My post surg pathology on 3/25/09 was dismal. Gleason 9, sem vesicles involved and 2 of 9 nodes positive, PSA .6. Finished SRT 3/10. PSA continued to slowly rise. On 4/3/11 I was at 2.28 and the rise was slowing even further. All of a sudden two months later my test results were 3.65.
I am astonished and shaken. Because of the very slow rise I have deferred on starting any ADT up until now. My doubling time was well over eighteen months and within eight weeks it has dipped to below six months. Is this possible? Should I abandon my wait and see plan and immediatedly jump into ADT or wait for another test? My oncologists are pretty much leaving it up to me. Has anyone else ever had such a dramatic acceleration in PSA?
Thanks for any input.
11/08/08 annual checkup (3 yrs late) PSA 8.04 from previously 2.7 in 11/05
1/23/09 biopsy 12 cores positive, 10 cores Gleason 7, 2 cores Gleason 8 70% tumor
2/06/09 cat +bone scans clean ..
3/26/09 RRP surgery Post op path .. upgraded to Gleason 9 (5+4), seminal vesicles involved, several positive margins, 2 of 9 lymph nodes positive.