing while it was down. I do understand that it will take a while to prove anything. And in my one case I might not ever prove anything. But I think it was worth it. I hated the hormonal therapy the most and I still fear the possible repercussions of the addition radiation therapy. But I am satisfied with the attack on prostate cancer and the results I have had thus far...


Tony
Advanced Prostate Cancer at age 44 (I am 48 now)
pT3b,N0,Mx (original PSA was 19.8) EPE, PM, SVI. Gleason 4+3=7

Treatments:
Da Vinci Surgery ~ 2/16/2007
Adjuvant Radiation Therapy ~ IMRT Completed 8/07
Adjuvant Hormone Therapy ~ 28 months on Casodex and Lupron.
Undetectable PSA.

Blog: www.caringbridge.org/visit/tonycrispino

Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 5/17/2011 3:38 PM (GMT -6)   
OS,
Lupron works differently than Casodex. One stops production of testosterone and the other prevents it from being absorbed in the body. Not all cancers will respond the same to either. Still I like your results. May we both keep up the good reports...

Tony

142
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Date Joined Jan 2010
Total Posts : 6949
   Posted 5/17/2011 4:00 PM (GMT -6)   
OS,
 
OK, maybe I was confused too - I read:
 
Casodex over Zoladex, a Lupron like drug
 
to mean that Zoladex and Lupron were basically the same. So I also read a comparison to things "Lupron-like".

Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25380
   Posted 5/17/2011 4:05 PM (GMT -6)   
Tony,

I think your methodlogy could be a good model for many Stage III guys.
Age: 58, 56 dx, PSA: 7/07 5.8, 10/08 16.3
3rd Biopsy: 9/08 7 of 7 Positive, 40-90%, Gleason 4+3
open RP: 11/08, on catheters for 101 days
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incont & ED: None
Post Surgery PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, 8/6 .06, 2/11 1.24, 4/11 3.81
Latest: 6 Corr Surgeries to Bladder Neck, SP Catheter since 10/1/9, SRT 39 Sess/72 gy ended 11/09, 21 Catheters, Ileal Conduit Surgery 9/10

John T
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Date Joined Nov 2008
Total Posts : 4229
   Posted 5/17/2011 5:38 PM (GMT -6)   
Tony,
The PCRI has for years recommended adjuvant HT or combination treatment for all high risk cases not just stage 3 guys. This is a much more aggressive recommendation than most doctors would make, but I think it has merit considering the high reoccurrance rate of high risk patients. There is still a lot of disagreement as to how long to stay on HT. Killing small clusters of cancer cells that may have escaped before they have time to turn into tumors makes sense.
JT
66 years old, rising psa for 10 years from 4 to 40; 12 biopsies and MRIS all negative. Oct 2009 DXed with G6 <5%. Color Doppler biopsy found 2.5 cm G4+3. Combidex clear. Seeds and IMRT, 4 weeks of urinary frequency and urgency; no side affects since then. 2 years of psa's all at 0.1.

Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 5/17/2011 5:55 PM (GMT -6)   
John the use of adjuvant HT actually dates back to it's founder Charles Huggins who won the Nobel for his work.

But how to use it in conjunction with my protocol, stage, Gleason, etc ~ not well documented. Before PCRI was also Bob Leibowitz who has long since advocated HT as an adjuvant or primary therapy. But like PCRI there was no FDA approved study on it.

Tony
Advanced Prostate Cancer at age 44 (I am 48 now)
pT3b,N0,Mx (original PSA was 19.8) EPE, PM, SVI. Gleason 4+3=7

Treatments:
Da Vinci Surgery ~ 2/16/2007
Adjuvant Radiation Therapy ~ IMRT Completed 8/07
Adjuvant Hormone Therapy ~ 28 months on Casodex and Lupron.
Undetectable PSA.

Blog: www.caringbridge.org/visit/tonycrispino

compiler
Veteran Member


Date Joined Nov 2009
Total Posts : 7205
   Posted 5/17/2011 6:07 PM (GMT -6)   
Tony:
 
I just send you an email
 
Mel
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