Prostate Cancer Research - Good News and Bad News

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Drums
Regular Member


Date Joined Mar 2010
Total Posts : 134
   Posted 6/2/2011 8:56 AM (GMT -6)   
The good news is that a lot more money is projected for PC research and more attention will be given to the disease. The bad news is that a cure is not in the mix of projected research areas.
 

Analyst: Prostate Cancer Therapies Sales To Reach $5 Billion By 2015.

Bloomberg News (6/2, Waters) reports id Eric Schmidt, a Cowen & Co. analyst, said that "the market for prostate cancer therapies" will climb "to $5 billion by 2015 from less than $1 billion now, Schmidt said." Charles Ryan, a medical oncologist and prostate cancer researcher at the University of California, San Francisco, said that the "while these drugs don't cure the disease, the therapies give doctors options to help patients live longer." Bloomberg News notes that Johnson & Johnson, Medivation and Takeda Pharmaceutical "will report study results this weekend at the American Society of Clinical Oncology meeting in Chicago."


52 at Dx (3/12/10), father died of PCa
PSA: 10/16/09 - 2.8; 1/11/10 - 3.8; since RALP - <0.1
RALP 5/19/10, Dr. Lee, U. Penn Presby
Gleason 6, gland involvement < 2%; tumor in peripheral zone both sides; no capsular, extracapsular extension, lymph node, or seminal vesical involvement; no positive margins
Incontinence: no pads except at karate
ED: pump. Levitra 10mg every other night

Fairwind
Veteran Member


Date Joined Jul 2010
Total Posts : 3631
   Posted 6/2/2011 10:06 AM (GMT -6)   
I read somewhere that Medicare alone spends over one billion dollars a year on just ADT drugs specific to PC treatment...It was one of the fastest growing expenditures..
Age 68.
PSA age 55: 3.5, DRE normal.
age 58: 4.5
61: 5.2
64: 7.5, DRE "Abnormal"
65: 8.5, " normal", biopsy, 12 core, negative...
66 9.0 "normal", 2ed biopsy, negative, BPH, Proscar
67 4.5 DRE "normal"
68 7.0 3rd biopsy positive, 4 out of 12, G-6,7, 9
RALP Sept 3 2010, pos margin, one pos vesicle nodes neg. Post Op PSA 0.9 SRT, HT. 2-15-'11 PSA 0.0

mole-mar-gaddafy
New Member


Date Joined May 2011
Total Posts : 8
   Posted 6/2/2011 10:40 AM (GMT -6)   
Don't you feel the love and concern for patients(-: Johnson & Johnson no doubt with this forecast...they are the ones behind the scenes in Zytiga/Abiraterone (it is made in Canada, probably cheaper for them). I can see the logic from J&J, they just got FDA approval for 'Abby' and these little pills will cost us $5,000 a month for (pills???). I did some investigation, as I know these firms are only trying to service us (I mean serve us patients). Well 'Abby' targets the exact same enzyme that Ketoconazole does (namely CYP17)...and I kind of believe it is re-engineered Keto with a new patent, perhaps it is more potent, the price surely is more potent...Keto from Canada pharmas from as low as $130 for 90 pills vs. $5,000 for 120 of the 'Abby' (approx.).

The clues on this: in trials Abby patients whom did Keto prior were excluded (mentioned by DR. Myers to, in a video), they target the same enzyme, they both require you to use Prednisone and they have similar side effects to some degree. The big one is Dr. Swayers whom invented MDV3100, in a blog interview thing mentioned they both target the enzyme CYP17.

