Statin drugs and PCa

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kbota
Regular Member


Date Joined Aug 2010
Total Posts : 486
   Posted 6/13/2011 5:58 AM (GMT -6)   
www.thirdage.com/news/cholesterol-drugs-may-lower-prostate-cancer-risk_06-12-2011

Most of us have heard about statin drug use for PCa. This article provides additional information on the subject.

K

daveshan
Regular Member


Date Joined Jan 2010
Total Posts : 363
   Posted 6/13/2011 6:41 AM (GMT -6)   
Thanks K,
My uro had my GP put me on statins early on as she was up on the latest research. I had marginally elevated cholesterol and a skewed ratio so it was justifiable medically. Don't know if it's helping but still <0.0x
Dave in Durango CO

07-06 PSA 2.5
01-08 PSA 5.5 (Dr never told me)
09-09 PSA 6.5 (age 55)
12-09 Biopsy, initial Gleason 9 (4+5) later reduced to 8 with tertiary 5
03-01-10 Age 55 RRP in Durango CO by Dr Sejal Quale and Dr Shandra Wilson
03-16-10 Path' G-8 (4+4+5) Bilateral involving 21% of left lobe, 3% of right lobe, SVI, Focal positive margin, pT3b NO MX

All PSA as of 5-03-11 <0.04

clocknut
Veteran Member


Date Joined Sep 2010
Total Posts : 2667
   Posted 6/13/2011 6:50 AM (GMT -6)   
Is a 3 percent difference between the two groups really all that significant?  55 percent of those taking statin drugs were found to have cancer.  58 percent of those not taking statins were found to have cancer.
 
Count me in the 55 percent, since I've been taking Lipitor for years.  In fact, I was a participant in the studies of Lipitor before it even went on the market.  It doesn't seem to have done much in my case to prevent prostate cancer, or even to protect me from the more aggressive Gleason 4 strain. 
 
Of course, one might argue that my situation would have been even worse had I not been taking the statin drug, but that's purely speculative.  Thanks for posting, Kbota.  Maybe the fact that my familial strain of high cholesterol is over 300, even with strict diet control (but reduced to less than 200 with statin drugs), puts me in a category too high to benefit from statin usage.
Age 65
Dx in June 2010.
PSA gradually rising for 3 years to 6.2
Biopsy confirmed cancer in 6 of 12 cores, all on left side
Gleason 7 (3 + 4)
Bone scan, CT scan, rib x-rays negative.
DaVinci 8/20/10
Negative margins; negative seminal vesicles
5 brothers, ages 52-67 ; I'm the only one with PCa
Continence OK after 7 weeks. ED continues.
PSA 1/3/10: 0.01

kbota
Regular Member


Date Joined Aug 2010
Total Posts : 486
   Posted 6/13/2011 6:52 AM (GMT -6)   
Clock, I noticed that 3% also, and was disappointed that it was so small.

And I, like you, have been taking a statin drug for years for a very mildly elevated cholesterol (205). After taking crestor, my total cholesterol dropped to 135.

But I'll take any help at all with PCa.

K

Post Edited (kbota) : 6/13/2011 6:58:33 AM (GMT-6)


medved
Veteran Member


Date Joined Nov 2009
Total Posts : 1096
   Posted 6/13/2011 8:30 AM (GMT -6)   
The thing I have always found difficult about the statin studies is figuring out whether any reduced incidence of prostate cancer (or high grade prostate cancer) is attributable to the statin, or to low cholesterol (or high HDL or low LDL)? In other words, is it something in the statin itself that helps, or just having good cholesterol levels? I have asked a couple of experts this question, and the basic answer is "nobody knows."

compiler
Veteran Member


Date Joined Nov 2009
Total Posts : 7203
   Posted 6/13/2011 9:11 AM (GMT -6)   
I take 10 mg. Lipitir for mildly elevated cholest (209).
 
Is this dosage enough from the anti-PC viewpoint?
 
Mel

tarhoosier
Regular Member


Date Joined Mar 2010
Total Posts : 486
   Posted 6/13/2011 9:26 AM (GMT -6)   
I believe the difference is due to the cholesterol reduction, not the statin itself. Cholesterol is a precursor molecule to testosterone (and estrogen). The molecular similarities are striking between the three. It is presumed that in advanced PCa that cholesterol is converted to androgens and this may occur earlier in the disease stage as well. There have been studies in men in late stage disease where those on statins survived longer than those not. Other lab studies using beakers and test tubes show cholesterol conversion to testosterone is easily done by common metabolic properties.
Statins may serve a small role in the fight, though the cancer trumps all.

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 6/13/2011 10:21 AM (GMT -6)   
Mel- ask your doc if it is allowed legally to take Simvastin instead of Lippy drug which is high priced. My onco had me try Simvastatin (derivative of Salmon) and it worked well and fast and I dropped it now because it worked that well, my number below 200 for months now. He doesn't love seeing wasted money in the system I guess (lol). All the new drugs seem to be much higher than the previous or older drugs, what an observation (lol). Never question anything of course and ask for validated parking (lol).

clocknut
Veteran Member


Date Joined Sep 2010
Total Posts : 2667
   Posted 6/13/2011 10:56 AM (GMT -6)   
Zufus, why would there be any question of "legality" in switching from one statin drug to another? People do it all the time. My doc has suggested that I switch from expensive Lipitor to one of the much less expensive generic statin drugs, but my wife and I have resisted because we've tolerated Lipitor so well and have had excellent results. I just don't understand what you mean when you say "ask your doc if it is allowed legally." I'm pretty confident that anyone on Lipitor can call their doc and say, "Hey, I'd like to switch from Lipitor to Zocor or Mevacor" and their doc will say, "OK, I'll write you a script for that."
Age 65
Dx in June 2010.
PSA gradually rising for 3 years to 6.2
Biopsy confirmed cancer in 6 of 12 cores, all on left side
Gleason 7 (3 + 4)
Bone scan, CT scan, rib x-rays negative.
DaVinci 8/20/10
Negative margins; negative seminal vesicles
5 brothers, ages 52-67 ; I'm the only one with PCa
Continence OK after 7 weeks. ED continues.
PSA 1/3/10: 0.01

compiler
Veteran Member


Date Joined Nov 2009
Total Posts : 7203
   Posted 6/13/2011 11:01 AM (GMT -6)   
Actually, my doc started me on zocor.
 
I tried it at least 4 times but had to keep quitting due to muscle and/or intestinal SE.
 
Oddly enough, I've had no problems with lipitor
 
Mel

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 6/13/2011 5:37 PM (GMT -6)   
clocknut- it was sarcasm used on that for special effects (LOL)....sorry it got mis-con-screwed.

clocknut
Veteran Member


Date Joined Sep 2010
Total Posts : 2667
   Posted 6/13/2011 5:43 PM (GMT -6)   
OK, Zufus.  Oh, and if you see any black helicopters circling your residence....I didn't send them after your generic statin drugs.  Just want you to know that :)
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