Does your husband take one 50mg dose of Imipramine daily and did the doctor specify a specific time of day to take it? I started with a 5mg dose of Imipramine taken at bedtime, then 10mg...25mg...finally 50mg. I wasn't sure if the Impramine was helping or I was getting better, continence-wise, because of the healing process, time, and Kegels. I voluntary stopped taking the Imipramine for two weeks and found that I was leaking much more (not as much as the first month post surgery but significantly more than when on Imipramine). The drug helps me, but I still leak too much for this to be the complete solution.