Now since many companies are seeing they can cash in on cancer patients more easily than ever, our new drugs are likely to be based upon what level of pain and extraction they can get away with. Examples of our rip offs: Provenge $93,000 and is not a cure, Revlimid pills around $150 each, Leukine injections patients cost would be around $5,000-7000 a month. So, based upon these findings....the mole-mar drug analogy theory is: most newer protocols for drugs and vaccines have set the bar at around $5,000 a month as acceptable and is fine for open season on us customers and bigger profits for the humanity lovers. Maybe for those without insurance they may throw a few bones out of this high priced items, to look wonderful to the public. (great....celebrate). rolleyes

I suspect MDV3100 and ANR-509 to get approved in 1-2 years, let us see what that price tag is in comparison and just for kicks!!! I think they are smart enough to make it lower and grab market share, but just guessing. I have to fly back to Lybia today (LOL).
Funny how the low priced stuff is not used by hardly any doctors, must be a coincidence.
Casodex+proscar found to be about equal to Lupron+casodex in controlling non refractive PCa....how many are getting anything other than Lupron????  Beuhler....Beuhler??

Post Edited (mole-mar-gaddafy) : 6/2/2011 10:46:11 AM (GMT-6)


RobertC
Veteran Member


Date Joined May 2011
Total Posts : 1300
   Posted 6/2/2011 12:23 PM (GMT -6)   
The ACSO cancer meeting is starting this week with new reports.
An article I saw today about a way to try to control costs of new meds:
Reuters
Ziopharm seeks lower cancer drug prices
Wed, Jun 1 2011

By Bill Berkrot

NEW YORK (Reuters) - Ziopharm Oncology Inc's Chief Executive Jonathan Lewis has an idea that could shake up the biotechnology business -- produce less expensive new cancer drugs.
"Part of our philosophy from the very get-go has been low cost," Lewis told Reuters in an interview. "Keep the cost of goods down, cost of development down, cost of the drugs down."

Lewis said his company's most advanced drug in development, palifosfamide for sarcoma and lung cancer, can be a $1 billion a year seller even if reasonably priced.
But the linchpin to Ziopharm producing less expensive biotech drugs is an experimental new technology known as synthetic biology developed by its partner Intrexon Corp.

Lewis sees synthetic biology transforming biotech drug manufacture the way Henry Ford's assembly line changed automobile production.
"This has the potential to revolutionize how we make drugs, to get cost down, down, down," Lewis said on Wednesday.
"The world is changing; the U.S. is changing. Very expensive drugs are going to struggle," he said.

With the Intrexon technology, DNA is assembled from stored parts using robotics and programed to stimulate production of specific cancer killing proteins inside a tumor. The protein is activated or turned off by a pill to control toxicity.
The current expensive and complicated biotech production model involves protein based medicines manufactured in huge vats in carefully controlled environments.

"We don't use those great vats to create the protein, but use the person to create the protein," Lewis explained, adding that lower sales price does not necessarily mean lower profit.

"People will still make money because it costs less to do it," Lewis said.
The process has been tested in a 9-patient early stage advanced melanoma study to be presented at the American Society of Clinical Oncology meeting that starts on Friday.
It will take far larger trials to determine if synthetic biology represents the revolution Lewis envisions.

Ziopharm expects to file five investigational new drug applications (INDs) seeking approval to begin human trials using synthetic biology next year and eight more in 2013.
"We think we can do this relatively quickly, within the next few years," Lewis said.

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 6/3/2011 4:30 AM (GMT -6)   
Robert- you seem to be a rather inciteful person, my guess is you have some kind of background perhaps related to medical or researching???? What is your incitefulness coming from, if you don't mind me asking? The Ziopharm seems interesting and we would have to see how that pans out. Meanwhile of course we have plenty of cynicizm on what is going on, the examples speak for themselves.

RobertC
Veteran Member


Date Joined May 2011
Total Posts : 1300
   Posted 6/3/2011 7:25 AM (GMT -6)   
Hey and thanks Zufus.
I'm retired from a computer specialist job. I have a lot of time on my hands and like to read about trials and prevention.
I see you know a lot about the prostate cancer area and meds. Best....Robert
Gleason (3+4) 7, PSA 5 in November 2011
cryoablation in January 2011.
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