Others can add what they found or know on this, I wish to see is this more of a breakthrough drug now or is it more of a re-engineering of Ketoconazole with a new patent and huge price tag...thus a method to cashin on PCa patients?
Some of the info I got from their website: (blue is my words of course)
What are the ingredients of ZYTIGA?
Active ingredient: abiraterone acetate
Inactive ingredients: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, povidone, sodium lauryl sulfate, magnesium stearate and colloidal silicon dioxide. (does this look like it is worth $5000/mo. for 1000mg of pills used at 4 per day of 250 mg)???
Symptoms of using such:
urinate more often than normal
need to get up at night to urinate
cold like sympto
joint swelling or pain
urinary tract infection
What are the possible side effects of ZYTIGA?
ZYTIGA may cause serious side effects including:
• High blood pressure (hypertension), low blood potassium levels (hypokalemia) and fluid retention (edema). Tell your healthcare provider if you get any of the following symptoms:
feel faint or lightheaded
pain in your legs
swelling in your legs or feet
• Adrenal problems may happen if you stop taking prednisone, get an infection, or are under stress.
• Liver problems. Your healthcare provider will do blood tests to check your liver before treatment with ZYTIGA and during treatment with ZYTIGA.
Ok so we know also this is used with prednisone, just like Ketoconazole and back when in trials they barred prior patients whom used Keto (there is a clue right there). They both target the enzyme Cyp17 (mentioned by Dr. Sawyers inventor of MDV-3100 on a interview blog on internet). They have very similar overlapp on side effects and perhaps on other drug interactions. Keto has strick useage adherences as to 8 hour time frame for taking it, acidic stomach prior maybe with juices (they both say that is how to take it), they both have some drug interaction variables to be aware of that could even be threatening (doc should know all your drugs taken prior). In trials this drug showed a 4 month survival advantage and that is always misleading, Provenge showed similar too but in some patients (all were high risk in trials) lived 4 years thereafter. So it could do way better than a 4 months thing...so you see I am being fair minded on that.
Other things with useage possible: high BP, edema, low potassium levels which are now mentioned. The company is Centocor Ortho Biotech (part of (J&Johnson-?) and mfg. company is Patheon Inc.-toronto, canada.
I think the website was: www.zytiga.com for informations on it.
I don't know if this is good news or not at this point, I am highly suspecious of this being way overpriced and more companies are looking at such things in making profits. They now offer an assistance program for people whom cannot afford it (that should be most people on the planet).
Seems like spending $5000 a month on PCa protocols is not big deal now...I hope this is not the 'new' trend these days. My opinion of course...I do like more choices and anything that helps. This needs price competiton, look at the ingredients listed....see $5000 a month in that for pills??? Just my observation and .02 cents and definitely pro-patient.